Hpse000478.1
Basic Information
- Gene Symbol
- -
- Assembly
- GCA_947369225.1
- Location
- OX376336.1:5337558-5356484[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 19 0.0048 0.31 12.0 2.8 1 23 52 75 52 75 0.96 2 19 0.0041 0.27 12.2 1.7 2 23 109 131 109 131 0.96 3 19 0.00043 0.028 15.3 1.3 1 23 137 159 137 159 0.97 4 19 2.9e-06 0.00019 22.1 1.9 1 23 165 187 165 187 0.98 5 19 6.9e-05 0.0044 17.8 3.7 1 23 193 215 193 216 0.95 6 19 0.066 4.2 8.4 3.2 1 23 270 293 270 293 0.93 7 19 4.7 3e+02 2.6 0.1 2 23 303 324 302 324 0.91 8 19 0.016 1 10.3 0.9 2 23 330 352 330 352 0.95 9 19 1.5e-05 0.00099 19.8 3.0 1 23 358 380 358 380 0.97 10 19 1.3 81 4.4 1.0 1 11 386 396 386 400 0.93 11 19 0.011 0.69 10.9 4.2 1 23 417 440 417 440 0.97 12 19 0.0037 0.24 12.3 1.5 2 23 476 498 476 498 0.95 13 19 9.3e-05 0.006 17.4 1.6 1 23 504 526 504 526 0.96 14 19 0.068 4.4 8.4 0.7 1 11 532 542 532 545 0.94 15 19 0.098 6.3 7.9 6.7 1 23 562 585 562 585 0.96 16 19 0.021 1.3 10.0 1.0 2 23 621 643 621 643 0.95 17 19 0.057 3.7 8.6 2.0 1 23 649 671 649 671 0.96 18 19 0.00027 0.018 15.9 3.8 1 23 677 699 677 699 0.98 19 19 0.028 1.8 9.5 5.5 1 23 705 728 705 728 0.95
Sequence Information
- Coding Sequence
- ATGTCGCCTTTGAGCTCCGTGGGCAACCGATTGAAAAGTAGCCGCTCACTGTACCCCGCTCAATGCCTCACCACGTTCAGTCTGGGGACGAGGGTACTAGGTAAAGAACTGAACCAGCATTATACAGTCAAAGAAGAGGACGGGAAGCGCAACTTCATCTGTAACCTATGCGAACGCATTTTCAAGAAACGCATGTATTTCAAACAGCATTACAAGAATGTTCACCTGCAATTGAAGCTTGGTTCTTGTTACATTTGTGGGGTGAAGGTAGCGACGCATTTGAGGGCGGCGCATCTTGAAGCCTGCCATGGTATCCCCGCTCCTACTTGTGGAGTATGCAATAAGAAGTTTGCATTCCCAAACCAAGTACTACGCCATCACAAAAGCGAACACATGGGAGAAAGGAACTACGAATGCTTGACATGCAACATGAAGTTTCCCACGAAAGACAGACTCAAACGCCACGAAATCAAGCATTCTCCATTAGAAGCATTCGTTTGCAACTACTGCGGCAAATCTTTCAAGTGGAAGAAGAATTTGTTCACTCACATTAAGATACATTTGAACGATAGGAGGTACGCTTGTACGCTTTGTGGCATGACGTTTGTGCACAGGACCAGTTTGAGGTACCATATGGCGAAGCATCACCCGAATTATGCGTCGACGTCGACGGAGGAGCCGCTGGAATACGTTGTGAGGCCTGATAGAGCCTACAGCGAGCCGCTGCCCAAGGATAAGCCTGTGTCGCGGATTGGAAAGTACCTCGACGAATTTACCGTCTTTGAAGCTGAAGGCGGGACGGAAAACTACCGTTGTAATACGTGCGCCAGAGAATTCAAGAAACGTGCGTTTTTCACACACCACTTCGCCATTGTCCACCTCAACATGCGACGTAATAAACTGATCTCCTGCTTCCTATGTGACGTAAAAGTACGCAGTTACGAACGAGCAGCGCACATGGAAACTGCTCACGGCTTCCCCGCACCAAAATGCGATGCCTGTAACAAGAAATTCGCATTCCCATTCCAAGTCTTAAAGCATCAGAAGGAATATCACATGGGGGAAAAGAAATACGAATGCAAAGTTTGCCCCAAAAGATTCACTACGCAAGAATGTCTTAAACAACATGAAATTAAGCATTCTGATGAGAGGAAGTATATTTGCGAGTATTGCGTCAAGTCTTTTAAGTGGAAGAGAAAATACATCACCGAATTTACTACCTTTGAAGGCGAGGACGGGACTGAAAACTACCGTTGTAACACATGCGCCCGAGTATTCAAGAAACGTAATGGTTTCACGCAACACTTCAGATATTTCCACCTCAAAATACACGGTAAACTTAGATCCTGTCACCTGTGCGACGTAAAAGTACCCGGTTACGAACGAGCAGCTCACATGGAAAAGGCCCACGGCTTCCCCGCACCAACATGCGAAACTTGCAACAAAAAATTCGCGTTCCCATTCCAGGTTTCGAAGCATCAGAAGGAATATCATATGGGGGAAAAGATATACGCATGCAAAGTTTGCACCAAGAAGTTCGCGACCCATGACAGTCTTAAGCAGCATGGGATCATGCATACGGCGCAGAGGAAATATATTTGCGATTATTGCGACAAGTCTTTTAAGTGGAGGAGGAAGTACACCGAATATTCCACCATTAAAAACGAGGACGGGACGGAAAGCTACCGTTGTAACTTGTGCTCCCACGTATTCAAGAACCGGCCTTGTTTCGCGCAACACTTCAGATATTCCCACCTCAAGATACGACCAAAAGTGATATCCTGCCATCTATGTGACGTAAAAGTGCCCAATTACTTACGAGCAGCTCACATGGAGAAGGCCCACGGTCTCCCCGCACCACAATGTCAAGCTTGCAACAAAAAATTCGCATTCCCATTCCAGGTTTTGAAGCATCAGAAGGAATACCATATGGGGGAAAAGAAGTTCGAATGCAAAGTCTGTCATATGAAATTTATTAATATGGACAGAGTTAGGACGCATGAAATCAAGCATACGGGAGAGAGGAATCATAAATGCACGTTCTGCGACAAGTCTTTTAAATGGAGGACTAATTTGAGGGTGCATTTATTGATGCATAGGAATGAGAGACGCCATGTTTGTCTGCACTGTGGCGACTCGTTCGTTCAGCATAGCAGCTTGACTTATCATTTGACGAAGCGTCACCCGGAATCTGTTTAG
- Protein Sequence
- MSPLSSVGNRLKSSRSLYPAQCLTTFSLGTRVLGKELNQHYTVKEEDGKRNFICNLCERIFKKRMYFKQHYKNVHLQLKLGSCYICGVKVATHLRAAHLEACHGIPAPTCGVCNKKFAFPNQVLRHHKSEHMGERNYECLTCNMKFPTKDRLKRHEIKHSPLEAFVCNYCGKSFKWKKNLFTHIKIHLNDRRYACTLCGMTFVHRTSLRYHMAKHHPNYASTSTEEPLEYVVRPDRAYSEPLPKDKPVSRIGKYLDEFTVFEAEGGTENYRCNTCAREFKKRAFFTHHFAIVHLNMRRNKLISCFLCDVKVRSYERAAHMETAHGFPAPKCDACNKKFAFPFQVLKHQKEYHMGEKKYECKVCPKRFTTQECLKQHEIKHSDERKYICEYCVKSFKWKRKYITEFTTFEGEDGTENYRCNTCARVFKKRNGFTQHFRYFHLKIHGKLRSCHLCDVKVPGYERAAHMEKAHGFPAPTCETCNKKFAFPFQVSKHQKEYHMGEKIYACKVCTKKFATHDSLKQHGIMHTAQRKYICDYCDKSFKWRRKYTEYSTIKNEDGTESYRCNLCSHVFKNRPCFAQHFRYSHLKIRPKVISCHLCDVKVPNYLRAAHMEKAHGLPAPQCQACNKKFAFPFQVLKHQKEYHMGEKKFECKVCHMKFINMDRVRTHEIKHTGERNHKCTFCDKSFKWRTNLRVHLLMHRNERRHVCLHCGDSFVQHSSLTYHLTKRHPESV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -