Basic Information

Gene Symbol
RREB1
Assembly
GCA_035045065.1
Location
JAWNNK010000452.1:1533844-1540404[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.036 3 8.8 0.8 1 21 256 276 256 278 0.93
2 12 0.00034 0.028 15.2 0.2 1 23 288 310 288 310 0.98
3 12 8.1e-05 0.0068 17.1 7.3 1 23 316 338 316 338 0.98
4 12 0.096 8 7.4 1.7 2 20 570 588 570 590 0.93
5 12 0.0084 0.7 10.8 0.1 1 23 735 757 735 757 0.97
6 12 1.2e-05 0.001 19.7 0.7 1 23 767 789 767 789 0.99
7 12 0.00083 0.07 13.9 2.0 1 23 795 818 795 818 0.97
8 12 0.003 0.25 12.2 2.0 1 23 1097 1120 1097 1120 0.95
9 12 8.6e-05 0.0072 17.0 0.3 2 23 1475 1496 1474 1496 0.97
10 12 0.15 12 6.9 6.3 1 23 1502 1525 1502 1525 0.97
11 12 0.0084 0.71 10.7 0.5 3 23 1737 1757 1735 1757 0.96
12 12 0.0013 0.11 13.3 4.8 1 23 1763 1785 1763 1785 0.99

Sequence Information

Coding Sequence
ATGCTGgcaacacagcagcaacagcagccaacaacaacaggagcagcagcagcagcaacaacagcgtcAAGCACATTGGGACATGGCATCGACAGAGTGGAGATGGATCTGCGCCAGCGGCGGGATTCGAGCACCTCAGAGTCCTCGCTGGAGCACCTGGATCTGGGCCGCACACCAAAGaagctgagcagcagcagcggggcGCCGCAGCCGACGTCGACGCCGCACGAGGCagcgacggcaacggcgacgtcGCGCAAACGCAAGCtgcgccagcagcaacagccacagcaactgctccagcagccgcagcatcCGTTCTCCGACGaggatgagcagcagcagccacagcagccgccgcagctgGAGGCGACAGTGCAGCGACCACGTCACAAGCAGCGACGCAGCGGCAATGCGACGGCCGCTGCCAGCGCCAGCATCGTCGTCGACTACAGCGCCAGCGGCGACGCCAGCTCGCTGCGCAAGAAGTTCCGACTGAACCGCAGCAGCGCCAGCCTCAGCACCAACGGCGAACTGTCCGAGTCCGGCTTCGTCGACGGCAGCGCCCACAGCGGCTATctgctcagcagcagcagcaacaacagcaacaacagcaacgcaaCAGCGCAGTCGACGACatcggcgacagcgacagcggcagcgcagcagcaggcTTCGAGCAGCAGCTCCGGCGGCAGCTCACCCCACGGCCTGTGCATGTCCAGCGCCGAATCCGGCATCGGCGCCGGCGACGACCACATGAAATATCTCTGCCCCATCTGCGAGGTGGTCTCGGCCACGCCCCACGAGTTCACCAATCACATACGCTGCCACAACTACGCCAATGGCGACACCGAGAACTTCACCTGCCGCATCTGCTCCAAGGTGCTGTCCTCCGCCTCGTCGCTGGACAGGCACGTGCTGGTGCACACGGGCGAGCGGCCGTTCAACTGTCGCTACTGCCACCTGACCTTCACCACCAACGGGAACATGCATCGCCATATGCGCACCCACAAGCAGCACCAGGCGACGACCCAATCGGCGGGTgccatgcagcagcagcagtcgcagcagcagcagtcgcagcagcaacagcagcagcagcagcgacgtcagCAGCACGTTGCAACGGaagctgtggcagcaactgctggTGCGGGCGCACAGGCAGCTGGAGCGCGTGCCGAGAGCTATGAGAGCGATGCCAGCTGCTCGACGGATGTGTCCAGTGCGCAgagtcacagcagcagcagctcccaggcgaacagcaacaacagcaacaacaacaacaacaacagccacaaaacgaacaacaacaaccacagcaacaacaacaacaacaacaacgaggaggagctggaggtggagctcgagctggaggaggagcagctggagcGACGCGCAGGCGGCAAGCAGCGACGCCTGAAGACgaccatcaacaacaacatcatcaacgatgaggaggaggatcaggaggaggagcagcaggagcacaTGGACAACGATGATGCGGACAGCGTGGATGTGGCCCAAGTCATCACCAGCACGCCGGATGTGGCCACGTTGCTCGCCTCCGAAGGCACTTCCCCCTCCCATTCGCCGGGtccgccgctgctgctcagCTGTCCCGCCTGCAACGCGGCTGAATTCGAATCCTTGCCAGCTCTGTGCGCCCACCTGGACGCACTCCATGCGGACATCCCAGCCAAGTGTCGCGAGTGCGACGTCATCTTCGCCAGCCATCGCCAGCTGCAGGCGCACAGCTGCCGCGCAGCCAATGGATTGCCGCTGATGCCGCCGCTGGGCGCCAGCTCATCCCCGCTGCACaagcaggagctggaggatgaggacgaggagcAGGATGAGCATGAACTGGagcgggagcagcagcagcgtctggAGCAGGCACTGCCCAGCGAACGCGACGACTTCTTTCAGCAGCTCTACCTCAAGGGCAAATCCTCGCAAGCCCAGCTGCCGTCACCCATCAAGCACGAGCCGGCGGATCGCCAGGACCTGGCGGACATACAGTCCATCCTCAACAtgaccagctccagctgcaccTCCAGCTTTCTGCGCAACTTCGAGCAGTCCGTGAACACGCCCTGCTCCAGCCAGTACAGCGTCGATGGACGCGACTGCGAGGAGGAGGCCCAGGACGCCTTCACCAGCGAGTTCCGGCGCATGAAGCTGCGCGGCGAGTTCCCCTGCAAGCTCTGCACCGCCGTCTTTCCCAATCTGCGCGCCTTGAAGGGCCACAACCGGGTGCACCTGGCCGCCGTCGGACCCAGCGGTCCCTTCCGCTGCAACATGTGTCCCTACGCCGTCTGCGACAAGGCAGCGCTCGTGCGGCACATGCGCACCCACAACGGGGATCGGCCCTACGAGTGCGCCGTCTGCAACTACGCCTTCACCACGAAGGCCAACTGCGAGCGGCACCTGAGGAACCGCCACGGCAAGACCAGCCGGGACGAGGTGAAGCGCGCCATCGTCTACCATCCCGCCGAGGACGCCAGCTGCGAGGAcgccaacaccagcagcagcaacaagtccGGCTCCCGCCTCGGCGAGCACGACCTCTCGGAGCTCAGCTATCGCGCCCAgacgccaccaccgccgccagctgctccagcagcagaagctgccTCCCAGCTGAAGCACATGTTGCTGGCCGagcccgcagcagcagcagcagcagttgctgtcaAGCCCGAGCCGCCGCAGCCAGCGCTCAAGATTCAGGTGAAGAGCCTCGATCAGCTGGTGGACAAGCCTGTCGCACCGCCCACGCCAGCCATGGACCTCAGCATGGATGTGCTGGATCTCAGCAAGAAGCCAGCCGCGGCTGCAGTTGCTCAGGAGCTGCTGGAGCGcgagcgggagcgggagcacgagctgctgctccagcaccagcagcagcagcagcagcgggagcagcagcagcagcagcagcagcagatgttTGGCGCTGGAGACGCTGCCTCGCAGTACATGCAGCAGCTGTTCCGGAACCTGATGTTCCAGCAGTCGCCGGCGTTTCCCTTCTTCAGCTTCAtggcgccgccgccgccagcgGCTGCCGACGGCAAGCAGCAGGCCGCAGCGGCCGGAGCCACTGCCTcgcccacagcagcagctgcagccgcagcgGGTCTGCCCCTGCCGCTGCCGCTCTccggcgtgggcgtgggcgtgccCGTGCCGGCGGGTGGCCCCGTCAAGATGGTCATCAAGAACGGAGTCCTGATGccgaagcagaagcagcgtcGCTACCGCACGGAGCGTCCCTTTGCCTGCGAGCACTGCTCGGCGAGATTCACGCTGCGCTCCAACATGGAGCGCCACgtgaagcagcagcatccgcAGTTCTATGCCCAGCGCCAGCGCAGCGGGCACCACGTGATGCGCGGACGCGCTGCCTCCTCCaatgcggctgcggctgcggcggcggcggcggcagctgctgctgcggcagcggcCATGAACAATCtcagccagcagcaacatggcCATCATGGACACCATGCGCCCATCTCGGAGCAGGTGAAGTACGCGATCCTCGCGCAGCAGCTGAAGGCGCGCAAGGACACGGATCTGCTGCAGCAGGCGCTGGCCCATGGCTCCAGCAGCGTCGTGGCCAATCCTCTGCTGCACTTCAGCAGCTACAAGAATCCCAATGGGAATCCGAATGGCGCCACCAATGGTCATCGGGCGACGCCTCTGGCTGTGGACGATGATGAGCCGAAGCTGGTGATcgatgaggatgatgaggaCGAGTTCGAGGATGTGGACGAGGAGGatgagctggaggaggaggagcagcagtgGAAGCTCGAAATGGAgccggaggaggaggatgaggagccagaagagcaggaggagcagcaccagcagctgcaggaggGAGAGCAGCCAGCGGAGGAGCTTCAAGCGCACACACCACCCATGGAGGCGGCCAAGAAGGTGGCCGAGACCATCCTGGAGCAGGCCATCAAGGCGGGCAAGTCCAGCGAGAAGGAGGTGGAAGTGGCGCCCGAGCCGGCAGCTCCGGCGGCGCCCATGGCCACGCCTGGCGCAGCTCCCTCAGCCGCAGCACCGAATACGATGAAGACGATGATTGCCCAGGCGGAGTCGGTGGCCAAGTCCCTGAAGGAGGTGGCCAGCTCGCCGTTCAAGGACGAATCTCAGGATCTGGTGCCGGTGTCGAAGCTGGTGGACAACGCGACGAGCAACCAGGTGTCGTTCAACAGCTACTTTCGGCCCAGCGATGTGGCCAACCACATGGAGCAGAGCGACGAGGAGGGCCTCGTCGCCTCCGGCAGCGCCAGCGAGAGCAACAACTCCGGCACGGAGGACgtgaccagcagcagctgcaacgaGCCAAAGAAGAAATCCGCCTACAGCCTGGCCCCCAATCGCGTCAGCTGCCCCTACTGCCAGCGCATGTTCCCCTGGAGCAGCTCCCTGAGGCGGCACATCCTGACCCACACGGGCCAGAAGCCCTTCAAGTGCTCCCACTGCCCGCTGCTCTTCACCACGAAGAGCAACTGCGACCGCCATCTGCTGCGCAAGCACGGCAACGTCGAGTCCGCCATGTCCGTCTATGTGCCCGCCGAGGACGTCAACGAGCCCATTCCGGTGCCCAAGTCCGTCGAGGAGATcgagctggaggagcagcgGCGCCGCAAGGCCGCCGAGGCGGAGCAGCTCGAACGGGAGCGGGAGCgcgagcgagagcgagagagggagcgaGAAAGGGAGCGCGAGTTGGAGCGGGAGCGCGagcgggagcagcagcagctcatccaGCAGCTGGCCGCCGCGGCGCATCTCAGCCAGCAAATGgccgccgcagccgcagccgccgctgccgccgcctccagcaacaacaacagctcctCCGGCGGCGCCGTCGTGGGCAGTCCCAATGGCAGCGAGGCCAACGGCAGCGATCTGCCGTACAAGTGTCATCTGTGCGAGTTCTCGTTCGGGGAGCGGCTGCAGTGCCTCGAGCACATCAAGCAGACGCACGCCCATGAGTtcgcgctgctgctggccaaagGCGCCATCGAGACGGAGGCGCtgcacgagcagcagcagccgacgGCAGCCGGAGCAACTGCCTCCGACGATGAGTCCGCCGGCGGAGCTGGCGGCGGTGGCTCCCGTGCCGGCAAATATCCGGACTACAGCAACCGCAAGGTGATCTGCGCCTTCTGCGTGCGCCGCTTCTGGTCCACCGAGGATCTGCGCCGGCACATGCGCACCCACTCCGGCGAGCGGCCGTTCCAGTGCGAGATCTGCCTGCGCAAGTTCACGCTGAAGCACAGCATGCTGCGGCACATGAAGAAGCACAGCGGACGCAGCCACAACGGGGATCAGGGCCAGTCGGACTGCTCCGACGACGAGCAGCTGGCGACGCCGCCCTCCACGCCCAGtcccatgcccatgcccagctccaacagctccagcaacaacaacaacaacaacaacaccagcaacaacaacaacaacaacaacagttgccacaacaacaacaacaagcggcTGCCGAAGCTGCACGAGCTGCTGGACAAGGCGAACGAGTGGCGCGTCAGTCGCCTCGGCGAGCACAAGGAGAACCTGGGCGAGGCCACGCCCtccgccgcagcagccgccgccgcagcagccgtGGCCAGCGGAGATCTCATCGGGAATCTCCTCGGCATCAGCGACCAGGGCATCCTCAACAAGCTGCTCTCCTCCGCCGACGAGGCGGCCAAGCTGCTCGGCGTGGACAAGTAA
Protein Sequence
MLATQQQQQPTTTGAAAAATTASSTLGHGIDRVEMDLRQRRDSSTSESSLEHLDLGRTPKKLSSSSGAPQPTSTPHEAATATATSRKRKLRQQQQPQQLLQQPQHPFSDEDEQQQPQQPPQLEATVQRPRHKQRRSGNATAAASASIVVDYSASGDASSLRKKFRLNRSSASLSTNGELSESGFVDGSAHSGYLLSSSSNNSNNSNATAQSTTSATATAAAQQQASSSSSGGSSPHGLCMSSAESGIGAGDDHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQATTQSAGAMQQQQSQQQQSQQQQQQQQRRQQHVATEAVAATAGAGAQAAGARAESYESDASCSTDVSSAQSHSSSSSQANSNNSNNNNNNSHKTNNNNHSNNNNNNNEEELEVELELEEEQLERRAGGKQRRLKTTINNNIINDEEEDQEEEQQEHMDNDDADSVDVAQVITSTPDVATLLASEGTSPSHSPGPPLLLSCPACNAAEFESLPALCAHLDALHADIPAKCRECDVIFASHRQLQAHSCRAANGLPLMPPLGASSSPLHKQELEDEDEEQDEHELEREQQQRLEQALPSERDDFFQQLYLKGKSSQAQLPSPIKHEPADRQDLADIQSILNMTSSSCTSSFLRNFEQSVNTPCSSQYSVDGRDCEEEAQDAFTSEFRRMKLRGEFPCKLCTAVFPNLRALKGHNRVHLAAVGPSGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSRDEVKRAIVYHPAEDASCEDANTSSSNKSGSRLGEHDLSELSYRAQTPPPPPAAPAAEAASQLKHMLLAEPAAAAAAVAVKPEPPQPALKIQVKSLDQLVDKPVAPPTPAMDLSMDVLDLSKKPAAAAVAQELLEREREREHELLLQHQQQQQQREQQQQQQQQMFGAGDAASQYMQQLFRNLMFQQSPAFPFFSFMAPPPPAAADGKQQAAAAGATASPTAAAAAAAGLPLPLPLSGVGVGVPVPAGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRAASSNAAAAAAAAAAAAAAAAAMNNLSQQQHGHHGHHAPISEQVKYAILAQQLKARKDTDLLQQALAHGSSSVVANPLLHFSSYKNPNGNPNGATNGHRATPLAVDDDEPKLVIDEDDEDEFEDVDEEDELEEEEQQWKLEMEPEEEDEEPEEQEEQHQQLQEGEQPAEELQAHTPPMEAAKKVAETILEQAIKAGKSSEKEVEVAPEPAAPAAPMATPGAAPSAAAPNTMKTMIAQAESVAKSLKEVASSPFKDESQDLVPVSKLVDNATSNQVSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSCNEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPAEDVNEPIPVPKSVEEIELEEQRRRKAAEAEQLERERERERERERERERERELEREREREQQQLIQQLAAAAHLSQQMAAAAAAAAAAASSNNNSSSGGAVVGSPNGSEANGSDLPYKCHLCEFSFGERLQCLEHIKQTHAHEFALLLAKGAIETEALHEQQQPTAAGATASDDESAGGAGGGGSRAGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSMLRHMKKHSGRSHNGDQGQSDCSDDEQLATPPSTPSPMPMPSSNSSSNNNNNNNTSNNNNNNNSCHNNNNKRLPKLHELLDKANEWRVSRLGEHKENLGEATPSAAAAAAAAAVASGDLIGNLLGISDQGILNKLLSSADEAAKLLGVDK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-