Basic Information

Insect: Hirtodrosophila histrioides
Gene Symbol: zfh1
Assembly: GCA_037075165.1
Location: JBAMCL010000646.1:1993064-2022316[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.011 0.74 10.6 1.8 2 23 76 98 75 98 0.94

2 9 0.0015 0.1 13.3 0.1 1 23 280 302 280 302 0.97

3 9 3.6e-05 0.0024 18.4 1.8 2 23 316 337 315 337 0.97

4 9 0.00025 0.017 15.8 8.0 1 23 346 368 346 368 0.99

5 9 0.00024 0.016 15.8 1.8 1 21 374 394 374 395 0.94

6 9 0.034 2.3 9.1 0.4 2 21 613 632 612 633 0.92

7 9 1.7e-05 0.0011 19.5 0.5 1 23 978 1000 978 1000 0.94

8 9 6.3e-05 0.0042 17.7 7.4 1 23 1006 1028 1006 1028 0.98

9 9 0.0031 0.21 12.3 4.3 1 21 1034 1054 1034 1055 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.011	0.74	10.6	1.8	2	23	76	98	75	98	0.94
2	9	0.0015	0.1	13.3	0.1	1	23	280	302	280	302	0.97
3	9	3.6e-05	0.0024	18.4	1.8	2	23	316	337	315	337	0.97
4	9	0.00025	0.017	15.8	8.0	1	23	346	368	346	368	0.99
5	9	0.00024	0.016	15.8	1.8	1	21	374	394	374	395	0.94
6	9	0.034	2.3	9.1	0.4	2	21	613	632	612	633	0.92
7	9	1.7e-05	0.0011	19.5	0.5	1	23	978	1000	978	1000	0.94
8	9	6.3e-05	0.0042	17.7	7.4	1	23	1006	1028	1006	1028	0.98
9	9	0.0031	0.21	12.3	4.3	1	21	1034	1054	1034	1055	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTCCCTCTCTGGCCTCCAGTTTGCACCATCACCAAGCACACAGCAAGCCCAGCAATGTGGCTGCCAACCAGGAGCATGTGCCACATGCGGCCAGTGTCACAGCCAATGCAGCCGATGACTTTCTGGTCAAGTGCACGCAGTGCCACAAGCGCTTTAATGAGTTTCAGTCCCTCAGCGAGCACATTGCCAACGAGCATCCGCATGACAAGCTCAATTATGAGCCGCATCGTGCAACTGGCGCGGCGCAGCCGGAGAGTGAGGCGGAGGAGGATGAGCGTAGCAAtttgagcagcagcagtcgccggTATGCCAAGTCGCcatccaacaacaacaacaacaacagcgagacAGCCaagaatcaaaataataacaacaacaacagcaaccataGAAGTCAGCACTCACCTTTGTGCTCACCAGTTGCCCAGGCGCCCAGCGATCTGTTTGCCCACCTGCCGCACCCACCGCCGCAGTTGCCCGCCCATTTGCATGCACAGTTCATGGCAGCCGCTGCCCTGGCCATGCAATCTGCACGCTCCGCCAGCTCACCCAgtcagcagcaccagcaacagcaccagcaacagcaacaacaacagcaacacgcacagcagcaactgttgccgccgccgctaCCGGGCAGCAACAGTAGCGTAGGCAGCAATTCCGCCTACGATCTTGACTTGAGCGCACCGCGCTCCACCTCCAGCCCGGGCTCAACGACGGGCGATCTCAGCACGGCCTTTCCCTGCATGCAGTGCACGGCGGCCTTTGCCAGCCGGGAGCAACTGGAGCAGCATCAGCTGCTGCACTCGCCCACAGGCCAGCAGACCGCTCAGAATGTGACGCAGACATGCAAAATTTGCCACAAGGCATTCGCCAACGTTTATCGCCTGCAGCGTCACATGATCAGCCATGACGAGTCGGAGCTACTGCGCAAGTTTAAGTGCAATCTATGCACCAAGGCGTTCAAGTTCAAGCATCATCTCAAGGAGCACAAGCGCATCCATTCCGGAGAGAAGCCCTTTGCCTGCAATAAATGCGACAGACGCTTCTCACACTCGGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGTATTAACATGAATCAAAAGCTGAACAACAATCGACagagtttggacaaaaatgcCAGCGCTGGACGCTCACCAacgcatcagcagcagcagcagcagcaacttttgCCCGGAAAACGTGGCTGCAAGCTACCGGAGCAGGTGCTGCCGAATCCGATGAACTACTTTGCGGGCGAGGCGCAGATGCCCCCGGCAGGAGCCAATGGAGCCTTTTATCCCAATTATAGCGCAATGAATGCGGCCTTGTTGGCATTTCCGAATGCTTTTATGGCCGCAGCGCTGGATCCGCGCATGCATCCCTACAGCATACAGCGTTTGCTGGAGCTGACAGCTGccggacagcagcagcagcagcagcgcgagGAGCAACAGCCGCTTTATGAGTCCACCAAAGATGAAGATGAGACGCCAGATGAGCCCAAGCTAGTAATGGATCTGGAGGAGTCCGAAGTTAAGCCAGCAAACACGCCCGAGTTGCCAGCAGTCAAACCAACTGGCGATGATGCATCGGTCAAGCAGGAGCCCAGTCGTGAGCCTACGCCGGCGCTGCAAAGCGCACCCGATACGCCCAAGTCCATTAAAATGGAGCAAGATGAGGAAGCAGTGCCCGTGGAGCAGACTCGCGTCCAGACGCCACATGAACTCCGTTGCAGTCGCTGTGCCAAGCAATTTAATCATCCCACAGAGCTGGTGCAGCACGAGAAGGTGCTATGCGGGCTCATCAAggaggagctggagcagcattaccagcaacaacaacagcagcagcagcaacaacaacagcagtcaAACTTTGTGCTGCCTTCTGTTAGTGATGCCgacgaggatgaggaggaggaAGAGCCACGCCAGGACTACAATGCtggcagcagcgacagcggcgaGCGCAAAGTGCGCGTTCGTACCGCCATCAatgaggagcagcagcagcagctgaagcagcaTTACTCCCACAATGCGCGTCCCAGTCGCGACGAGTTCCGCCTAATCGCGGCTCGACTGCAGCTAGATGCGCGCGTTGTCCAGGTCTGGTTCCAAAACAATCGCTCGCGTGAGCGCAAGCTGCAGAGCTACAATGTGAGCAGCAGCGAGCAGCCAACCGATGCCGCACCCCCTGCACAGCCACGTGCTGGCGAGGATCAACCGCTTGATTTGTCTGTTAAGCGCGATGCATCGCCGCTGTATGGTCTGGCGCCACAGCCGGCGGCTGTAAGTCAAGCGCCCTCTGAATTTCCAGAGACCATGGCCATTAATCTGAGCCGCAAGCTGTCGAGCTCCGTTTCCATGTCGCCTGCTTCGCTGTCGCCATGCTCGGGCGCTTCTTCCTTGCAGCAAacggcagcggctgctgctgccgcggcGCTTTACTTTGCGCCGCCATCGCCGCCCGGTATGCATGAGGCGGTGCCCAGCATGCCGCCACACAATGCTGCGGCACGCGGTCAGCCCTTTCATGGTATACCGCCCTACATGATGCCCCGCCTGCCCATGGAGGCGCTCTTTCAGATGCGACCCGGCGGAGACTATGCGCCCAATCCGCTCATGAACAGTATTAAGCTGCCCGATTATCGCGGCACCAGCCTCAGTCCGGGCGGCTCTGAGAAGCGCTCGTGGCGCGACGACGATTCGCGTATTTCGCATGAGGATGACTACGTTTTGTCTGGCGCTGGACTCCTGCCGCCGAAGCCCAGACGCGCCAAGGCCGAAACGCATGGGCATGCGGGCGATCCGGATCTTCCGTTCGTCTGTGATCAGTGCGACAAAGCGTTTGCCAAGCAGAGCTCCCTGGCGCGCCACAAATACGAGCATTCCGGTCAGCGACCCTATCAGTGCATGGACTGCCCCAAGGCCTTCAAGCACAAGCATCATTTAACGGAACACAAGCGTTTGCATTCCGGCGAGAAACCGTTCCAGTGCTCCAAATGCCTGAAACGTTTCTCGCACTCGGGCAGCTACAGTCAGCACATGAACCACCGCTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFPSLASSLHHHQAHSKPSNVAANQEHVPHAASVTANAADDFLVKCTQCHKRFNEFQSLSEHIANEHPHDKLNYEPHRATGAAQPESEAEEDERSNLSSSSRRYAKSPSNNNNNNSETAKNQNNNNNNSNHRSQHSPLCSPVAQAPSDLFAHLPHPPPQLPAHLHAQFMAAAALAMQSARSASSPSQQHQQQHQQQQQQQQHAQQQLLPPPLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSTAFPCMQCTAAFASREQLEQHQLLHSPTGQQTAQNVTQTCKICHKAFANVYRLQRHMISHDESELLRKFKCNLCTKAFKFKHHLKEHKRIHSGEKPFACNKCDRRFSHSGSFSSHMTSKKCINMNQKLNNNRQSLDKNASAGRSPTHQQQQQQQLLPGKRGCKLPEQVLPNPMNYFAGEAQMPPAGANGAFYPNYSAMNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQQQQREEQQPLYESTKDEDETPDEPKLVMDLEESEVKPANTPELPAVKPTGDDASVKQEPSREPTPALQSAPDTPKSIKMEQDEEAVPVEQTRVQTPHELRCSRCAKQFNHPTELVQHEKVLCGLIKEELEQHYQQQQQQQQQQQQQSNFVLPSVSDADEDEEEEEPRQDYNAGSSDSGERKVRVRTAINEEQQQQLKQHYSHNARPSRDEFRLIAARLQLDARVVQVWFQNNRSRERKLQSYNVSSSEQPTDAAPPAQPRAGEDQPLDLSVKRDASPLYGLAPQPAAVSQAPSEFPETMAINLSRKLSSSVSMSPASLSPCSGASSLQQTAAAAAAAALYFAPPSPPGMHEAVPSMPPHNAAARGQPFHGIPPYMMPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDDYVLSGAGLLPPKPRRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00530857;
90% Identity: iTF_00805082;
80% Identity: iTF_00805082;