Basic Information

Gene Symbol
tsh
Assembly
GCA_037043425.1
Location
JBAMBM010000146.1:735862-746040[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.00037 0.023 15.3 0.5 1 21 341 361 341 365 0.92
2 3 0.00046 0.029 15.0 0.5 2 22 453 473 452 476 0.90
3 3 2.6e-05 0.0016 18.9 0.3 2 22 521 541 520 544 0.90

Sequence Information

Coding Sequence
atgttaCACGAGGCTTTGATGCTTGAGATCTACAGACAGGCGTTAAATGCCGGTGCCCTGCCTACAGCACGTCCACGTTCCACGGAATCGGCAAATTCCAGTGAGCGATGTCCTTCGCACGATTCCAACTCCTCCGAcaatggcggcggcggtggtggtggcaacTCCAGTGGCCAGCGAGATGGTCATGTAGGTGGGCTGGGCTCCGTGGTACCGACCACCCTGCATTCAACATTCCCGGCGGTGCCGCAATCGCTGCCCGCTCAGCCGCCCTCCATGGAGGCCTACCTGCATATGGTGGCCGCTGCGGCACAGCAGTATGGGTTCCCCCTGgctgcagcggcggcggctggACCGCgtttgccgctgccgctggccAATGAGGCAGCAGCACCATTCAAACTGCCACCGCAGGCTTCACCCACAGCATCGAGCAACCATTCCGAGGCTCTGGACTTTCGCACTAATCTTTATGCGCGCGCTGAATCTGCAGAACCGCCAGCTtctgaggaggaggaggactTTGATGACGGCGGCAACAATCCGCTGGATCTGTCGGTGGGCACACGCAAGCGCAGCCATGAGCCGGAGGGTCAGGCCAGCCATTTGGGGCAGATTCAGGtgaagaaaatgttcaaatcgGACAGTCCACCGGCGAATGCTTCGCCCTCGCCAGCCGCGGCACAGCTGTTGCCTGGAGTGAATCCGTATttggctgctgtggctgcggccAACATCTTTCGGGCCGGACAGTTTCCCGATTGGAATGGCAAGAACGATTTGGTTGTGGATCCTTTAGAGAAGATGTCCGATATTGTCAAAGGCAAGGAGAAGAGTGCAAAGTCAATGCCACAGCAAAATCAGCAGGCGCCACCAAAGAGCCCCGCCCAGCAGGCAAGCGAAGCAAGTGGAGGATCGGCCTCAGGAGGAGGTGGCAATGGCAGTGGTGGTGCTGTGACCAAGGCACGTCACAACATCTGGCAATCGCATTGGCAGAACAAAGGTGTGGCCAGTTCCGTGTTCCGTTGTGTGTGGTGCAAACAGAGTTTCCCCACCTTGGAGGCCCTAACCACCCACATGAAGGATAGCAAGCATTGCGGCGTGAATGTGCCACCATTTGGCAATCTGCCCAGCAATAATCCCAGTCAACAGCATAGcgcaccaccgccaccaccaccgcctgGACACAATCATCGCAAACCTAGCGGTGGTTCAAGTGGCAATCAGGGTCCTTCGGCCAATGTGAAGAATGCCTTTCAGTATCGCGGTGATCCGCCCACACCGCTGCCCAGGAAACTGGTGCGTGGCCAGAATGTGTGGCTGGGCAAGGGCGTGGAGCAAGCCATGCAGATCCTCAAGTGCATGCGCTGCGGCGAAAGCTTCCGTTCGTTGGGAGAGATGACCAAGCATATGCAGGAGACGCAGCACTACACCAACATACTCAGCCAGGAGCAGAGCATCTCCATCAAGTCGGCCAATGCTAACTCGTCGAACTCCGATCAGAAGGATGGTCAGGGCAGCCTTAGCTCCGAGGAAAGCCGCACTTTGAGCGCTGTGCTCACTTGCAAGGTTTGTGACAAGGCTTTCAGCTCTTTGGGGGATCTCAGCAACCACATGGCCAAGAACAATCACTATGCGGAACCGCTACTCCAATCTGCCGGCAATCGCAAGCGACCGGCTCCCAAGAAGCGCGAGAAATCCTTGCCTGTACGCAAGCTCCTCGAAATGAAGGGCGCCAATCAGGTGGAGGACATGCAGGCTGTGGAAAAATCAGGCCCCTCTCAAAACAAATCGGTTGGCGATAAGTCGGAGGCGGCCCTCTTTGCCGAACGCATGAGGCAGTACATCACCGGCGTCAAGTCACCCGAGGAGGCGGCCAAGGCCGCTGCGGCCGCTCAGCTGCTGGCCAAGAACAAGTCACCCGAACTGGAGAAGCTGGCTGCAGGCAATGGCAAGGCATCCGGCGGTGGTTCTGTGCTCAGCGCCATCGAGCAGATGTTCACCACCAGCTTTGATACGCCGCCACCGCGTCATGCCAGTCTGCCGGCCAGTAGCCCCTCGAACTCGTCCACCAAAAACACCTCGCCAGTGGCCTCCAGCATACTCAAGCGGTTGGGGATAGACGAGACTGTGGATTATAATAAACCACTGATCGACACCAGCGATCCGTATTTCCAGCACTATCGCTACACGAGCAGCGAACGCAGTGGTAGCGAATGCAGTGCCGAGGCGCCCAGGCCACGTGGCCATGAGGCTCCTAACACGCCCGAGAAGCCACAGCAGGCTGAGGTCGAAGCCAGCATCAAGCAGGAGAGGGAGCGGGAGCATGAATCAGTGGAGCAGAAAGCCTCCTCTATCAAAATGGAGATCAAGTCTGAGCTCAGCGATGAGCAGCACAATGAGGAGGCGGAGCACtccgccaacaacaaaatcgaaaGCACTCTGGTCAATGGCAActacagcaataacaacaacaataatgtggAACGTATTTCACCCAAATCttcaccagcagcaccagcagcgaGTCCACAATCACGTCTGCTGCCGCCACGCAGTCCAGCGGATAGCCAACGTTCGGCCACACCCAAATCGCCCGCTTCGAGTCACAAATCCTATGATGGGAGCAATGAAGGCAATAAGAAATATCCCAGTGATTCGCTCAATGCCTTGTCCTCCATGTTTGACTCCCTGGGCAGCTCCTCCAGCAGTGCTGCAGGTGCCACTCGGGCCAAGttggctgctgccgctgcagctgcctcgagtgtggctgctgttgtgggTGTTGGCGGTTCCGAGTCACCAGAGAATCTCAGTGCCAGCAATTCGTTGGCCGCCCTGCGTCAGTTCTGTGTGAAGAAGGAGAAGACCGCCTAG
Protein Sequence
MLHEALMLEIYRQALNAGALPTARPRSTESANSSERCPSHDSNSSDNGGGGGGGNSSGQRDGHVGGLGSVVPTTLHSTFPAVPQSLPAQPPSMEAYLHMVAAAAQQYGFPLAAAAAAGPRLPLPLANEAAAPFKLPPQASPTASSNHSEALDFRTNLYARAESAEPPASEEEEDFDDGGNNPLDLSVGTRKRSHEPEGQASHLGQIQVKKMFKSDSPPANASPSPAAAQLLPGVNPYLAAVAAANIFRAGQFPDWNGKNDLVVDPLEKMSDIVKGKEKSAKSMPQQNQQAPPKSPAQQASEASGGSASGGGGNGSGGAVTKARHNIWQSHWQNKGVASSVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPSQQHSAPPPPPPPGHNHRKPSGGSSGNQGPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKSANANSSNSDQKDGQGSLSSEESRTLSAVLTCKVCDKAFSSLGDLSNHMAKNNHYAEPLLQSAGNRKRPAPKKREKSLPVRKLLEMKGANQVEDMQAVEKSGPSQNKSVGDKSEAALFAERMRQYITGVKSPEEAAKAAAAAQLLAKNKSPELEKLAAGNGKASGGGSVLSAIEQMFTTSFDTPPPRHASLPASSPSNSSTKNTSPVASSILKRLGIDETVDYNKPLIDTSDPYFQHYRYTSSERSGSECSAEAPRPRGHEAPNTPEKPQQAEVEASIKQEREREHESVEQKASSIKMEIKSELSDEQHNEEAEHSANNKIESTLVNGNYSNNNNNNVERISPKSSPAAPAASPQSRLLPPRSPADSQRSATPKSPASSHKSYDGSNEGNKKYPSDSLNALSSMFDSLGSSSSSAAGATRAKLAAAAAAASSVAAVVGVGGSESPENLSASNSLAALRQFCVKKEKTA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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