Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 5.6e-05 0.0035 17.9 0.9 1 23 174 196 174 196 0.96

2 5 1.8e-06 0.00012 22.5 4.8 1 23 202 224 202 224 0.98

3 5 1.1e-05 0.0007 20.1 2.1 1 23 230 252 230 252 0.99

4 5 0.00097 0.061 14.0 1.2 1 23 258 280 258 280 0.98

5 5 0.002 0.13 13.0 7.9 1 23 286 308 286 308 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	5.6e-05	0.0035	17.9	0.9	1	23	174	196	174	196	0.96
2	5	1.8e-06	0.00012	22.5	4.8	1	23	202	224	202	224	0.98
3	5	1.1e-05	0.0007	20.1	2.1	1	23	230	252	230	252	0.99
4	5	0.00097	0.061	14.0	1.2	1	23	258	280	258	280	0.98
5	5	0.002	0.13	13.0	7.9	1	23	286	308	286	308	0.98

Coding Sequence: ATGGAGGAGGCAGAACTCTGTCGTATTTGCCTGCTGCAGCCTAAGGACCAGACACTTATGCCAACCGACGGCAATTTGTTTTATCAGCAGATTGAAAGTTGCACTGGCGTTCAGTTAAGTCTGTGGGATTCGTGGTCCAACAAGATATGCACCAACTGTTCCTTGTTGCTGCGTGCAGCTCTTAAACTGCGTGATCTGTGCCTGCAATCCGAGGAGGTATTGCAGTCACAAAAGATGAAGATGGAGGAAATTGAGATGGAGACACCTTCATCACctcagctggagcagcagcaagatgAAGAGGAGCACCAACTGGAACAGAGTGACAATGTTAAGGATATGGAAGGAGATGGTGATTTGGTGAAGTACTACCAAGTCACTTTCTTACCCACAGACAGTGATGGCGATGCCACACCGCAAGCAAACACTGCAGCTCATATATCTATAGCTCCTATGGAGCGTAAGCATGGCCGCTTCCAATCGACAACTTCCGACAGCCACAAGCCACTTGCCATCTCCTATTTGTGCAACATTTGCCACAATGTCTATACGAGCAAGGTGAAGCTGGCGGTCCATATGAAGGTGCACAGTGACTTCAAGCCGCATGAGTGCGAGATCTGTCACAAGCGTTTCCGCCAGACGCCACAGCTGACGCGGCACATGAACTCGCACACGGGACTGCGTCCCTACAAATGCGATTACTGTGATTCTTGTTTTGCAGATCCCTCCACGCGCATCAAGCATCAAAGGATTCATACAAATGAGCGTCCCTATAAATGTACATTTTGCAACAAGGCCTTTGCCTATTCCAATGTGCGCAATGTCCATCTCAAGATCCATACGGGCGATCGACCATTTAGCTGTGATTACTGCGACAAACGCTTTTACCAATTGCATCATAAGAAATCCCACGAGCGTTCCCATAAAGACATTATTATAAACATTGCTGAGGTCAGCACAATGGcggaggaggaagaggaggagtGA
Protein Sequence: MEEAELCRICLLQPKDQTLMPTDGNLFYQQIESCTGVQLSLWDSWSNKICTNCSLLLRAALKLRDLCLQSEEVLQSQKMKMEEIEMETPSSPQLEQQQDEEEHQLEQSDNVKDMEGDGDLVKYYQVTFLPTDSDGDATPQANTAAHISIAPMERKHGRFQSTTSDSHKPLAISYLCNICHNVYTSKVKLAVHMKVHSDFKPHECEICHKRFRQTPQLTRHMNSHTGLRPYKCDYCDSCFADPSTRIKHQRIHTNERPYKCTFCNKAFAYSNVRNVHLKIHTGDRPFSCDYCDKRFYQLHHKKSHERSHKDIIINIAEVSTMAEEEEEE

Sequence clustering based on sequence similarity using MMseqs2