Basic Information

Gene Symbol
Bcl11a
Assembly
GCA_031772345.1
Location
CM062837.1:10216953-10218419[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0037 0.18 12.6 0.2 2 23 173 194 172 194 0.97
2 11 1.1e-05 0.00052 20.6 3.1 1 23 200 223 200 223 0.98
3 11 0.00031 0.015 16.0 0.7 1 23 234 256 234 256 0.97
4 11 5.1e-06 0.00024 21.6 0.6 1 23 262 284 262 284 0.98
5 11 5.7e-06 0.00027 21.5 0.2 1 23 290 312 290 312 0.97
6 11 4e-06 0.00019 22.0 1.0 1 23 318 340 318 340 0.98
7 11 2.4e-06 0.00011 22.7 0.2 3 23 348 369 346 369 0.96
8 11 0.31 15 6.6 0.8 5 23 375 393 373 393 0.91
9 11 5.6e-06 0.00027 21.5 1.8 2 23 400 421 400 421 0.97
10 11 0.036 1.7 9.5 1.7 1 23 427 452 427 452 0.87
11 11 1.3 61 4.6 9.9 1 23 458 480 458 481 0.95

Sequence Information

Coding Sequence
ATGGAAAGTAGCGATAGCGATGATATCTGCCGTATATGTTTACAACACGGCAAACCGATGACATCCGTTTTTGAATTTGATGACTCCTTGCAATACTCACACAAAATTATGCACTGCGCCAGGATACAAATCTCTGAACTCGAGGATTTGCCCTCAGTTATATGCAAAGAATGCCGGTCGCACTTGACCGTAGCTTACGACTTTGTTATCAAATGTCAAAACTCTGACGAAGACCTTCGGAAATCTTaccacttaaaatatgtaaagccGGGAGAAGACACGGACGTGTCAGTGAAATATGAAGAGGAGAGTGTAAGTTTTGAATACGAAAATAACAAGCATGAAGAAATATGCGATGCTGAGCCAATCGTAAAACAAGAACGGCGGCAAACTACGTCCAAACGCGggataatttcaaatttagaatacGTCGACGAAGGGTCTGTTGCTGAGTATGTTCCGTTAACGTCAATCAAGAGGGAACAGAAAAAGCCTCTCGCTACGAAAAGCGAAGTAACGTGTCGAATCTGTAGCTTACGAACCAGCAGTGTGTCAGCTTTGATAATTCACACTAGGACGCATACTGGTGAGAAACCCTTTCGGTGTCCCACATGTGGTTCATGTTTTTCACAAAACGGCACACTAAAAATGCACATTAAAAGACGACATTTAGACGATAAGAAAAGTAAAGTCAGGGAATTCGCCTGCGATAAATGCGGTAAACTATTCGTTAGCAAAAGAGACATCACCATCCATTTTAGAATGCATACAGGTGAGACGCCGTACGCTTGTCAAAGTTGTCCGAAAAAATTCACGCAGCTAGGATCCCTCATTCGTCACCGAAGAATACATACTGGCGAGAGACCATTCCCTTGCCCGGTTTGCGGAAAATGTTTCATTGATAGGTCCGTACTAAAAATGCACGCCCTGGTCCACAGTGAGGCAAGATTATTTACATGCAATGTTTGCGGGAAATCTGTCAAGTCGAAAAATACACTCATTAAGCATTTAAACCAACACAAAGATTACAAGCCCGTGATATGTGATCAATGCGGTGCCGTGTTTTCTACGAAAGGCAATCTGACGATGCATCTTCGGAGATTTCATTCAGAGAAGTCGGGAATATGTTCTGTTTGTGCGAAGCATTGTCCTGATTTAGTTGCGCATATGCGAAGACATACAGGAGAAGAGGCGGCTTCctgtaaaatatgcaataaacgaTTCAATCAGAAGCGAAGTTTGGCTGTGCACATGAATAACCATGCCAATGCGAACAGATTTAAGTGTGACGAAGAAGGATGCGGGAAAATGTTTCGCCTTCAACATATGCTCAATTTCCACACTGTGAAATATCACTCCCGCAATATTCCTTTCCATTGTAAACTGTGCAACAAAGGTTGCCTTCGTAAATGCGATTTGAAGAGGCATATCGCGAATCATCACACCGAGtcaaaaataacagtttaa
Protein Sequence
MESSDSDDICRICLQHGKPMTSVFEFDDSLQYSHKIMHCARIQISELEDLPSVICKECRSHLTVAYDFVIKCQNSDEDLRKSYHLKYVKPGEDTDVSVKYEEESVSFEYENNKHEEICDAEPIVKQERRQTTSKRGIISNLEYVDEGSVAEYVPLTSIKREQKKPLATKSEVTCRICSLRTSSVSALIIHTRTHTGEKPFRCPTCGSCFSQNGTLKMHIKRRHLDDKKSKVREFACDKCGKLFVSKRDITIHFRMHTGETPYACQSCPKKFTQLGSLIRHRRIHTGERPFPCPVCGKCFIDRSVLKMHALVHSEARLFTCNVCGKSVKSKNTLIKHLNQHKDYKPVICDQCGAVFSTKGNLTMHLRRFHSEKSGICSVCAKHCPDLVAHMRRHTGEEAASCKICNKRFNQKRSLAVHMNNHANANRFKCDEEGCGKMFRLQHMLNFHTVKYHSRNIPFHCKLCNKGCLRKCDLKRHIANHHTESKITV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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