Hano004762.1
Basic Information
- Insect
- Himalopsyche anomala
- Gene Symbol
- HSFX4
- Assembly
- GCA_031772345.1
- Location
- CM062824.1:31443016-31447242[-]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 1.6e-23 1.7e-19 70.4 0.1 1 100 13 113 13 113 0.86 2 5 0.36 3.8e+03 -1.3 0.1 16 41 153 179 143 208 0.74 3 5 0.18 1.9e+03 -0.3 0.0 13 37 198 222 184 234 0.73 4 5 1.9 2.1e+04 -3.7 0.0 17 33 266 283 260 289 0.62 5 5 0.81 8.8e+03 -2.5 0.0 58 82 302 328 301 332 0.64
Sequence Information
- Coding Sequence
- ATGTCAAACGACGAATCACCCGCTAGTCGCTTGTTATTTCCACAAAAGCTATGGCATTTGATGAATGCCAGAAGCGATGCGATCCAGTGGGGAAATAATGGACACACAATATTATTGAACTACAACATCTTGGATAATTATTTGAGATGTAaccaatcgatttttaaaactaatcatATCTCCAGCTTTATTCGTCAGTTGAATTTATATGGTTTTCGTAAAGTAACGTCACACATGCAAGACCCTTTGTGCAATTCTAGCAATCCGTATTTACACGAATATATACATGATTGTTTTCAACTTGGAAAACCTGATCTGTTACCAATCATCAAAAGGAAATCCTGGAATGTGAACAAAGCTCCCATTTTTCAACTGCCTTATGTTGAAGTATCTGGATGCTACAAGAGTAAAGTTGTTCTGGATGCTCGAAAAGCTCTGAAGAACGCCTTAAAAAAAGCTGCCCGTCAGTGGATAAATGATAAATCTGATATCCATGTCAGCTCGAGTGAGGAAGAAATGGAACAGGAAACTATGAATGCAAGTGAGCAGACGACTGTGTGTGAAGTTATTGAAGACAGGTATTATGAAGAAGCCGAAGAGCAACACTCCAGTTATCAAATGAACGGAGAGTCGTTTGAAGTGTATCAAGAAGAACATGTGTGCAGTGACACATACGTTCCACAGTCTGAGACATATACAGAAGACGATCAACAGTACAGCGGGAATATCATCATCGAAGTATTGGATGAAACTGAATGCGACACTTTGGGTGAGGAAATTTACAATGAGAATCAACTCATTGAGAATACGGAGAATGATGGCAGTCAGTTTCTCGTTAAAGCTGACGAGTCTACTTACGAATCATGTACAGTCGAGGACGACTACGTTGATGAGAGTGAAGAGAAATATGATTTTGAGCAGGCATGCATTGAGAACTCGGTCATGAATGACCACGAAGAAGTCGGCTCGCCGTGGGAATATACTGAAACTATCTTAGGCGGAGACGGTCGCGTCGTTGAGGCATATCAATTGCAGAATGAAAACCATACCGTCAACGAATGGAAAGAACTCTACTGCCAAATTACTAACACTATGGACTTATTGCAATCTTAA
- Protein Sequence
- MSNDESPASRLLFPQKLWHLMNARSDAIQWGNNGHTILLNYNILDNYLRCNQSIFKTNHISSFIRQLNLYGFRKVTSHMQDPLCNSSNPYLHEYIHDCFQLGKPDLLPIIKRKSWNVNKAPIFQLPYVEVSGCYKSKVVLDARKALKNALKKAARQWINDKSDIHVSSSEEEMEQETMNASEQTTVCEVIEDRYYEEAEEQHSSYQMNGESFEVYQEEHVCSDTYVPQSETYTEDDQQYSGNIIIEVLDETECDTLGEEIYNENQLIENTENDGSQFLVKADESTYESCTVEDDYVDESEEKYDFEQACIENSVMNDHEEVGSPWEYTETILGGDGRVVEAYQLQNENHTVNEWKELYCQITNTMDLLQS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -