Basic Information

Insect: Hesperia comma
Gene Symbol: topi
Assembly: GCA_905404135.1
Location: FR990028.1:2006775-2014170[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.0026 0.29 12.4 0.9 1 23 281 303 281 303 0.98

2 12 0.00017 0.019 16.1 2.2 2 23 311 332 310 332 0.94

3 12 0.055 6.3 8.2 1.4 1 23 336 358 336 358 0.97

4 12 0.0003 0.034 15.3 0.9 1 23 363 386 363 386 0.98

5 12 0.0071 0.82 11.0 0.2 1 23 390 413 390 413 0.94

6 12 0.0077 0.89 10.9 0.2 2 21 426 445 426 450 0.92

7 12 3.8e-05 0.0044 18.1 0.4 3 23 459 480 459 480 0.98

8 12 0.071 8.1 7.9 0.2 2 23 500 522 499 522 0.96

9 12 2e-06 0.00023 22.2 0.4 1 23 533 555 533 555 0.99

10 12 4e-06 0.00046 21.2 4.1 1 23 561 583 561 583 0.99

11 12 0.00041 0.047 14.9 1.3 1 23 589 611 589 611 0.96

12 12 1.1e-05 0.0013 19.8 0.2 1 23 617 640 617 640 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.0026	0.29	12.4	0.9	1	23	281	303	281	303	0.98
2	12	0.00017	0.019	16.1	2.2	2	23	311	332	310	332	0.94
3	12	0.055	6.3	8.2	1.4	1	23	336	358	336	358	0.97
4	12	0.0003	0.034	15.3	0.9	1	23	363	386	363	386	0.98
5	12	0.0071	0.82	11.0	0.2	1	23	390	413	390	413	0.94
6	12	0.0077	0.89	10.9	0.2	2	21	426	445	426	450	0.92
7	12	3.8e-05	0.0044	18.1	0.4	3	23	459	480	459	480	0.98
8	12	0.071	8.1	7.9	0.2	2	23	500	522	499	522	0.96
9	12	2e-06	0.00023	22.2	0.4	1	23	533	555	533	555	0.99
10	12	4e-06	0.00046	21.2	4.1	1	23	561	583	561	583	0.99
11	12	0.00041	0.047	14.9	1.3	1	23	589	611	589	611	0.96
12	12	1.1e-05	0.0013	19.8	0.2	1	23	617	640	617	640	0.98

Sequence Information

Coding Sequence: ATGGCAGAGCTAAAAGTTTGCAGGATATGCCTTATTACGGAGGTCAAGATGTACGATTTGCGTTCGTACCCTCTGAGCACTTACTACGAACCGATTACTGGGATCAATCCTCTAGGGGAGTACTCCCTGCCTATGTTTGCCTGCTACGAATGCACCTCACTGATAAAGAAGTTTTACAACTTCAGAGAGAAGTGTCTCCGTGGCCAGGCCACATTGTATGCAATACTCCAGTTTAATGATAAGATTACAGCCGATGACATAAAGAATATAGACAGGCAATCATTCTTCCTGTGCCCTACCCTAGCACTGCATAACATATCTGAGGAGAATATTATTTGTTGTAAACATGAAGATTTGGACATCAAAGATGAACCATTTGAGAAAGTGGACAATACTGTGTTTTGTAACGAAGACATAGATAATATCAAGCAGGAAGACAGTGGGGATGACTTCGCAGGTCTGTCTAGTGACAATGAAGACATCCCTCTCTCTCTTCATAAGACTAATAAGGAGAAGAAAGAGAAAGTTGTTAAGAAAGTAAAAGTGAAGAAAACTGAAGAATTAGAAGATACAGCAGACATAAAGGATGATGTCGTACCTGAGAAGGTAGTGAGTGTTAAAAGTGCAACATCAAAAGGGGAGAAAGGTAAGCGCGGGCGGCCGAAGAAGGTGCCGCAAGGGACGCGGCAGCCGAAGTCGCGCCGCACGCAGAACACGGGCGGGGTGGTGGATGAAGACCTGGACCTCACCGAGTTTGTCACTGTCATGACGCTTTCGATCGAGGAGCAGAAGGAGGACATAGTGAAGCGGCAGTCGTCGTCCAACTACGTGAACGCGCCGTACAAGTGCGGGCTGTGCTACAAGGGGTTCATCGACACGGACGCCTGGAACCACCACGTCAGCAAGCACGACCCCAAAGCGGGTGATATGGAGTGTCCCATATGTAAATTCCGGTTCAAGAGCAAACGGTCCCTGCAGAAACACTCGTCCAACCACGGGAAGAAATACGCCTGCAAATCCTGTTCCTATGTCTCGAAGACTACAACTCAGGCAAAACAGCATCAGAGATGGCACGAGGGAGTCACATACAAGTGTCAGTACTGCGATGAGGTTTCCACCAAGTGGACGTCATACCTGAGCCACGTGCGCATTAAGCACCCGTCGGAGTTCATCTGTGGCGCGTGCGGCTACTCCTTCGTCAGCCGCCTCGGGCTCACCATGCACCGCACCATGATGCACAAGGACATCGTGGATAAGACCGAGGAGAGCGGGCCGTACTGCGAGCAGTGCGACGTCAAGTTCATATCGGAGGAGGCCTGGAAGAGGCACATGGTCACCTCCGTCAAACATACCAAGGGGAAGAACCTGAACGGGTGTCGTGTGTGCGGCGAGTCGTTCGCCAGCGCAGAGTTACTGCGCGTGCATCACCGTACGGCGCACGCGCGCAAGCGGCCCAAGAACTACGGAAAGCCGCCCTCCAACACCACCTGGCCCTCGCCCTGCGAACACTGCTCGGAGGTGATCCCGAACGCGCGCGAGTACTGGACGCACTTCCGGCGCGCGCACCCCGACAAGCACTACCCCATCGAGAAGAACTACGTCTGCGACATCTGCGGGAAGAGCTTCCGGGGCAACGCGTTCCTAGTGTACCACCGGCGCACGCACTCGGAGACGAAGGAGTACTCGTGCGGCGAGTGCGGCAAGGCGTTCCACAACCGGACCAACCTGCACGTGCACCGGCGCACGCACTCGGACGAGCGCCCGCACGCCTGCTCCGTCTGCCGCAAGGCGTTCAAGGGCAAGGGCGCGCTGGATCGACACTTCCGGAGTCACACAGGCGTGAAGCCGTACGAGTGCGAGGTGTGCGGCAAGGCGTTCGCGCAGTCCAACAGCCGCAAGCTGCACGTGCGCACCGTGCACCTCAAGCAGCCCTCGCCGTACATCAGCCGCAGCCGCCTCGAGAAACGGAACAAGGCGCTCGCGCAGAAGGAAATGCCGCCCGCCGACTATTTGTACTAG
Protein Sequence: MAELKVCRICLITEVKMYDLRSYPLSTYYEPITGINPLGEYSLPMFACYECTSLIKKFYNFREKCLRGQATLYAILQFNDKITADDIKNIDRQSFFLCPTLALHNISEENIICCKHEDLDIKDEPFEKVDNTVFCNEDIDNIKQEDSGDDFAGLSSDNEDIPLSLHKTNKEKKEKVVKKVKVKKTEELEDTADIKDDVVPEKVVSVKSATSKGEKGKRGRPKKVPQGTRQPKSRRTQNTGGVVDEDLDLTEFVTVMTLSIEEQKEDIVKRQSSSNYVNAPYKCGLCYKGFIDTDAWNHHVSKHDPKAGDMECPICKFRFKSKRSLQKHSSNHGKKYACKSCSYVSKTTTQAKQHQRWHEGVTYKCQYCDEVSTKWTSYLSHVRIKHPSEFICGACGYSFVSRLGLTMHRTMMHKDIVDKTEESGPYCEQCDVKFISEEAWKRHMVTSVKHTKGKNLNGCRVCGESFASAELLRVHHRTAHARKRPKNYGKPPSNTTWPSPCEHCSEVIPNAREYWTHFRRAHPDKHYPIEKNYVCDICGKSFRGNAFLVYHRRTHSETKEYSCGECGKAFHNRTNLHVHRRTHSDERPHACSVCRKAFKGKGALDRHFRSHTGVKPYECEVCGKAFAQSNSRKLHVRTVHLKQPSPYISRSRLEKRNKALAQKEMPPADYLY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00970602;
90% Identity: iTF_01438245; iTF_01439246; iTF_00970602; iTF_00971553; iTF_01082675;
80% Identity: -