Hlin006200.1
Basic Information
- Gene Symbol
- ZFX
- Assembly
- GCA_026182355.1
- Location
- JAPFBL010001930.1:790544-792520[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 13 2.1e-05 0.01 18.2 2.1 2 23 237 259 236 259 0.95 2 13 2 9.1e+02 2.6 0.7 1 23 291 313 291 313 0.91 3 13 0.00072 0.33 13.4 0.1 2 23 321 342 320 342 0.96 4 13 0.59 2.8e+02 4.2 4.5 3 23 351 372 349 372 0.93 5 13 0.038 18 8.0 0.1 2 23 379 401 378 401 0.95 6 13 6.1e-05 0.028 16.8 3.5 1 23 407 430 407 430 0.95 7 13 0.0059 2.8 10.5 1.2 2 23 434 455 433 455 0.96 8 13 3.8e-05 0.018 17.4 0.2 1 23 463 485 463 485 0.94 9 13 0.32 1.5e+02 5.0 0.1 3 23 493 513 491 513 0.86 10 13 0.0018 0.83 12.2 2.5 1 23 519 541 519 541 0.97 11 13 3.7e-05 0.017 17.5 2.0 1 23 547 570 547 570 0.97 12 13 1.7e-06 0.0008 21.7 1.7 1 23 576 598 576 598 0.98 13 13 1.1e-05 0.0051 19.1 1.5 1 23 604 627 604 627 0.96
Sequence Information
- Coding Sequence
- ATGTTATCTGCTAAAAATCAGGTTCTCTTTGTAAGTGAAGGTAAGAAAATGGTACCTTTGTGTTTTGTTTGCGGTCAAGAATTAAAAGAAGATAGTCGGAAAATTGTAGAAACAAAAACTCAATGCCAAGGAATTCCCTTGCCTAATAAATTGAGCAATTTAATTGGTGATGATTTCTATGTTGTAGTGTCAATGATTGATGAGGTATGTGATAGTTGCATCAAACTTATTGACAAAGTCGACAAACTAGAAGAAAATTTAACAGAATTGAAGCAGAAAATTGTAAAAATGCTGCAAGTAAAATATGAAATAAATATTCAGGAAACACCAACCAGTGAGCAAGACTGCATTGTTATTAATAGTTCTAGTGACGGTCAATTGACTGGTGTAACAGAATCTCAAGAAAATACCAACAATGATAATTACCTTATTGAGTCCTGCAATCTTGAGGAGAATTGTACTGACAGTAACAGAGAAATTGGTCACATTACAGAAACTAAAGTTCCCTCTAAGAAATATTGTTCAGACACTGACTATAAGTTGCATGTACAAAAGAACCATTGCTTGGACGGAGTAATAAACTCAGATTTCACCTCGTTTGCTATTAATGAAGCCAATGAAATTTTATATGATGGAAAATATGAATTTTCTAATCAGTTTTATTCGGAGCCTGGAGGAATTTTAGATCCGTCAATTAAAGTTGAACTAGTTTGTGGGCATTGTACAAAAACTTTTAAGACTGAAGACGATTTGCATCAACATATTGAATCTGAACATAATAATGGAAGTAGTGAGACAACTGCCGCTAAAGACACTAATGAGTACAATGATTCCCAAATTGACGTTAGTGAAACTCAAAACACTACTACTTACAATTGTATGAAATGTGGATTTACGAACGAAGATAAGGAAGTTGTAAAAAAACATTTGGAATACCACTTCGTTTCAAAAAAGCCTGTTGTGTGCGATATTTGTGAAATGCCTTTTCCAACTACATCTGTCTTGAATAGACATTTCAAGGTACATGCAAAGAGTGAAGGTCCAGTCATTTGTAATATATGTGGTAAGCAGTGTCATGACTCTCTTCATGCCAACTATCACAGGAAAAATGAGCATAATTTGCTTCAAGAAATATCTTGTGGCCTTTGTAACATGCCCATGGATTCAAATGTTGAATTGAAGAATCATATGCTAATGATGCATAGAGGAAAAAAAGAATACAAATGTAAAGAGTGTAACAAAATATTCACACGTCATGTACAGTATGAAAATCACAAACTGTATGCTCATGGTAATTCCCAATGCAGGATTTGTGGAAAATATATTTCTGATGCCGTGAAATTAAGACAGCATGAACATCGCCACGCACGTACTGATATGAATAAGTTTGAATGTGAAGTGTGTAAAAGAACATTTAAAACTGCTGGTGGTCTCAGAGTACATAGCGTAAGTCACACGGGAAAATATAAATTATTTTGTGAATTTTGTGGTCGTGGATTTATGTCCAGTGTAATCCTTGAGGAGCATAAAGGGGTTCATACTAAAGAAGAGAGGTATGTGTGTGACACATGTGGAAGGAAATTCGTTTTATACAGTACATTCCATTTACATAGACAGTGGCATAAAAACCCTTATCCTTTCCCATGCAGAGTTTGCGATAGAAAATTTAGATATAGATCCGAAAGATCGAATCACATGAGAAGAGTTCATACTGGCGAAATGCCCCACAAATGTCCGTACTGTGATGCAGCTTTTATAAAAAGCAGCTATCTAAAAAAACACATAACTAGTCATACGAAAATGTACCCTTTCAACTGTGAAACTTGTAAAAAAGGATTTGATCAGAAAAGGACGCTTGCTAGGCACATGTCTAAGGTACATGCTGACAATTCTTTACTCCTTTCAATGCCCAAACCATGTCAATATAAAGTGGCTCTTCGACCAGAGGAATATCCTGAAGAAGTCGATACGAGTTAA
- Protein Sequence
- MLSAKNQVLFVSEGKKMVPLCFVCGQELKEDSRKIVETKTQCQGIPLPNKLSNLIGDDFYVVVSMIDEVCDSCIKLIDKVDKLEENLTELKQKIVKMLQVKYEINIQETPTSEQDCIVINSSSDGQLTGVTESQENTNNDNYLIESCNLEENCTDSNREIGHITETKVPSKKYCSDTDYKLHVQKNHCLDGVINSDFTSFAINEANEILYDGKYEFSNQFYSEPGGILDPSIKVELVCGHCTKTFKTEDDLHQHIESEHNNGSSETTAAKDTNEYNDSQIDVSETQNTTTYNCMKCGFTNEDKEVVKKHLEYHFVSKKPVVCDICEMPFPTTSVLNRHFKVHAKSEGPVICNICGKQCHDSLHANYHRKNEHNLLQEISCGLCNMPMDSNVELKNHMLMMHRGKKEYKCKECNKIFTRHVQYENHKLYAHGNSQCRICGKYISDAVKLRQHEHRHARTDMNKFECEVCKRTFKTAGGLRVHSVSHTGKYKLFCEFCGRGFMSSVILEEHKGVHTKEERYVCDTCGRKFVLYSTFHLHRQWHKNPYPFPCRVCDRKFRYRSERSNHMRRVHTGEMPHKCPYCDAAFIKSSYLKKHITSHTKMYPFNCETCKKGFDQKRTLARHMSKVHADNSLLLSMPKPCQYKVALRPEEYPEEVDTS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -