Basic Information

Insect: Hermaeophaga mercurialis
Gene Symbol: LARGE1
Assembly: GCA_951812935.1
Location: OX638360.1:49317577-49326705[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.012 1.4 10.4 1.2 1 21 167 187 167 188 0.94

2 12 0.00019 0.023 16.0 4.4 1 23 196 218 196 218 0.99

3 12 1.1e-07 1.3e-05 26.3 0.4 1 23 224 246 224 246 0.98

4 12 0.00012 0.015 16.6 3.2 1 23 252 274 252 274 0.98

5 12 0.0016 0.19 13.1 2.6 1 23 280 302 280 302 0.98

6 12 0.048 5.7 8.5 0.1 2 23 313 334 312 334 0.96

7 12 7.4e-06 0.00088 20.5 0.8 1 23 342 364 342 364 0.98

8 12 7.4e-07 8.7e-05 23.7 3.0 1 23 370 392 370 392 0.98

9 12 1.3e-06 0.00015 22.9 0.7 1 23 398 420 398 420 0.99

10 12 4.8e-05 0.0056 18.0 1.8 1 23 426 448 426 448 0.99

11 12 1.6e-05 0.0018 19.5 1.1 1 23 454 476 454 476 0.98

12 12 0.0003 0.036 15.4 1.5 1 23 482 505 482 505 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.012	1.4	10.4	1.2	1	21	167	187	167	188	0.94
2	12	0.00019	0.023	16.0	4.4	1	23	196	218	196	218	0.99
3	12	1.1e-07	1.3e-05	26.3	0.4	1	23	224	246	224	246	0.98
4	12	0.00012	0.015	16.6	3.2	1	23	252	274	252	274	0.98
5	12	0.0016	0.19	13.1	2.6	1	23	280	302	280	302	0.98
6	12	0.048	5.7	8.5	0.1	2	23	313	334	312	334	0.96
7	12	7.4e-06	0.00088	20.5	0.8	1	23	342	364	342	364	0.98
8	12	7.4e-07	8.7e-05	23.7	3.0	1	23	370	392	370	392	0.98
9	12	1.3e-06	0.00015	22.9	0.7	1	23	398	420	398	420	0.99
10	12	4.8e-05	0.0056	18.0	1.8	1	23	426	448	426	448	0.99
11	12	1.6e-05	0.0018	19.5	1.1	1	23	454	476	454	476	0.98
12	12	0.0003	0.036	15.4	1.5	1	23	482	505	482	505	0.96

Sequence Information

Coding Sequence: atggCTTTTAACGCTTTACAATTTTTAGTTAAAGAAGAACCAAAAGAAGCGGATCTAAATGATCAAAATGTTATTACTAATATTGGGATCAAAGTTAAAGAAGAAGGAGACTACTTGCCAGACAACCCAGATTTGGTGGATTTAGGAAATACTACAAACGGGATTCTCCCTCAAGTATGGAAAGAAGGGTGTTATAAAATTGATTCAAGCAATACACCTACTAATGAAACATTATCAGAATCTACTGAGGGCACTAAATTTAATGCTCAGGAATGGTCCAACAAATACTTAACTACCCTAGCCAATAGtctaaataaaactttaatagatGCAAGTACTTCAGGAGGTGAAATAAATGAAACTGATTTATCGAATAGTAGTGAATTGGCAACAAGAAATCTACAACATTTTATGTTAGATGAGAATTCAGAAGACAGCACGCAAGATACAAATAGAACTGATTCTGACCAAGATTGGACTGAACATAAAGATggttatttttcttgtaaaatttgCAAAGTACGGTTTCCTGACGAGTTTTACttacaaaatcattttaaatacagaAGACTAGGAGATAAAAGTTACAAATGTTGTAGTTGTGATAAAATAttcagGGATAACACTCAGCTAAATGTGCACTCTAGGAAACACACTGGTGAAAAACCATATGCTTGTACAGTTTGTGGCAAAAAGTTTTCCGTCAATGGAAATTTGAGTAAACACATGAGAATACATACAGGCGAAAGAAGATTTGAATGTTTCACATGTGAAAGAAAATTTACCCAATTTGCTCACTTAGAGGACCACATTAAAACCCATTCCGgagAAAGGCCATATATTTGCGATTTTTGCAACAGTGCCTTCAAAACTAAGGCTAGATTAAGGAAACACAAGAAGTCGCACGAAGATGAAAGGCAAACCAAAAGATCAGTACCGTGTCCAGTATGCATGAAAGTGATGAAAAGCACCAAACAACTTTTGGCTCATATGGAAACACACGATGAAGGCCCCCATAATCCATTTCCATGCGAGACTTGCGGCAAAAGCTACAAGAATCTATTTTCCCTTAACATACACCTAAAATCTCATGGGAATGTTAGAGATTTTCAGTGTACTCTCTGTGACAAGGCTTTCACTAACGCCAGCCATTTGAGGCGGCACTCCAATTCGCATAcaggcGTTCGTCCATTTACCTGTGATATTTGTTCGAGGGGATTCCCATCGTCTCAAAACCTAAAAAGACATCTAATGACACATACTGGGGAAAAACCATACAGCTGTGATTCCTGCGACAAAAGTTTTCTTACGCTCGAAAATTTGAATAGGCATAAGAGGACTCACACAGGAGAAAAACCGTTTCCTTGTAATGTTTGCGGAAAATTTTTTGCCCACAGtaCCACTGCCAAAGAGCACATGAGAATCCACACAGGAGACAAACCTTTTGCCTGTAGTTTCTGCGACAGGCGATTTTCTCTTAACAAAGCCCTCTACAAACATATCCGCGAACGTCATCCCGATGATTTTCCGGAATTTAAACGCCAAAATGACCTTCCACCGAATATGAGAAGAGCGAGAGAAAAAATGAAACGAGAAACTTTATCGATCGAAGAAATAGAGATTAAACCCAGCTCGCTTAAAGAAACTGTCAAAGTGAAAGTCGAATCTAAAGTTATTTCTGCTCCTCCCAAAGTGAAAATTGAACCTGAAGATGATACAGGGTTGATAAGTGAACCTCCTGGTATTAATGTGAAGTTTGCTGGACTTCTTCAGGGAAAAGCCTCAAAGTCTTTTTCTATCAAAAAAGAGAAGCAAGACATTGGAGGGCCACTTCCCAAGGATTATTTTGACACTACCAAAGCACATATTCCAAAAGATGACCATTGTGAAACCATTCACATTGGTGTGGTCTGTTCCGGATACAATTCCAACTTAATGTTTCACACTTTActtaaatcgatatttttctaCAGAATAAACCCCCTGCATTTTCATATTCTTACGAACAAAGTTTCTGAAAAAATTCTTCAAGTCCTATTCGAAAGTTGGGATGTTCCACAAgTTAATGTTACTTTCTACGATTTGAATAAATACACGTCCGATGTAAGATGGATTCCGAATAGTCATTATTCAGGTATTTATGGGCTGTTAAAATTGGTCTTTCCAAAAATTATACCGCTTGAAGTTACTGATAGGATTCTTGTGCTTGACACTGACATGACTGTTGTGGcagatatttataaattgtggGCGATGTTCAGAAAATTCAACCGAAAACaggcgCTTGGAATGGTTGAAAACCAAAGCGACTATTATCTTGGAGACAAATCGTGGCCCGCTATCGGTAGAggttttaattcgGGCGTTTTAATGTACAATCTTTACTtgttaaaaaaactgaattggCCCAAATTGTGGTATGATACCGCTAAAAAAGCTACTCTGGATTATGGAACCACTCGACTGGCAGATCAAGATATTATTAACGCAGTTATCAAAGAACATCCGGAAATCATATTTGAAGTGCCTTGCGTTTGGAACACTCAACTGAGCGATCGAACATTAAGCGAAAGCtgttataaacatttcaaagtcaagataGTCCATTGGAATTCTCCGAAAAAGTACAACGTCGAAAATAAAGATGGTGAATATTTTCGAAGCCTTGCAGTCAGTTTTCAGGAATACAACGGAAATCTGTTGAGAAAAAAGTTGCAATTTTGTAACAATCGTCCATTATCTGCACCTCAAAATGTTTCTGATGACATCTGCTCCGAGTTCCACACGCTTTCGAGTAATCACTGGAggactattttatttttcagggaATATAAATACGTCGCCGTCGAAAATGATATTACATTTGTCGCACAGTTGTCTTATGATAGATTGCAGACTATTGAAGAGCTGGTCAAAGCTTGGCCCGgtcCAATGAGTTTTACTCTTTACGTGTCTGACCCGGAATTAATGAAAAGCATTACGTTTATTGGGAACTCGGAGGTTTTAAAAGACCGATGGAATGTCGCATACCATGCCGTTTTTAAAGAGGGggatttttatCCAATAAACATATTAAGAAATATCGGTCTAAGAAATGTGCTAACACAATTTGTCTTCTTAGCAGATATTGATTTTCTTCCTTCTAAAGATGTATACGAGACTTTAATAAAACACGTTACCGATTACGGGAGCTTAaagaataaagcGTTGGTAATTCCCGCATTTGAAGTTCAAAAATTTGTTAGTCAGTTACCAACTGATAGGAAACAACTTTTAAATGGTTTGAATGATAAATCAGTGATACCATTTTTGTCGATGATATGGGCCCCTGGCCATACTCCCACTATGTATAATGTTTGGACAAATAGCACAAAACCCTATAAGGTAAAATGGGAAGTCGATTATGAACCATACATTGTCGTTAGAAGTGACGTTGTAGAGTATGACGAAAAATTCATCGGGTTCGGTTGGAACAAAGTCTCTCATATAATGGAATTGGAAGCTCAGAACTATGAATTTATGGTTTTGCCAGATGTCTTTATCGTCCACAAACCTCATACCCCGAGTTACGATTTGGGAAGATTTAGAACATCGTCCGTATACAGGCTgtgTCTTCTTTTATTGAAAGAAGAATTCATAAAAAGACTCAACAAGCAGTATAATCGAAATTTTGCTTATCACAACACATCCGCAATGTTACCTTatttaagaagaagaaaaaggcAATATCAGAACTTGAATTTCGCTTCAACTACCATAGAAACGAACACTGATTACCCCAACGCCACTGAATAA
Protein Sequence: MAFNALQFLVKEEPKEADLNDQNVITNIGIKVKEEGDYLPDNPDLVDLGNTTNGILPQVWKEGCYKIDSSNTPTNETLSESTEGTKFNAQEWSNKYLTTLANSLNKTLIDASTSGGEINETDLSNSSELATRNLQHFMLDENSEDSTQDTNRTDSDQDWTEHKDGYFSCKICKVRFPDEFYLQNHFKYRRLGDKSYKCCSCDKIFRDNTQLNVHSRKHTGEKPYACTVCGKKFSVNGNLSKHMRIHTGERRFECFTCERKFTQFAHLEDHIKTHSGERPYICDFCNSAFKTKARLRKHKKSHEDERQTKRSVPCPVCMKVMKSTKQLLAHMETHDEGPHNPFPCETCGKSYKNLFSLNIHLKSHGNVRDFQCTLCDKAFTNASHLRRHSNSHTGVRPFTCDICSRGFPSSQNLKRHLMTHTGEKPYSCDSCDKSFLTLENLNRHKRTHTGEKPFPCNVCGKFFAHSTTAKEHMRIHTGDKPFACSFCDRRFSLNKALYKHIRERHPDDFPEFKRQNDLPPNMRRAREKMKRETLSIEEIEIKPSSLKETVKVKVESKVISAPPKVKIEPEDDTGLISEPPGINVKFAGLLQGKASKSFSIKKEKQDIGGPLPKDYFDTTKAHIPKDDHCETIHIGVVCSGYNSNLMFHTLLKSIFFYRINPLHFHILTNKVSEKILQVLFESWDVPQVNVTFYDLNKYTSDVRWIPNSHYSGIYGLLKLVFPKIIPLEVTDRILVLDTDMTVVADIYKLWAMFRKFNRKQALGMVENQSDYYLGDKSWPAIGRGFNSGVLMYNLYLLKKLNWPKLWYDTAKKATLDYGTTRLADQDIINAVIKEHPEIIFEVPCVWNTQLSDRTLSESCYKHFKVKIVHWNSPKKYNVENKDGEYFRSLAVSFQEYNGNLLRKKLQFCNNRPLSAPQNVSDDICSEFHTLSSNHWRTILFFREYKYVAVENDITFVAQLSYDRLQTIEELVKAWPGPMSFTLYVSDPELMKSITFIGNSEVLKDRWNVAYHAVFKEGDFYPINILRNIGLRNVLTQFVFLADIDFLPSKDVYETLIKHVTDYGSLKNKALVIPAFEVQKFVSQLPTDRKQLLNGLNDKSVIPFLSMIWAPGHTPTMYNVWTNSTKPYKVKWEVDYEPYIVVRSDVVEYDEKFIGFGWNKVSHIMELEAQNYEFMVLPDVFIVHKPHTPSYDLGRFRTSSVYRLCLLLLKEEFIKRLNKQYNRNFAYHNTSAMLPYLRRRKRQYQNLNFASTTIETNTDYPNATE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00387451;
90% Identity: -
80% Identity: -