Basic Information

Gene Symbol
-
Assembly
GCA_947507615.1
Location
OX382324.1:17344738-17349626[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.016 1.2 10.3 1.4 1 23 159 181 159 181 0.96
2 9 7.5e-05 0.0058 17.6 1.0 2 23 189 211 188 211 0.93
3 9 3.2e-06 0.00025 21.9 3.1 2 23 220 241 219 241 0.96
4 9 3.2e-06 0.00025 22.0 0.1 2 23 250 271 249 271 0.96
5 9 0.00091 0.071 14.2 5.1 1 23 279 302 279 302 0.97
6 9 2.2e-06 0.00017 22.4 0.5 1 23 307 329 307 329 0.98
7 9 2.7e-05 0.0021 19.0 4.5 1 23 335 357 335 357 0.98
8 9 9.7e-06 0.00076 20.4 0.3 1 23 363 385 363 385 0.98
9 9 2.4e-05 0.0019 19.2 2.0 1 23 391 413 391 413 0.98

Sequence Information

Coding Sequence
ATGAATCAGCTGTGTAGAGCATGCTTGGTTGCGAAGGAATCCTTTGAATACACGATATATGAGAACTTATCCGCCGATGTTTATTCCTTCTGTACTTCAGTGGAGGTTCGTAAAGATGATGAACTGCCAAAAACTGTGTGTAACACTTGTTACGAACTACTTAAGAAGTACTCCGACTTCAAGAAGGCGTGTATTCAAGCACAGAACACACTGGTGTTCCAGAATAATATAAAAGTTTCAGAGAATGTTGCTTTTAAGTGTGAGGTGGATAACAGTTGCGAAGTGCTTGTTGATGAGGTTAATGACCTCCAGGATCATGGAAATTCTAGTAGTAATGAAGATGCATTAGTTGCAGAAGAAATAAGTGAAAATATCCTTTATAAAAATGAAAAGAAAATTAGTCCTAAGAGAAAAGCACAAGTAAAAATGAAAAAAGGAATAAAACATGTGAAGAAAAAAGCAAAAGTGTTTGGATATGTTTGTGAAATATGCAAAAGCAAGTTCAAATACAAGGAGAGATATGAAGTACATAAATTGGAACACCAGGGGCAAACAGTAAACAAATCATGTGCAACATGCAAGAAAACCTTCATGACCTGGAGTGGGCTACAGCGGCACACAGATAGTGAGCACAAAGTGGTCAAGATGAACACCCTCAGATGCAAGGAATGCGGGAAAGTGTTTAAGAACAAACACACTCTCAAACTGCACGCCAAGCTGCATTCTACGCTTGAAGTTAATCTGAGCGTTTGTGATATTTGTGGGAAGAGTTTCGCTAGTCCTGTTACTTTAAAACTTCACCTAGAAAGCCACAACGAGAACCGAGCAAGAGACTTCCCCTGTGAGCACTGCGGCAAGAAATTCTTCACAAAATACATCCTCCACTCACACATCAAACGTCTACACACCGGCCAACGATACATCTGCCAACTGTGCGAGTACCCCTTCACAGACAAGTACAATCTGGGCAAACATATGCTCACACATCAAGGCATAAAGGAACACAAATGCGACATATGTGAGAAATTCTTTTCCACTCATTCAACTCTTGTCATTCATAAAAGGATTCATTCAGGGGAGAGGCCGTTTCCTTGTGGTTATTGTGCAAAAGCGTTTAGTTCTAAGAATAGGCTGATTGTCCATTTAAGGACTCACACTGGTGAAAGGCCGCATAGATGTGTGGTTTGCAATTTGGCGTTCACACAACTTGGCACTATGAAAAGACACATGAAAACACATAATAAAGCTCCTGCTATTGGACTGTAA
Protein Sequence
MNQLCRACLVAKESFEYTIYENLSADVYSFCTSVEVRKDDELPKTVCNTCYELLKKYSDFKKACIQAQNTLVFQNNIKVSENVAFKCEVDNSCEVLVDEVNDLQDHGNSSSNEDALVAEEISENILYKNEKKISPKRKAQVKMKKGIKHVKKKAKVFGYVCEICKSKFKYKERYEVHKLEHQGQTVNKSCATCKKTFMTWSGLQRHTDSEHKVVKMNTLRCKECGKVFKNKHTLKLHAKLHSTLEVNLSVCDICGKSFASPVTLKLHLESHNENRARDFPCEHCGKKFFTKYILHSHIKRLHTGQRYICQLCEYPFTDKYNLGKHMLTHQGIKEHKCDICEKFFSTHSTLVIHKRIHSGERPFPCGYCAKAFSSKNRLIVHLRTHTGERPHRCVVCNLAFTQLGTMKRHMKTHNKAPAIGL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-