Basic Information

Gene Symbol
-
Assembly
GCA_947063395.1
Location
OX346736.1:6168257-6170865[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.19 15 7.0 0.2 2 23 50 72 49 72 0.94
2 18 1.1 92 4.5 0.1 3 23 100 120 98 120 0.93
3 18 0.00061 0.049 14.8 0.2 1 23 124 147 124 147 0.97
4 18 0.27 22 6.4 0.3 2 21 152 171 151 172 0.92
5 18 0.2 16 6.9 7.2 1 23 179 202 179 202 0.94
6 18 0.001 0.081 14.1 1.1 1 23 209 232 209 232 0.94
7 18 0.015 1.2 10.4 0.5 3 23 297 318 296 318 0.97
8 18 0.52 42 5.6 0.1 2 23 343 365 342 365 0.94
9 18 0.11 9.2 7.6 0.1 2 23 389 410 388 410 0.96
10 18 0.00019 0.015 16.4 0.7 1 21 414 434 414 435 0.96
11 18 0.047 3.8 8.8 0.2 1 23 476 499 476 499 0.97
12 18 0.36 29 6.1 1.7 2 23 525 547 524 548 0.95
13 18 0.003 0.24 12.6 0.4 2 23 571 592 570 592 0.94
14 18 0.0035 0.28 12.4 0.0 1 23 596 619 596 619 0.97
15 18 0.17 14 7.1 0.5 1 23 623 646 623 646 0.97
16 18 4.5 3.6e+02 2.6 0.3 1 23 651 676 651 676 0.87
17 18 0.00016 0.013 16.6 3.0 1 23 685 708 685 708 0.97
18 18 0.0001 0.0083 17.2 0.5 1 23 718 741 718 741 0.97

Sequence Information

Coding Sequence
ATGTGCGTCTATTGCTGCGACGAATTCGAAGAACCAGAAGGATTCCGGGCGCATGTGGACGAAAACCACGAGAAGGTTAATCTATTCACGGCGTTCGCGCACACCGGCCGGAATAAAGATTATCTCAAAGTAGACTGCATCGATATGAAGTGCAGGATCTGTAGTAAACCTGCCGAGTCTTTACAGGAGCTAGCTACTCATCTGAAAGACACACATTTCACAGAGGAAATTGATAAGCTAGACCTAAAGTATGATATAGCTCTGCATCCTTACAAGCTGTATAAGGATAGATGGGACTGCGTCAATTGCAACGTGAGGATGCCAAGTCTTGTCAAATTAGTTCGACACATGTCGTCACACTACAAGGAGTTCACGTGCGATTCATGCGGACGAGGCTACATATCTGTAGACAGCTTGAACTATCACATTAGGCTTAGCCATTCGGGGAAAATATCATGCAGAAAGTGTTGGAAGGAGTTCCCAACCACACAAGAGAGGAAGGAGCATCTAAAGGTTTCAGCGAAATGTCGACCATTCCGATGCTTACATTGCAACGAGACATTCTATTCATGGGAGTATAAGCATAAACATCAGATTGCTTGCCATGATGACCAGGCTATGACATATCGTTGTCCGGAATGTGATGTTGTGTTCCAAACGCGAAAGAGTTTCTACAATCATTTTAATTTAGAACACTCGCAATCTGCGTTCACTTGCACTTGTTGTAATAGAACGTTTGggGCCGTATTGGAAATACGCGGACATTGTGAGAGTGAACCAAAAAAGAAAATTGTTCTTGTGTGCCAGTCGGCACAGCGGCGCAATGCCGAACTCATTCTTAAATATTCTACAGCCTATCCGTTCAAAACGCGTTTTAGTCAAATTCTATGCGCTTTTTGTCACGAAGAATATAATACATTGCCAGACCTGAGATATCACATGAAAATTGAACACGTTAATTCTgactttaaaaatgttttctatAGAAATAGCGATAATTTGATTAAAGTAGACATATCGGAGATGAAATGTAAAATTTGCTCTCTAGTCATACCCGATATTGATACTTTGATGACACATTTTTCAAGGGAACATCAGAAACGCGTTAATTTCAAGGAGCGCTTTGGTGTATTACCTTACAAACAAAACGAAGAGAACCAATGGATGTGTGTGTATTGCCAGCGTGTGGTGGTAGAATTCGTTGCATTCAAACGCCACATTGTGACACACTTCATGCAGTATACGTGCGATAAGTGTGGCACAAGTTTCGTGTCAGACTACGCGTTGCGCGATCACCACCGTCAGGTAAAGTGTTTCAGGACAGAGTACCATCCTCGCAACGGCAAGATCATGAACTCCCGGAGTAATGCCGAAATCATTCTTCAATGTTCCACCGCTTGTCCGTTCCGAACGTGGAAGAATAATTTCAGTTGCGTGTTCTGTCGTCTCCAATCAAACGATCCTACCGCGTTGAGAATCCATATGGCCACGCGTCACACCAACTTTGACGTGCAGGCGGCTTTCTATAAGAAATTAGGTAAAGATTTTCTTAGTATCGATGTAACCGACTTACAATGCAAGCTTTGTTTTATGTCTATTCCGACTTTTGATACTTTGACTTATCATTTAAAGAACGATCACCATCAGCCGATAGACTTGGATGCGCAATTAGGCGTCCTACCTTTTAGATTGAACGATGGATCCATTTGGAAATGCACAATATGTCCGAACGAATTCAAAGACTTCATATCGTTAAAGAAGCACACAGCTGAACATTTTCAGAATTACGTGTGTGATGCTTGCGGGGAAGGATTCATAACGGAATCTGCGATGGTAGCACATACAAAGATACCCCACGAGAACAAGTACAGCTGTAGTCGATGTATCGCTACATTCTCAACGCTGGACGAGAGAAACGTCCATGTCAAAACTCAACACACGTCAACACCATACATGTGTGTGTATTGCACGGATAAACCACGTTTTGCCAACTGGGAATTGCGGAAGAAGCATCTGATGGAAGTACACAATTATAAAACTGGTCCCGATAAATACGAGTGTACTACCTGTCAGAAGACGTTCAAGACTAGATCGGGGAAATTCAACCACATGGCGAGAACTCATAGAATGAAAAGAGACTCTGAACTTAACTACCCCTGTCCGAGTTGTCCCAAAGCCTTTACAACTAAATTGTTCCTAGATAAACATATGGCTAAGAAGCATTTTGATTCGTAA
Protein Sequence
MCVYCCDEFEEPEGFRAHVDENHEKVNLFTAFAHTGRNKDYLKVDCIDMKCRICSKPAESLQELATHLKDTHFTEEIDKLDLKYDIALHPYKLYKDRWDCVNCNVRMPSLVKLVRHMSSHYKEFTCDSCGRGYISVDSLNYHIRLSHSGKISCRKCWKEFPTTQERKEHLKVSAKCRPFRCLHCNETFYSWEYKHKHQIACHDDQAMTYRCPECDVVFQTRKSFYNHFNLEHSQSAFTCTCCNRTFGAVLEIRGHCESEPKKKIVLVCQSAQRRNAELILKYSTAYPFKTRFSQILCAFCHEEYNTLPDLRYHMKIEHVNSDFKNVFYRNSDNLIKVDISEMKCKICSLVIPDIDTLMTHFSREHQKRVNFKERFGVLPYKQNEENQWMCVYCQRVVVEFVAFKRHIVTHFMQYTCDKCGTSFVSDYALRDHHRQVKCFRTEYHPRNGKIMNSRSNAEIILQCSTACPFRTWKNNFSCVFCRLQSNDPTALRIHMATRHTNFDVQAAFYKKLGKDFLSIDVTDLQCKLCFMSIPTFDTLTYHLKNDHHQPIDLDAQLGVLPFRLNDGSIWKCTICPNEFKDFISLKKHTAEHFQNYVCDACGEGFITESAMVAHTKIPHENKYSCSRCIATFSTLDERNVHVKTQHTSTPYMCVYCTDKPRFANWELRKKHLMEVHNYKTGPDKYECTTCQKTFKTRSGKFNHMARTHRMKRDSELNYPCPSCPKAFTTKLFLDKHMAKKHFDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-