Basic Information

Gene Symbol
topi
Assembly
GCA_947063395.1
Location
OX346711.1:12775436-12777592[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0078 0.63 11.3 0.4 1 20 132 151 132 152 0.96
2 9 0.014 1.1 10.5 8.1 1 23 173 195 173 195 0.98
3 9 2.6e-05 0.0021 19.1 0.5 5 23 204 222 203 222 0.97
4 9 1.5e-06 0.00012 23.0 3.6 1 23 228 250 228 250 0.98
5 9 4.8e-05 0.0039 18.2 3.2 1 23 255 277 255 277 0.98
6 9 1.5e-05 0.0012 19.8 0.3 1 23 283 305 283 305 0.98
7 9 0.012 0.93 10.8 3.5 2 23 312 333 311 333 0.97
8 9 1.4e-07 1.1e-05 26.2 2.5 1 23 339 361 339 361 0.99
9 9 8e-06 0.00065 20.7 1.6 1 23 367 390 367 390 0.97

Sequence Information

Coding Sequence
atggcTAGTTTACTGCTAGGTCTCGACTTAAACCTGAAAAACATTTGCAGAATTTGCTTACGAGATGGTACAGAATCCACAGACTTGTTCTCCGATGATGCTGAATCGATTCAGATTTTAAATAAGATTTCAGTGTGTTTTCAGTTAATTCTTAATTCAGATAAATACTTACCTTGTGTTATTTGCCAGGAATGTATCGAAGATTTAAATAAAGCGTATAACTTCAGAGCAAAATGCGTAACAATCAATGAACGTTTCAAAGATTACTGTGAGAAGTTACTGAACTCTGAAGAATCAGTGAAATCCGACACGAATTTCGAGTTCTTGGATGATAATCAGTCTGTCTCCAACGATAACCTTTACTGTGAACCTCAGGCAGACAAAAAAACTGTTTTCAAATGTGATCTATGCCATAAAGAGCTGAAATCAATGGAGTCTCTACTAAAACATGTTGTGTGTATGCATGAGAAGAGGCGGCATGTCGGCCGCGTCACAGGGTACGGCTCTACAAGGCGCTATCATTGCACTACTTGTTCATATTGCACTCCACATAGTCAGACTCTAGTCAATCATATGAGGAGACATAATGGAGAGAGACCTTTTGCTTGTGAGTGTGGCAAAAACTTTACACAGGCATCAAGCTTAGCAGCACATCGCAAAACTCACAGCCCTACAACATATTTTACTTGTTCATCATGTGGGAAACAATTCAAACATGCCTACTCACTCAAGAATCACCTCCGTGTTCATGAAAATGGGAAATTCAGCTGTAGTATTTGTTCAAAAGTTTTGAAATCAAAGGACACCTTACATTTGCATATGAAGAGACATTACAAACTGTATAACTACAACTGTGAAGACTGTGGTGACACATTTGTTACACAGGCAGAGTTGAAGAATCATAGATTGAAACATACGGGTGAAAAGAAACTTGAGTGTCATATTTGCAGTTATAAGACCAACCTGAAGAAGAGTCTCAATATGCATCTTAAGAGACATGTAGGTGACAGATCATTCAAATGCAATTTCTGCAACAAAGCATTCTACACACGTGATGACTTGAGGCGACATTTGCGAGTCCACACAAAAGAAAAGCCCTTCTCTTGCCAGACTTGCGCACAAAGGTTCACCTACAGTTCCAGTCTTAACAAACACATGCTAACAGTTCATGGCATTCAATTCAAATGGGGTGATACTAAATTGAAGGAAAGAAGAACACAGAAATATTCTTTGAAAATAGcttcataa
Protein Sequence
MASLLLGLDLNLKNICRICLRDGTESTDLFSDDAESIQILNKISVCFQLILNSDKYLPCVICQECIEDLNKAYNFRAKCVTINERFKDYCEKLLNSEESVKSDTNFEFLDDNQSVSNDNLYCEPQADKKTVFKCDLCHKELKSMESLLKHVVCMHEKRRHVGRVTGYGSTRRYHCTTCSYCTPHSQTLVNHMRRHNGERPFACECGKNFTQASSLAAHRKTHSPTTYFTCSSCGKQFKHAYSLKNHLRVHENGKFSCSICSKVLKSKDTLHLHMKRHYKLYNYNCEDCGDTFVTQAELKNHRLKHTGEKKLECHICSYKTNLKKSLNMHLKRHVGDRSFKCNFCNKAFYTRDDLRRHLRVHTKEKPFSCQTCAQRFTYSSSLNKHMLTVHGIQFKWGDTKLKERRTQKYSLKIAS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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