Basic Information

Gene Symbol
PLAGL1
Assembly
GCA_958496145.1
Location
OY292350.1:2394467-2408449[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 29 0.39 25 5.9 1.9 2 23 12 33 11 33 0.97
2 29 0.0048 0.31 11.9 0.0 1 23 37 59 37 59 0.96
3 29 0.00051 0.033 15.0 1.7 1 23 64 87 64 87 0.97
4 29 0.37 24 6.0 0.5 1 23 94 117 94 117 0.83
5 29 0.00015 0.0095 16.7 0.3 2 23 125 147 124 147 0.96
6 29 0.00067 0.044 14.6 4.5 1 23 153 175 153 175 0.98
7 29 2 1.3e+02 3.7 0.3 1 13 181 193 181 195 0.88
8 29 0.14 9.5 7.3 4.4 1 23 264 287 264 287 0.91
9 29 0.18 12 7.0 0.1 2 23 316 338 315 338 0.94
10 29 6e-05 0.0039 17.9 0.4 1 23 386 408 386 408 0.98
11 29 0.021 1.4 9.9 0.7 1 23 413 436 413 436 0.94
12 29 5.1 3.3e+02 2.4 1.9 2 23 444 466 444 466 0.87
13 29 0.00017 0.011 16.5 3.3 1 23 473 496 473 496 0.98
14 29 0.0042 0.27 12.1 6.0 1 23 502 524 502 524 0.98
15 29 2.1e-05 0.0014 19.4 0.1 1 23 530 552 530 552 0.98
16 29 0.031 2 9.4 0.4 1 14 558 571 558 572 0.92
17 29 0.0026 0.17 12.8 3.8 1 23 643 666 643 666 0.96
18 29 0.72 47 5.1 0.1 2 23 694 716 693 716 0.94
19 29 0.056 3.6 8.6 1.7 1 23 809 832 809 832 0.93
20 29 0.28 18 6.4 0.2 3 23 930 951 928 951 0.91
21 29 0.41 27 5.9 0.1 2 23 977 999 976 999 0.94
22 29 0.015 0.99 10.4 0.1 2 23 1022 1043 1021 1043 0.97
23 29 0.85 55 4.9 0.1 1 23 1047 1069 1047 1069 0.84
24 29 0.00022 0.014 16.1 1.7 1 23 1074 1097 1074 1097 0.97
25 29 0.95 62 4.7 0.8 2 23 1105 1127 1104 1127 0.94
26 29 0.00033 0.022 15.6 1.7 2 23 1135 1157 1134 1157 0.96
27 29 8.4e-05 0.0055 17.5 2.5 1 23 1163 1185 1163 1185 0.98
28 29 5.5e-05 0.0036 18.0 0.6 1 23 1191 1213 1191 1213 0.99
29 29 0.00039 0.026 15.4 3.5 1 23 1219 1242 1219 1242 0.96

Sequence Information

Coding Sequence
ATGGTGCCCTTCAAATTCGACACTGATAGCATCCGTTGCTGTATTTGCTCTAGCGTTTTCGGGAAATTTCGAAGATTACAGGAGCATATGAATGTGCACTACAGGAATTTCGTGTGTGACGTATGCGATGTAGGTTATGTGACCCAGATATCCTTGTGGCGTCACTCGGCTAAACACAAGGGGGACACATTTAAATGTAGCTTTTGTCCCAAAACATATGATACTCAGCGAACGATGAAAGCGCATGAAAGATATGCACATACTGATAACTATTTATCGCATATATGTGGGTACTGTAATGAACGATTCGCGACCAATATGCGAAAGAATGAGCATTTGGCTGAAGTCCACGACGTGAAATTTCATGCACTCAAATGTACTGCTTGTGATAAAAGTTTCCCTAACAAACCAGCTTTAACTATACACACTAAGAGAGATCACTTAATGGAACGAAAACATAAGTGCGATCAATGCGAGATGGCTTTCTTCTCACTACATGAGCTGACGAAACATATGATGAAGCATACGGGGGAAAAGAATTTTCAGTGTGATATCTGCTTGAAGACGTACGGACGTAACAAGGGAAAAGGGGACGTCGAAACTGAACTGGAAAATTTTGATGCAGCTGTTTTAGTTATTGTAGAAGGTGTTAAAGCGGGGAAAGATATCAAGGTAATGGATAAACCAAAGGCTATAGCTCGAGGACTACTAGAAAAACATCAGCATAACCTTAAAGTTATCTTACAATCTTCGAATGCTACTCCCATACTACGTTTGGGAGGTGTGGGGTACATGTGCAGCCACTGCTGCAAGGAATTCCCAGACCCTAAGGACCTAAAGGAACATTATTTCGAGTTTCATCCATGTGAACTAATCCCTGCTTTTGGGTACACGCGATCAACCCCTCTGTCGGAGTACTGCATAAAATTAGATATTACGAACCTATCCTGTAATATATGCGAGACAGATATCGACTCTCTAGATGATTTGACCACCCATCTACAAGAGGAACATGACGAATTCATACACACAGATATCCCGAGCCATATAATGCCTTTCAAATTTGATACGGAAGAACTGAGATGTTGCCTTTGTTCCGAGCCCTTCTACaagttcaaaatattgttagaGCATATGCATAAACATTTTAGGAATTACGTGTGTGAAATTTGCGACGCTGGCTTCATAAATAAGGGCTGTTTGACCCGTCACGGGAACACACACATGAAGGGGGTGTTCCCATGCGAGTTTTGTTCCAAAGTCTTCGACACGAATATGAAGAAACGGGCTCATGAAAGAGCCAACCATACTAACTCGAAGAGTCTGAACAGATGTGGTTATTGCAACGCAGGTTTTAAAGAACACCATTTAAAAGAGCAACATTTGTATGAAGTCCACGGTGTCACCAGAAAGGACTACAGATGCCATGCTTGTGATAGAAGTTTTGATACCAAACGTAAATTGAGGGTCCATGTTAAAAGAGATCATTTGTTAGAACGAAAACACAAATGTCAGCATTGTGATATGGGCTTTTTTACTGCACACGATGTTAAAAAGCATATGGTGACTCATACTGGGGAAAAGCAATTTGAATGTCCCGTGTGCTTGAAGGCTTATGGAAGAAAGTCTACTCTGAATGGACATATGAGGATCCATAACGATGATAGAAGATTTAAATGCGAACATTGTGGAATGGCTTTCGTTCAGAAATatgaagaagaagaaaaagtggCAAGACCAGCTAAAATCAAACAAGAACCAAACACTGAAGATCTAGAATCTAACAACGAAGATTTCACAGAAATAAGCATAGAGAAGGCACCACAAAAGCGTATCAAACGGCTTCTTTACAAGCATCTAAATAATCTGAAGATCATTCTCGAATGTACGAACGCAACAATGATTCTTCGACATGGAGATAAAGGATACTGCTGTTGCTATTGTAATGAAGCATTTGAAGATCCAACACAGTTAAAAGAACATACTTTAAGATCTCATGCCAACGAGGAGatattttatggaaaaatACCAGCGAGAGGTCCCTCAAGATTCTTAGTCAAATTAGACATCACTGATCTAAAATGCACGCTCTGCGATGAAGATTTAGAATCACTAGAAAACATTTTCGTACatctaaaagaaaaacacgATAAGAAGTTCCATACGGATATAAAAGATCAAATATTTCCATTCAAATTTAATACTAAGCAATTCACTTGCTgtgaACCAAATGAAAAAGTCAAGGGTAATGAACACAACGATACAGATCCATCGGATACAGAAAGTATACCTGAAAACGATTTGTTAAATGAAAGAGATTACAAAACGGCATCAAGAACCGATTTGAGGAAACATAGGaacaatattaaagaaattctaCTGAACTCTAACGCTACACCAATTCGGCGGCACGTAGGCGTTGGATACACTTGCTGTTATTGCGAAGACCAGTTTATAAAACCAGCCGATCTAAAAAGACACACTCTAGACACTCACAAGAAAATAACAGAAGCCAATTTTATGAAAAGCATGAACTTATCCGAATATGTCGTCAAGGTAGATATAACCGGATTAAGATGTCGCGAGACGGGAACTAGAATAATCAAAATAGAAAAACCGACAAAACCAACCGTTGAATTGAAGTTCTACTCGAAATTATCTACGAGGGACCCGAGTTTAGCTCACGGATCCGCCTCAGAGACTATGAAGAATAGAATCAATCTCAGATATATATTGCTTAACTCTAACGCGAACCCCATACGGTGTAAAGATGGGAATGGGTACGGCTGTTCATTTTGCCCAAAACAGTTGCAAGACCCGACCGCATTGAAGAAACACTTTCTAGAAGAACACAACAACGACAAAGTCATAAAATACATGTCCGCGAAACTATTTCAACACGTCATCAAACTAGATATAACGTTCTTAAACTGCGCTCTTTGCGATGAAGATTATCAACAGCTAGACGATTTTGttgtacatttaaaaaatgtgcaTAGCAAACCTATGTATTTAGATGTTAAAAGTCAAATAGTCCCCTTTAGGTTCGACTCGCCTTCCCTCAAGTGTGTGATATGCGCAGCAGAATTCGTTTCTTTTAAACTCTTACAGGAACACATGAACTCCCATTTCAGGAACTATGTTTGTGAAATTTGCGGCGCAGGGTTTGTTATTGAAAGACTTAAAGGCAACCACGTCAAAAGGCATAAAAGCGGCGAGTATAAATGCGATCAATGCGACAAAACATTTACTAATCCAATGCGCATGCGTGAGCATGAGAAAAGATCACATCTCGGTTTAGGCGCGAGAAATAAATGCTCTTTTTGCTCCGAAAGATTCATTGATTACTGGAAGAAGATGGATCATATGGTGAAAGAGCACGGAATGCCTCCAGTTGTGTTGAAATGTTCGGCTTGCGATCGGACTTTTAGGACTCAAAGATCGTTGTCGATACACACGAAGAAAGATCACTTATTGGAGCGAAGACACAAGTGCAGTGAGTGCGATATGAGATTCTTCGGGAAGAGTGGTTTGCAAAAACACATGGCGAAGCATACAGGGTTAAGGCAGTTCAGATGTGATGTCTGTTTGAAGGCGTATGGGAGGAAGAACACGCTGAGGGAACATATGAGAATTCACGCTAATGATAGAAGATTTGCTTGCGTACATTGCGGTCAGGCGTTCGTTCAAAAGTGTAGCTGGAGGAGCCATATGCGATCTAAGCATGGCGAAGAAGCTTAA
Protein Sequence
MVPFKFDTDSIRCCICSSVFGKFRRLQEHMNVHYRNFVCDVCDVGYVTQISLWRHSAKHKGDTFKCSFCPKTYDTQRTMKAHERYAHTDNYLSHICGYCNERFATNMRKNEHLAEVHDVKFHALKCTACDKSFPNKPALTIHTKRDHLMERKHKCDQCEMAFFSLHELTKHMMKHTGEKNFQCDICLKTYGRNKGKGDVETELENFDAAVLVIVEGVKAGKDIKVMDKPKAIARGLLEKHQHNLKVILQSSNATPILRLGGVGYMCSHCCKEFPDPKDLKEHYFEFHPCELIPAFGYTRSTPLSEYCIKLDITNLSCNICETDIDSLDDLTTHLQEEHDEFIHTDIPSHIMPFKFDTEELRCCLCSEPFYKFKILLEHMHKHFRNYVCEICDAGFINKGCLTRHGNTHMKGVFPCEFCSKVFDTNMKKRAHERANHTNSKSLNRCGYCNAGFKEHHLKEQHLYEVHGVTRKDYRCHACDRSFDTKRKLRVHVKRDHLLERKHKCQHCDMGFFTAHDVKKHMVTHTGEKQFECPVCLKAYGRKSTLNGHMRIHNDDRRFKCEHCGMAFVQKYEEEEKVARPAKIKQEPNTEDLESNNEDFTEISIEKAPQKRIKRLLYKHLNNLKIILECTNATMILRHGDKGYCCCYCNEAFEDPTQLKEHTLRSHANEEIFYGKIPARGPSRFLVKLDITDLKCTLCDEDLESLENIFVHLKEKHDKKFHTDIKDQIFPFKFNTKQFTCCEPNEKVKGNEHNDTDPSDTESIPENDLLNERDYKTASRTDLRKHRNNIKEILLNSNATPIRRHVGVGYTCCYCEDQFIKPADLKRHTLDTHKKITEANFMKSMNLSEYVVKVDITGLRCRETGTRIIKIEKPTKPTVELKFYSKLSTRDPSLAHGSASETMKNRINLRYILLNSNANPIRCKDGNGYGCSFCPKQLQDPTALKKHFLEEHNNDKVIKYMSAKLFQHVIKLDITFLNCALCDEDYQQLDDFVVHLKNVHSKPMYLDVKSQIVPFRFDSPSLKCVICAAEFVSFKLLQEHMNSHFRNYVCEICGAGFVIERLKGNHVKRHKSGEYKCDQCDKTFTNPMRMREHEKRSHLGLGARNKCSFCSERFIDYWKKMDHMVKEHGMPPVVLKCSACDRTFRTQRSLSIHTKKDHLLERRHKCSECDMRFFGKSGLQKHMAKHTGLRQFRCDVCLKAYGRKNTLREHMRIHANDRRFACVHCGQAFVQKCSWRSHMRSKHGEEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-