Basic Information

Gene Symbol
-
Assembly
GCA_002150865.1
Location
KZ117247.1:29093-43018[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.41 29 5.5 0.4 1 23 209 231 209 231 0.94
2 13 2.4 1.7e+02 3.0 0.2 3 15 269 280 268 283 0.78
3 13 0.82 58 4.5 1.8 5 19 294 308 288 311 0.87
4 13 0.013 0.91 10.2 0.7 1 23 324 347 324 347 0.95
5 13 0.00063 0.044 14.3 0.3 2 21 385 404 384 405 0.92
6 13 0.036 2.5 8.8 2.9 2 23 777 798 776 798 0.93
7 13 4.1 2.9e+02 2.3 2.5 3 23 883 903 882 903 0.91
8 13 0.00062 0.044 14.3 0.3 2 23 919 940 918 940 0.97
9 13 4.1e-07 2.9e-05 24.3 2.7 1 23 946 968 946 968 0.99
10 13 0.00027 0.019 15.5 0.1 3 23 975 995 973 995 0.95
11 13 0.00038 0.027 15.0 0.6 3 23 1003 1024 1001 1024 0.94
12 13 0.12 8.5 7.1 0.1 1 20 1031 1050 1031 1051 0.94
13 13 0.00033 0.023 15.2 0.5 3 23 1063 1084 1062 1084 0.95

Sequence Information

Coding Sequence
ATGGCTGAAGCATCGAGGAAAAGATCTAGGAAGTCTAAAATAGTGCTGAGGGATGTCGCATTGGATGATGAAGACGATATTGAGTTGCAGttgccaacaaaatcaaaaaaagttataataaaaaaggaacCTAAAAAGGAAAGTGCAGCAAAGAAACCTGCACGAAAAACTACGAAAATAAACCAAGCCGTGGACAAAAGTGTGCTTGATAAGATAAAAGCACCAATTGAGACAAATATTGAGGAACCAACACCTAGATTTGACATCAACGTTGAGATAGAGGTCGAAACATGTGATGACGAAAATTTTGACACCAATGACGAAAACTATGACCAATCAACAGAGCAAATAAAAGATGTGGAAGAatcttcaaacaaaataaaaattaaaaaggaaataaagaaTGTAATATTGTCACGAGAAACTGTCATTAGGGAgtcgaataaaattaaagaaacatcAACAAATCTAGCTGATTCTATACTAGATATTTGTCTAAGAAACTCTTTAGGTTTCTTTGAAGAACAACATCTCAGTACATGGTATGACATTCAAATTAAGCACGTGTTGACATCCTGGGAAGACTGGCAGTCAAAAAGTTTTCACCGAGAACATCCTCTTTTCTACAAATGTTATATTTGTACCAAATCCTGGTGGAATCTGTCAGAATTCCGTGACCACATACTTGAACATACCACGGTGAAGCTAGACATTGAGAAATATACACAGCATGAGTGTAATATTATAGCTTTTAAACCAAACAAAAGGCCGGATGAAATCAAAGAATTTTTTACCGAAGGCCTATGTTACCATTGTGGTAAAGATTACTCAAAACATCAATTATCAGCCCGAGATGACAAAAATTGTTACATGAACACCGATTGTTTAAAACGGTTCCCTACGTGCACAGAGTTAAAACACCATGCGTACGCTTGTAAAGTCTGCAGCATTAAAAATAACGAGTACAGCTTCTGTTGTCAAATTTGTACGTTAAGTTTTGGTAAGATTGATGATTTGACTGGTCATATGCTTTTAATGCATTCAGTGAAGTCCGATAGGCCTATTGCTGCAAACTATTCCAAGTGTAAAGATTGTTCTGAAGTTCATTCGTCAAGTATGATTCATACATGTGGTAATAAGGAAGCTAACACAATGTGTCCGTACTGTTTCAAAAGCTTTTCGAACAAATCCTTAATTTTGGACCATATCAGTCGGTCAACCGTACCTTGGCATTGTAAAATTTGCAGTGAAGAAGTTAAATGGAGTTGTACGATACACGAGCATTTATTAACACATACTGATAAATatatgtttgtgaaaatatgcgTAAAATGCGAAGGGATTCATGTTTTCCTTGATGATCGGGAGGCAAAACTACATATGATGGAAAAACATGGATATAATGATTTTGATAGAAATTTTCTTAAAattcCAGTACCAGTTTCCTGCATTTACTCTGATGAAGAGAAATGTGAACAAGAAGAAACTCTACAAGATAAATTATTACCTGAATTTTCACAAACACAAAATGTAGGAGTGTTTATACCCAACCCAGAATCGGTATTTCGTCGAGTTTCAATACTAAAAAGGTCACATAAGCAGCAAAAAATCGTTTTGAAGCCGCAAGAAtcgattttgaaattaaaatctttgtcGGACCATTCTGAAAGTGTCGATTCAAAAGCTAATATATTGATACCAGCTTTAAATGAACAAAATTCGGTTTTTGAAAAGCAAGAAAACGCTACTGAAAATGTGATGGACATAGTAAAAGTAAAAGAGGAACCTATAGATTCAGATGATAGTTCAAACTTGGTAATTAAAGAGGAACCGATGGACTTCGATTACGATGATTACGCAATACAAGACAATACAACGAATACAATACAAGAAAGTGCACATGCAGACTATGAcgaagatattgtaaaaagtgaAAATTCAGAATATGAAGATGATATtatcaaattaaacataaacatcGAAGATATACTTGCTAAACAAGAATCCAGTCGAGTCTTTGCGTTTGAACCggattcaaaaataaaatccgaGCCAGCAATTGACACTAATATAGAAGTCGATAAAGATTCAATTTTAGAACCGGAAGTAATCATATCGCAAGAAGGTGAAGAAAGAAAGAGGTTGTATGGTTGCTCCAAATGTCCGTTCAAAGGGAAACAAGAGAATTATTTAAGACACATAACACTAGACTGCCTGTATTCCACCGTTGGTAACCGCAAAAAGTTTATATGCGTTCGAACCGGCCAGTTCTATAAAACGATCAAAAAGTACTTACTACATTTTTTAGAACATGGATACGAACCTCTTTGCTGTCCTGATTGCTCAAAACAGTTTCACACATACAGTAAATTAGGGTCACATGTACTCGGCCAtgtcaaacaaaattttgtacGGATTAAGAAAATCAGTGAACGGTTGGTTGCTGATGCTAaacctgagtaccagtgtaggAAATGCTTGAAGATTGTTATTCTACAAGAGTACTTTCAACACTGGGAGTCTCATATTTGTGATGCGAACGTTCCGGAGAAGAAAGAAGTGGTGGCCGCACCAAGATTGGTTACGGATATGTCTGAAACGGCTATTCAAGAATGTATTAAAACGTTGCAGCGGAAACCAAAAGACTGTGTCTACTGCAAACGCCGGTTCCAACGAGTCAACGAGTGCAAAAGACATGTTATAGAACACCTCTTAATGGACGCCTACACGCAGAAACAAATCTTAGGCCTTCTCAAATGCCAGATCTGTCAGGCCGGGTATCCCACACCAgagaaatataaacaacatatGAGAAACCATGCATCCCTCCCAGTTTATAAATGCGAATTATGCGACAGAACGTTCAGTGATTCAAGTAATTTTACTAAGCATAAAAAAGTGCATAATTTAAAAGTGATTATTTGTGATTTGTGCGGCAAGAAATTTCAGTCGAAGGCTAAACTGGCTGTGCATAttgaaCAACATGAGACTACATCTCCTTTGGCGTGCGACAAATGCGACAAAGTCTTTTACTTCGAGTCCGGTTATCGTCGTCACGTCAAAAATAATCACGAAAGAATAGGTTTTGGATACCCCTGTGTTATTTGCAATCTCCGTTTCAGCTCCTTAAAGTATAAATGGGATCATATGTGGGAAGTtcataaagaaagaaaacataaGGCAGACTGTCCAATATGTTTTAAatcttttagaaaatatagCGATGTACGCGCCCATACTAAGCTTGTTCATCAGACAGAAGTTTCGGTGTTAAGAGTGAAAAATGCATCGAAGACTGTTAGTGATATAcagttgattttaaataattctgaTATTAAGATTGGAGAGGCTGAAACTTTAGTTATTGTTGATGATGACGATTCATAG
Protein Sequence
MAEASRKRSRKSKIVLRDVALDDEDDIELQLPTKSKKVIIKKEPKKESAAKKPARKTTKINQAVDKSVLDKIKAPIETNIEEPTPRFDINVEIEVETCDDENFDTNDENYDQSTEQIKDVEESSNKIKIKKEIKNVILSRETVIRESNKIKETSTNLADSILDICLRNSLGFFEEQHLSTWYDIQIKHVLTSWEDWQSKSFHREHPLFYKCYICTKSWWNLSEFRDHILEHTTVKLDIEKYTQHECNIIAFKPNKRPDEIKEFFTEGLCYHCGKDYSKHQLSARDDKNCYMNTDCLKRFPTCTELKHHAYACKVCSIKNNEYSFCCQICTLSFGKIDDLTGHMLLMHSVKSDRPIAANYSKCKDCSEVHSSSMIHTCGNKEANTMCPYCFKSFSNKSLILDHISRSTVPWHCKICSEEVKWSCTIHEHLLTHTDKYMFVKICVKCEGIHVFLDDREAKLHMMEKHGYNDFDRNFLKIPVPVSCIYSDEEKCEQEETLQDKLLPEFSQTQNVGVFIPNPESVFRRVSILKRSHKQQKIVLKPQESILKLKSLSDHSESVDSKANILIPALNEQNSVFEKQENATENVMDIVKVKEEPIDSDDSSNLVIKEEPMDFDYDDYAIQDNTTNTIQESAHADYDEDIVKSENSEYEDDIIKLNINIEDILAKQESSRVFAFEPDSKIKSEPAIDTNIEVDKDSILEPEVIISQEGEERKRLYGCSKCPFKGKQENYLRHITLDCLYSTVGNRKKFICVRTGQFYKTIKKYLLHFLEHGYEPLCCPDCSKQFHTYSKLGSHVLGHVKQNFVRIKKISERLVADAKPEYQCRKCLKIVILQEYFQHWESHICDANVPEKKEVVAAPRLVTDMSETAIQECIKTLQRKPKDCVYCKRRFQRVNECKRHVIEHLLMDAYTQKQILGLLKCQICQAGYPTPEKYKQHMRNHASLPVYKCELCDRTFSDSSNFTKHKKVHNLKVIICDLCGKKFQSKAKLAVHIEQHETTSPLACDKCDKVFYFESGYRRHVKNNHERIGFGYPCVICNLRFSSLKYKWDHMWEVHKERKHKADCPICFKSFRKYSDVRAHTKLVHQTEVSVLRVKNASKTVSDIQLILNNSDIKIGEAETLVIVDDDDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-