Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 5.4e-08 3.8e-06 27.1 1.7 1 23 205 227 205 227 0.99

2 5 0.00095 0.067 13.8 0.0 2 23 237 258 236 258 0.97

3 5 6e-06 0.00043 20.7 0.2 1 23 262 284 262 284 0.97

4 5 2.5e-08 1.8e-06 28.2 0.6 3 23 292 312 290 312 0.97

5 5 3.4e-05 0.0024 18.3 2.2 1 21 318 338 318 339 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	5.4e-08	3.8e-06	27.1	1.7	1	23	205	227	205	227	0.99
2	5	0.00095	0.067	13.8	0.0	2	23	237	258	236	258	0.97
3	5	6e-06	0.00043	20.7	0.2	1	23	262	284	262	284	0.97
4	5	2.5e-08	1.8e-06	28.2	0.6	3	23	292	312	290	312	0.97
5	5	3.4e-05	0.0024	18.3	2.2	1	21	318	338	318	339	0.95

Coding Sequence: ATGAAAGGGTACACCGAGGAGCAGCCTTCCACGCAGTTCACCGCGCAGCTCCCGAGTGAGGTGAGCCAGGCCCCCGCCGGCCCCGCCCCCGCTCCTCAGCCGGCGCTTCAGCCTCTATCCTATGCCCTTCTGCAACTCTCCGCCTCCGACTCGACAGACCCGCCCTTCCTCCAGGTACAGCTCCAGTCTTCGCCTGTCTCCCCTCCTCCGCCACCGGCGAGCGGCAAGTCCATCTCCATGTGCTACACCAGCACGGGTGCCATCCTCTCTCTGCCACCCAAGAAGAAAGATATCTACCGGCCGTACTGCCTCGTGGACCGAGCGGCACATCTCAACCGGCCCGAGGAGGACCTCAACGCGGCGCATGCCATCCTCGACCTCAGCCAGCACCCCGTGTTCCTGTCGCCGCCACGCGTGGAGCCGGCGCCCCccgagccgccgccgccgccccccCCGTCTGAACAGCCCACGCAAGAGCTCTCCGCTGAACGACCGCGAGAGACTATCGCATATACATATGATGCATTTTTCGTGAGTGATGGCCGCTCCAAAAGGAGAAATTATGCGAATGCTCCGGTCGAGACAGTACCGCCACCGGAACCCAAATCAAAATATACGTGCAGTGAATGCGGCAAGCGGTACGCGACGTCGTCGAACTTGTCGCGACACAAGCAGACGCACCGCAGCCTGGACTCGGTGGCGGCCAAGCGCTGCGGCGAGTGCGGCAAGGCGTACGTGTCCATGCCGGCGCTGGCCATGCACGTGCTGACGCACCAACTGTCACACGTGTGCGGCGTGTGTGGGAAGTTATTCTCGCGACCGTGGCTACTGCAAGGACACCTGCGTTCTCACACGGGAGAAAAACCTTATGGCTGCGCGCACTGCGGCAAAGCTTTTGCGGATCGATCGAATCTGCGTGCACACATGCAAACACATTCAGCAGATAAAAACTTTGAGTGCACACGATGCCACAAAACATTTGCACTCAAGAGCTACCTCAATAAACACCAAGAGTCGGCGTGCGTGCGCGACGACGACGACGAGTCGCCTTCGCCCGAACCTGCCGCGCCCGTATCCGCGTCCGGCTAA
Protein Sequence: MKGYTEEQPSTQFTAQLPSEVSQAPAGPAPAPQPALQPLSYALLQLSASDSTDPPFLQVQLQSSPVSPPPPPASGKSISMCYTSTGAILSLPPKKKDIYRPYCLVDRAAHLNRPEEDLNAAHAILDLSQHPVFLSPPRVEPAPPEPPPPPPPSEQPTQELSAERPRETIAYTYDAFFVSDGRSKRRNYANAPVETVPPPEPKSKYTCSECGKRYATSSNLSRHKQTHRSLDSVAAKRCGECGKAYVSMPALAMHVLTHQLSHVCGVCGKLFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNLRAHMQTHSADKNFECTRCHKTFALKSYLNKHQESACVRDDDDESPSPEPAAPVSASG

Sequence clustering based on sequence similarity using MMseqs2