Basic Information

Gene Symbol
-
Assembly
GCA_917862395.2
Location
OU860787.2:7642800-7649894[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0013 0.093 13.6 1.8 1 22 37 58 37 58 0.95
2 13 0.0088 0.65 11.0 4.8 1 23 74 97 74 97 0.96
3 13 0.14 11 7.2 0.5 2 23 105 127 104 127 0.95
4 13 6.8e-05 0.005 17.6 1.9 1 21 132 152 132 153 0.95
5 13 1.8e-06 0.00013 22.6 0.6 1 23 164 187 164 187 0.97
6 13 0.25 19 6.4 4.0 1 23 193 216 193 216 0.95
7 13 2.9e-05 0.0021 18.8 0.3 1 23 222 244 222 244 0.98
8 13 0.042 3.1 8.9 0.5 1 23 249 271 249 271 0.97
9 13 2.4e-05 0.0018 19.1 2.6 1 23 277 299 277 299 0.99
10 13 3.6e-05 0.0027 18.5 0.6 2 23 303 324 302 324 0.97
11 13 2.7 2e+02 3.2 0.0 9 23 343 357 332 357 0.88
12 13 0.00026 0.019 15.8 5.7 1 23 363 385 363 385 0.98
13 13 1.8 1.3e+02 3.7 0.1 3 23 393 416 392 416 0.83

Sequence Information

Coding Sequence
ATGACGCACAAACGTAAAAGATTAGGACGGCCCCCAGGAtctaaaaacaagaaaaacaagAACTTAGAGAACATAATTAAGAACGAAGGTGATTCTAATGAATGTACACACGTTTGTACTTTTTGCTCAATATCTTTTAAGACAAAATTAAGTTTGAAAGATCACCTTAAGACTTGTAGGAAAACGGTTTTGGATCGTGTTGATGTTTTAaagcCTACTTATAATTGCAAGCAATGTTCCAAgaagtttcaatttaaaaaaagttatacaacTCATCTACAAAATGAGCATTCAAAGACACCGGGAAGCATTGAATGTTCACAATGCTCTGTTAAATGCCCCAATGAAGAAGTTTTgtcaaaacatattaaaaatgtacatgAGAGGGAAATATTTGAATGTGAGCACTGCGAAAAAAAGTTTGTGAGACGTTCACATGTGTTACGACATCTGTTGCAGAGAGGTTGTGATGGTAGAAATATTGTTGTACACCCATGTGAAATTTGTTCTGCATCATTTACAAGGAGAGATAATTTGGTGGTCCATTTGCGCACACAACATTTATCAAATGAATTCTTTAACTGCAAGTTCTgtgattttcatacaaaaaacttTTCAAAACTGATTATCCATAATATTACTAACCATACAGAAACTCCGCATTTTGAATGTGACCATTGTGGCAAAGTGACTAGTTCTCGTGGTGCTATGGCCAAACATTTAGAAATACATGGGGAAAAAAAATTTTCATGTGATGTGtGTGGTTACAGCACGTTCACAATAGAAGTAATGCGCCGCCATGTTTTTACACATTCGACAGAAAAACcatacaaatgtaaattttgtGACAATTCTTACATACAGAAAGTACAATTGCAAAGACACCTGCAAAAACACACGGGCAACCAGTGCTCAATATGTAAAGAAACATTCACGTCTAAAGCTgaTCTTCTTATTCACACTAAGGAACATATGGGCGTAATCAAGTTATTGTGTCCTATTGATGGTTGTTCTTATGGTAAAGCAGAGTTTGAGAATGAGAAGGCTTTACAGAGACATGTTACAATGCATTTGGATGATAAACCGCACCAGTGCGAGGTGTGCTCGAAGCGGTTCCACAACGAGATGAACATGCGGCGCCACATGAGCACGCACGCGCTGGAGCGGCCGCGGCGCTGCATGTACTGCGTGGCGGCGCGCGCCTACGTGCGCGGCGAGCAGCTCGTGCGCCACGTGCGCAAGGCGCACCCGCACGTGTTCCGCGAGCGCCTCATGCACGTGCGCCAAGTGCTGGGTGCTAACCTCAGAACGGAGAGAGTGAAAAAGTCCGAGTTAGAGTCAATCTTGAATGTATTGGACGCGGAGTCAGACCGTATTCTGGAGGGGTACGGCTCGGGAGTGCTATACGGCGGGTTACAGGAGCAGTTCGACGTGGAGGACGAAGAGATAGAGGTGGAAATCAACTCTCCCTTAATGTGCGAAGAGGAGTTAATAGATAATATCGGAAAGCTGCTCTCACAGCTGATCGATAAAGATATGTTGGAGTGCTTCGGGTGGCCTGATGCAAGTGTTGATGAGGTATTAGAAAAAGTCATAGAAAATTGTGGTGCTCAACCTGCAGACAAAGAAAAATGGACCAGGGTTCAATGTCTGAGGGAGAATGctaaacatttgtttttatatgtaatagagGATAAGAATATTGCGAAAATGTTCGATAGCCACACTATAGACCAGGTTATTACGCATATACTGGCACAAGTGTGCAAGTccaatgatgatgataatgatgatgataatgatgatgatgatgatgacaatGATGGTGATAATGAGGATAATAAgggtaacataaaaattaaataa
Protein Sequence
MTHKRKRLGRPPGSKNKKNKNLENIIKNEGDSNECTHVCTFCSISFKTKLSLKDHLKTCRKTVLDRVDVLKPTYNCKQCSKKFQFKKSYTTHLQNEHSKTPGSIECSQCSVKCPNEEVLSKHIKNVHEREIFECEHCEKKFVRRSHVLRHLLQRGCDGRNIVVHPCEICSASFTRRDNLVVHLRTQHLSNEFFNCKFCDFHTKNFSKLIIHNITNHTETPHFECDHCGKVTSSRGAMAKHLEIHGEKKFSCDVCGYSTFTIEVMRRHVFTHSTEKPYKCKFCDNSYIQKVQLQRHLQKHTGNQCSICKETFTSKADLLIHTKEHMGVIKLLCPIDGCSYGKAEFENEKALQRHVTMHLDDKPHQCEVCSKRFHNEMNMRRHMSTHALERPRRCMYCVAARAYVRGEQLVRHVRKAHPHVFRERLMHVRQVLGANLRTERVKKSELESILNVLDAESDRILEGYGSGVLYGGLQEQFDVEDEEIEVEINSPLMCEEELIDNIGKLLSQLIDKDMLECFGWPDASVDEVLEKVIENCGAQPADKEKWTRVQCLRENAKHLFLYVIEDKNIAKMFDSHTIDQVITHILAQVCKSNDDDNDDDNDDDDDDNDGDNEDNKGNIKIK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00781225;
90% Identity
iTF_00776204; iTF_00775486;
80% Identity
-