Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 2.7e-05 0.002 18.6 0.4 3 23 84 107 83 107 0.95

2 5 2.6e-05 0.002 18.6 0.3 1 23 113 135 113 135 0.98

3 5 6.8e-05 0.0052 17.3 0.1 2 23 141 162 140 162 0.97

4 5 4.6e-05 0.0035 17.9 4.9 1 23 168 191 168 191 0.95

5 5 1.9e-05 0.0015 19.1 3.4 2 22 196 216 195 216 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	2.7e-05	0.002	18.6	0.4	3	23	84	107	83	107	0.95
2	5	2.6e-05	0.002	18.6	0.3	1	23	113	135	113	135	0.98
3	5	6.8e-05	0.0052	17.3	0.1	2	23	141	162	140	162	0.97
4	5	4.6e-05	0.0035	17.9	4.9	1	23	168	191	168	191	0.95
5	5	1.9e-05	0.0015	19.1	3.4	2	22	196	216	195	216	0.94

Coding Sequence: atggctTCTGTATCTGATAATTTTGGAGATGATATAGAAAATGaagatccTTTATGTGGTTTGGACTTATACaaagaacatttttataatttagagtcTAACGTGTTCGCTGAACCTCTAGAACGTTTAAAtgataATATTGGCAATCCAAGTAGTGAATTTAAATTCTACGACAATATAACAGTTGAAACAACTTTAGAAAACAGAAAGAAATATCACATTCCCATAGAAGATCCATTGAAAGCAATTTGTCCAAATgcAAATTGCAAAAAAGAATTTTCATCTCAATATGTGTTAAAATCTCATATTCGTAAAGTACACTGtgctgaatataaatatatgtgtgaAATTTGTGGAAGAAAATTCACTGCCGATTATTTATTGGTGCGGCACAAAATGGTACATGATAAGAGAACTGTTGAGTGTGCTGTGTGCGGCAAGACATTGAGTGGAAGGACAAATATGTCAGTACATTTACGAACTCACACTGATTCGAGACCACATAAGTGCGAAGTTTGTGAAAAAACATTTGTTAGAAAACGAtgcttaaatttacatattaaatttgtacataataaggaaataaaatgtcaCAAATGTGGCAAACGGTTTCCAAAGCGACACCAGCTCGCCCATCACGTGCAAACATGCTGA
Protein Sequence: MASVSDNFGDDIENEDPLCGLDLYKEHFYNLESNVFAEPLERLNDNIGNPSSEFKFYDNITVETTLENRKKYHIPIEDPLKAICPNANCKKEFSSQYVLKSHIRKVHCAEYKYMCEICGRKFTADYLLVRHKMVHDKRTVECAVCGKTLSGRTNMSVHLRTHTDSRPHKCEVCEKTFVRKRCLNLHIKFVHNKEIKCHKCGKRFPKRHQLAHHVQTC

Sequence clustering based on sequence similarity using MMseqs2