Basic Information

Gene Symbol
-
Assembly
GCA_030704555.1
Location
CM060809.1:14589865-14592828[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0018 0.14 13.2 4.1 1 23 159 182 159 182 0.98
2 17 0.00013 0.01 16.8 2.1 1 23 191 214 191 214 0.97
3 17 0.017 1.3 10.2 0.3 2 23 227 249 227 249 0.97
4 17 0.00052 0.04 14.9 1.3 1 23 258 281 258 281 0.97
5 17 3.9e-05 0.003 18.5 1.3 1 23 293 316 293 316 0.97
6 17 1.2e-05 0.00096 20.0 0.7 2 23 344 366 343 366 0.97
7 17 0.00041 0.031 15.2 1.3 2 23 376 398 375 398 0.96
8 17 0.029 2.2 9.4 1.1 2 19 403 420 402 423 0.92
9 17 0.0017 0.13 13.3 3.5 2 21 428 447 427 450 0.94
10 17 0.011 0.88 10.7 1.3 2 23 459 481 458 481 0.94
11 17 0.0018 0.14 13.2 2.9 1 23 486 509 486 509 0.96
12 17 0.00011 0.0081 17.1 0.5 2 23 520 542 519 542 0.96
13 17 0.00062 0.048 14.7 0.6 1 23 568 591 568 591 0.92
14 17 0.0023 0.18 12.9 0.6 2 23 625 646 624 646 0.97
15 17 1.5 1.2e+02 4.0 0.4 3 23 654 676 652 676 0.91
16 17 0.015 1.2 10.3 0.2 1 23 712 734 712 734 0.97
17 17 0.19 14 6.9 2.0 1 23 740 763 740 763 0.96

Sequence Information

Coding Sequence
atgtcaaTAAAAGAAGATAGAATGAACATTAGCAATGTTAAAGCAGATAAAGATGAGTTAGATAGTAGAAAGGACCCAACTTCATTCCTTCCTGATGAACCTATGACATATGAATTAAAaacgaagaaaaagaaaaaaaagaaaaaacaagagGATCCATTTAAagatattgaagaaaaaattacaCTGCCTATAACAACAGTATTTGAATCCACAACAGAAAGTGAAGTGGATACAAAGCAAGTGCTGGACCcagaagttaatataaaagtGGAAAATATTGAAGTTGAACTGGATTTTAATGATtTTGCAAATGACAACGGATTAATGTTAGAAGGTCCACAGAGTGAAGACAGTCAGGAACCAGTAGTCAAAATTGAAGAACAAAACCGCGAAGCAGTGTTACTTACGTTTGAAAGCATTATAAGTGATAAAAGTGTTATAGGTTTCGGACCTATCGCGCCAGCACCCAACTACGTCTGCAAAGTTTGCCATTTGGTGTTTCAATCAACAAAAACATTAAGGATGCatcaaaaaagaaaacacaaagTATTTCGGAAATCCTTCAAATATATATGCCATTATTGCTCTATGTCATACGAACAGAAGAATAGCTTGGTTGcccatataaaaagaaaacatggaCCTGATTCGTCAAATGATGATGGTGAAGAAAGAACATGTGAAATTTGTGCTTTAGTTTTCAAGGGAATTGCCAGATTAAGAATGCATATGCGGAGAAAACATGGTTCTTTTGAAGATTCTTTCAAGCATGTATGCAAAGAATGCGGTTTAACTTATGATAAATATAGAAGTTTAATAGTTCACATACAAAGGAAGCATTCAATTGATAAAAAACCGGTGCTAGACCAGTGGTACAATTGTCCATTTTGCCCGAAAGTTTTTACGAAAAGAGAAACTTATGCAAGACATGTGCAAAGAAAACATCGTGTTAACGACGAAGATGAAGTCAAGGAAGAATCGGGAACTTTactcgaaaatataaaaaatgaaactacAGGTGAAATAACGTGTAAAGAGTGTCCATTAGTGTTTTCATCACTCAATTACTTAAAGCTACATATGAGAAGAAAGCATAATGCCCTAAAAGAAGATTTTCGTCTAAAATGTCGAATTTGCAATTTGTCATATGATAAAATTGAAAGCTTGAAACGGCATATACGACGGAAACACGACAAAGGATCGTATTGTGACGTGTGCGATAAACAATTCGAAACTAGAGAAACTTATCTTAATCATAGTCATAAAAGAATGGTCCAAGAGTGCCATATTTGCGGTCTCATATTCGCTTCACAAGGCGGTTTGTGCAAACATTTAAGATGTACACACAAAATACAGTCCCCCAAAACTATTGTGTGCAATCTGTGCAATGAAACGTTTCACGATAAACGACAATTAAAACCACATTACTTAAAAGTCCATTTAAAGGTTTCATACACATGCGCCTTTTGCCACAAAATCTTTAAAGCTAAAGAAAGTTATAGAAGACacgttttaataaaacacccgtcaaatactataaaaattaacGAACAACAGTGTGATAAATGTCCAGAGAAATTTCCAGATGAATTTGAATTATGCCGCCATATTAATATAGCACACGGGATAACCCAAAACGGTGAAACGGGAAATGAGttgttggaaataaaaaaagaggaaGTAGACATTCCAGATACGTTCCAATGTTCGAAATGTCCAGAAAATTATAACAGCTGGGATGAATTGAAGTTACATTTCGAACAAAATCACCTTATGGTAGCAGTGACGCAGTGCCAAGTTTGTGGTGAAATGGTTCCTGGAAACGAACTAGATAAGCATTTTAAGAGTTTTCACACAATAACTTCAGTTGAATGCAAATATTGTGAATTCGAAACATCCAATCGTGCTAGTATGACACAGCACATGTTGCGACATAAAAATGCACACACAATAAACTGCGATTTCCCCGGTTGTAGatacaaaacatattatgaagGTGCTATGGAGAAACACAAAAGAAAACACAGAGACCAAGGTGTCAAGTTACAATGTACGCAGTGTCCTTTCCAAACAATGAAtaagtatatacttaaatatcatGAAGAAGCCCATGTTACAGGAAAAAAGAGATATTCCTGTGACCAGTGTGATTATGCAACAATACTTCCAGCTAATTTGGTTCAgcacaaatataaacattcatcAGAAAAGAGATTCAAATGTGAAGTCTGTCCGTTCGCAACTAAGTACAACACGTCGTTACGTTTTCACGTTAAAAAGAAACACTGTGATCTCCCAACATTCAGTTAG
Protein Sequence
MSIKEDRMNISNVKADKDELDSRKDPTSFLPDEPMTYELKTKKKKKKKKQEDPFKDIEEKITLPITTVFESTTESEVDTKQVLDPEVNIKVENIEVELDFNDFANDNGLMLEGPQSEDSQEPVVKIEEQNREAVLLTFESIISDKSVIGFGPIAPAPNYVCKVCHLVFQSTKTLRMHQKRKHKVFRKSFKYICHYCSMSYEQKNSLVAHIKRKHGPDSSNDDGEERTCEICALVFKGIARLRMHMRRKHGSFEDSFKHVCKECGLTYDKYRSLIVHIQRKHSIDKKPVLDQWYNCPFCPKVFTKRETYARHVQRKHRVNDEDEVKEESGTLLENIKNETTGEITCKECPLVFSSLNYLKLHMRRKHNALKEDFRLKCRICNLSYDKIESLKRHIRRKHDKGSYCDVCDKQFETRETYLNHSHKRMVQECHICGLIFASQGGLCKHLRCTHKIQSPKTIVCNLCNETFHDKRQLKPHYLKVHLKVSYTCAFCHKIFKAKESYRRHVLIKHPSNTIKINEQQCDKCPEKFPDEFELCRHINIAHGITQNGETGNELLEIKKEEVDIPDTFQCSKCPENYNSWDELKLHFEQNHLMVAVTQCQVCGEMVPGNELDKHFKSFHTITSVECKYCEFETSNRASMTQHMLRHKNAHTINCDFPGCRYKTYYEGAMEKHKRKHRDQGVKLQCTQCPFQTMNKYILKYHEEAHVTGKKRYSCDQCDYATILPANLVQHKYKHSSEKRFKCEVCPFATKYNTSLRFHVKKKHCDLPTFS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01033959;
90% Identity
iTF_00457407;
80% Identity
-