Basic Information

Gene Symbol
-
Assembly
GCA_905332915.1
Location
HG995312.1:13768181-13776239[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.024 2.5 9.8 0.1 1 23 214 236 214 236 0.96
2 12 0.00055 0.058 14.9 1.1 1 23 242 265 242 265 0.94
3 12 0.53 56 5.5 1.1 1 23 279 301 279 301 0.93
4 12 6.8e-05 0.0073 17.8 2.5 1 23 546 568 546 568 0.97
5 12 0.033 3.5 9.3 4.7 2 23 574 596 573 596 0.96
6 12 0.00012 0.013 17.0 0.3 2 23 605 626 604 626 0.95
7 12 6.4e-05 0.0069 17.8 0.8 2 23 630 651 629 651 0.97
8 12 0.051 5.4 8.7 3.6 2 23 665 687 664 687 0.96
9 12 7e-06 0.00074 20.9 2.0 1 23 693 715 693 715 0.98
10 12 0.00064 0.069 14.7 1.9 2 23 722 743 722 743 0.98
11 12 0.0011 0.11 14.0 1.0 1 23 749 772 749 772 0.97
12 12 0.031 3.3 9.4 5.2 1 23 776 799 776 799 0.95

Sequence Information

Coding Sequence
ATGGATGAAGATATTTTTGCGGTATTAAGTCCcatgaaaaaatattcaaaacggTATAAAAAAGTGGAAAAAGCAACATCAGAGTCTAATAATATGGATAAGACCTCCAGACGAACAGGAAAGATCTATGATCCTGGTGTACCTCTGACTACTAAAGTTGCTGTAGAGTATTTGCTGAGTGGGAAGCTGAAGGCGAGTGCATGTCGTTACTGCCTAAAAGTAACGGTCGCGCTGTCTGAACTGGACCAGATAATGCAGATAGCTGGCAGGGGAGTCATGTATAAAGTGTCTATAAGAGAAATGATTGCCTGTTTCTATCCATTCAAGGTTAGACAAGAAGAAAGCTTCCCAGATAAAATCTGTCAGAGGTGCATAGACAGAGCTATTAAAGCATACCTCTTTACGCAACAGTGCGAACAGGCTGAAAGAGCTCTGCACAATTGGTTTGATGATATAAACGAGAAATTCAATAAACTAGACCCTGTtgatagaaagaaaaagagaggcagaaaaaaacaaaaaccaaactATAACACATTATATGTAGAACATCATAAAGTGATGGATTACGCTGAACCGTTACGAAATATCATCAACTTACAAACAGAATCATTGAGCAATGAACCAGATTGGAACGAATTTGAATGCAAAAAGTGCTGGCAAGTACTCCCAGACTTGGAATCGTTGCTGAACCACGAGCAAGGACATCCTAAACACATGTGGTACAACTGCCGATTGTGCGGTAAAtcttttgtaaaaatcaaccagttGATGAAACACTTCAACCAAGTCCATATAAAACGAAAGGGGGTTATCGAAGAAGCAGACAAGacttttaaatgccaagaatgTGGGAATGTAACAGACAATTATGCACAACATCTACAGCATATAGAAAAGCATAAGTTTAAGAGTGTAATGAAACATTTGATCGAGAAGAAAACGGACCAGCTCTGCCTGGTCTGTTTAAAGGAGAGTACACATCTGGTAGACTTGGATAAAACGGTGTGCATACATGGAAGCTGTCCTGAATTGGTTGGAGAAAAATCATTGTATACGGTGTTAGCATCAACCTTACCCGATATGAACTACCTACACAACTTTATCGGGACAAAAATATGCGAAAAGTGCTTTAATCACGCGATTACGTCATACATTTTCATACACCAGTTTAGTTTTACTAGAGAACGTTTAGATCTCTGCATCAGTCTCATGTTGGAGTACCTTAGCAAAATCACACCGAGTGCCAATGTGTTTGTGCAAGTGTCCCCACCTGTAATCATGGCCCCCCAAGAAGAGGCAGACGAAACTGTACTCCTAGATGACAATGATTTCATAGATGAGagcaaaattaaaatagaagttCTAGAAGATGAGTTTAGACTGAAATCTGAGAGTGAGAGTGAAAGCGAACCAGAAGATATTGATCGAATCGAACATTCTCAGTCTCCATCGAATAGGTTAAGTTCGGAAAATTCGACACCAGAAATGGAGAATTTAGCTAGCAATGCTACTAAGACTtatatgaaaagaaaaatggtaaacGGCTTGCAAAGTTCGCGATATCCTGTCGATGTATGCAGCGAATTTTTAAcgtttaacaaaagaaaaaaagtcgAAAAGGTCTCCTTTAAATTCACTTGCCCTGTCTGtagtaaacattttatatcggaatatttcttaaaaagacatattgtgaaacatttgaataagAAGGTTCAATGCAATTTATGCCATAATGTGTTCAAATCTAAGTTTTGTTTGTATGAGCATACTAAAATGGCGCATTTATTGAGAGAGAGCTTTTATATGTCTTGTAAAGTGTGCGGTAGGAACTATACAGACCCAGATAAGCTGCAAACTCATGAAGAAAGCCATAGAATTAAACCTTGTGATCTCTGCAATAAGGTCTATATTACCCAAGCACACTACGAGAACCACATACAAAGGCACGCAGTCAAATTGAAACttctaaaagaaaaacaatctcAAACGTGCAGTTTCTGCGAGAAAGAATGTTCAAACCACAATGAACTCTCTGTCCACGTcaataaaatccatttacaaataaaaccgTACAGTTGCGATATGTGTGATAGACAATTTTACACTGAAAGTAATTTGAAGAACCATAAAAAGGTtcatagtatgccttcgaaggAAACGTGTGAATTTTGTAACAAGACTCTTAGGAGTAGGAAACAATTAGTAATTCATGTTAGAAAACATATAGGGGCCAAGCCTTTTTGCTGCCAAGTTTGCGGTCAGGCATTCTACTCGGCTTTTAAAGCCAGAGAACACATGAGAATAGTGCACGGAGGGCGATTCTGTTGTAGAATATGCAAATCCTGTTTCGCAACCAAATATGGACTTAAAGATCACGTGAGTAGAGATCACAATTTCATTTAG
Protein Sequence
MDEDIFAVLSPMKKYSKRYKKVEKATSESNNMDKTSRRTGKIYDPGVPLTTKVAVEYLLSGKLKASACRYCLKVTVALSELDQIMQIAGRGVMYKVSIREMIACFYPFKVRQEESFPDKICQRCIDRAIKAYLFTQQCEQAERALHNWFDDINEKFNKLDPVDRKKKRGRKKQKPNYNTLYVEHHKVMDYAEPLRNIINLQTESLSNEPDWNEFECKKCWQVLPDLESLLNHEQGHPKHMWYNCRLCGKSFVKINQLMKHFNQVHIKRKGVIEEADKTFKCQECGNVTDNYAQHLQHIEKHKFKSVMKHLIEKKTDQLCLVCLKESTHLVDLDKTVCIHGSCPELVGEKSLYTVLASTLPDMNYLHNFIGTKICEKCFNHAITSYIFIHQFSFTRERLDLCISLMLEYLSKITPSANVFVQVSPPVIMAPQEEADETVLLDDNDFIDESKIKIEVLEDEFRLKSESESESEPEDIDRIEHSQSPSNRLSSENSTPEMENLASNATKTYMKRKMVNGLQSSRYPVDVCSEFLTFNKRKKVEKVSFKFTCPVCSKHFISEYFLKRHIVKHLNKKVQCNLCHNVFKSKFCLYEHTKMAHLLRESFYMSCKVCGRNYTDPDKLQTHEESHRIKPCDLCNKVYITQAHYENHIQRHAVKLKLLKEKQSQTCSFCEKECSNHNELSVHVNKIHLQIKPYSCDMCDRQFYTESNLKNHKKVHSMPSKETCEFCNKTLRSRKQLVIHVRKHIGAKPFCCQVCGQAFYSAFKAREHMRIVHGGRFCCRICKSCFATKYGLKDHVSRDHNFI*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00907334;
90% Identity
-
80% Identity
-