Basic Information

Gene Symbol
-
Assembly
GCA_905332915.1
Location
HG995316.1:4364299-4368521[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.05 5.4 8.7 2.1 1 23 253 275 253 275 0.97
2 10 0.018 2 10.1 0.4 2 23 302 324 301 324 0.93
3 10 0.00014 0.015 16.8 0.3 1 23 347 369 347 369 0.98
4 10 4.3e-05 0.0046 18.4 0.7 1 23 373 396 373 396 0.96
5 10 3.6e-05 0.0038 18.6 0.2 1 23 401 424 401 424 0.94
6 10 0.16 17 7.1 1.4 1 22 430 451 430 453 0.82
7 10 9.1e-08 9.7e-06 26.8 2.7 1 23 460 483 460 483 0.98
8 10 0.0017 0.18 13.4 4.3 1 23 489 511 489 511 0.98
9 10 5.5e-07 5.9e-05 24.3 1.7 1 23 517 539 517 539 0.98
10 10 8.8e-05 0.0094 17.4 2.1 1 23 545 567 545 568 0.95

Sequence Information

Coding Sequence
atggagaaaaaaaaaacgaatacgaGCTATGGAGAGTGTCGCTGTTGTTTAGCAAAAGGCTACCACAGAGATTTAATGAAAGAACACTATTTTAACGGCATTCGCGAAGTTTATTTCGACATTTTTATggaaagttttaatttatatTTATCAACAAATGCTCAATTAACTACACTTATATGTTCAACTTGCGTACAACGTCTTAGAGATGCGACCAGCTTCCGTATGATGGTGGTCAGTACTGAAAGGCAGCTGCTACAAGCAATTGATGGAGAAAATAAGGATACGGTGTTTGTTAATGTGAACGTAGACGAGAATACGCTGGACAGTCAGATAGATGTGAAGGTTGAGAGACAAACAGACGTGAAGGTGGAATTTGATGAAGAAATAGACGTGGTTGACTATGAATCGGACTACGTGCCTAGCGATTACGTATCAGATGGTCCTTCAGAAAACCTGGTAGATGGTGAGGCAGCTCTACTGGGTCGGTTCGCGCGTATTAAATTGCCTCCCCTACCGACCAGGCAGGTACTACCAGAAATATGTCCCGAATATTGTCGACAACTGGATTTGATGCAAGATATAAAAGTGCTACCAAAAACGATCTTAAAACTACTAGAAGATCAAGACAGCCGCCGTGCCTCGACCAATCCGCGCCGGGTCATCATATCAGAGAAGCTAGCCCATATAGTGAACGCTGGCACCATTCTAGAATGTTCCAACGTCACCCCCTTTAGGGGCCGAAGTCGAACCGGCTTCCCCTGCTTCTACTGCCGAAATAACTTCGAAAACCTCAACAAACTCCGCGACCATACCAACCAACACAAAaaatcagaaataaaaaatattctcaaGACTTACGGAGCTGAATGTCTAGTAGTTTACGTTGATGTGACGGATCTAAAATGCACTCTATGCGACAAAAGTATAACTAACATAAACGAAATGAAAAGTCATTTAACAAATGTACATAAAAAGAAATTGTATCTAGAATATACTGACAGAGTTATCCCTTTTAAATTGGCACAAAATGGCGCCTTCGAATGCCAAGTCTGTGGCTTTAACTTCGAAACGTTTGGCTCGATAGAACGGCATATGAATGTTCACTTCAGAAACTACGTCTGCAAAGAATGCGGTACAGGTTTTGCTACAAAATACCGACTAAAAGTACACTCGAAAAGCATGCATAATATGGGTAGTTTCCCTTGCGAGCAATGCGGCAAAGTATTTACGACACAGCAGAAAATTACAAACCACGTCAACGCCGTTCACAAGTTACTTAAACGATTCAAATGTACGAAATGTCCAGAGCGTTTCGCTGAGTACTTTAGAAGGCAAAAGCATTTGGTACAGGTCCATGGAGTAGCTCCACTAAAGTACAAATGCAATGTTTGCGACAAGAGCTTCGATAGACGGTACACTCTATCTCGACATATGAAGCGAGACCACTTGGAAGAACGAGATTTTCAATGCGAAACATGCTCATATAAATGCTTTactaaaaatgaattgagaGTCCACATGATCAAACACAACGGCGAGAGAATATTCGAATGTTCGGTTTGTAAAAAGTCGTATGCGAGAAAGAAAACTTTAAAAGAACATATGAGGATACATAACAATGATCGAAGGTTTGCTTGCGCGGTTTGTGGACAGGCCTTCGTCCAAAAATGCAGCCTAAAAGGACATTTAAAAACGCATCATTTAGAGTTTAGTTTGCAATAG
Protein Sequence
MEKKKTNTSYGECRCCLAKGYHRDLMKEHYFNGIREVYFDIFMESFNLYLSTNAQLTTLICSTCVQRLRDATSFRMMVVSTERQLLQAIDGENKDTVFVNVNVDENTLDSQIDVKVERQTDVKVEFDEEIDVVDYESDYVPSDYVSDGPSENLVDGEAALLGRFARIKLPPLPTRQVLPEICPEYCRQLDLMQDIKVLPKTILKLLEDQDSRRASTNPRRVIISEKLAHIVNAGTILECSNVTPFRGRSRTGFPCFYCRNNFENLNKLRDHTNQHKKSEIKNILKTYGAECLVVYVDVTDLKCTLCDKSITNINEMKSHLTNVHKKKLYLEYTDRVIPFKLAQNGAFECQVCGFNFETFGSIERHMNVHFRNYVCKECGTGFATKYRLKVHSKSMHNMGSFPCEQCGKVFTTQQKITNHVNAVHKLLKRFKCTKCPERFAEYFRRQKHLVQVHGVAPLKYKCNVCDKSFDRRYTLSRHMKRDHLEERDFQCETCSYKCFTKNELRVHMIKHNGERIFECSVCKKSYARKKTLKEHMRIHNNDRRFACAVCGQAFVQKCSLKGHLKTHHLEFSLQ*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00041131;
90% Identity
iTF_00238052;
80% Identity
-