Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00015 0.037 16.7 2.8 1 23 157 179 157 179 0.98

2 6 0.00011 0.027 17.2 5.5 1 23 185 207 185 207 0.96

3 6 2.4e-07 6.1e-05 25.5 1.4 3 23 215 235 213 235 0.96

4 6 2.3e-07 5.8e-05 25.6 1.6 1 23 241 263 241 263 0.98

5 6 9e-07 0.00023 23.7 0.6 1 23 269 291 269 291 0.98

6 6 5.1 1.3e+03 2.4 0.7 1 8 297 304 297 305 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00015	0.037	16.7	2.8	1	23	157	179	157	179	0.98
2	6	0.00011	0.027	17.2	5.5	1	23	185	207	185	207	0.96
3	6	2.4e-07	6.1e-05	25.5	1.4	3	23	215	235	213	235	0.96
4	6	2.3e-07	5.8e-05	25.6	1.6	1	23	241	263	241	263	0.98
5	6	9e-07	0.00023	23.7	0.6	1	23	269	291	269	291	0.98
6	6	5.1	1.3e+03	2.4	0.7	1	8	297	304	297	305	0.92

Coding Sequence: ATGGTATTTAACGAAGTCCACATAGATAAAATTTGTCGAACTTGTTTAACAACTGAGGGAGAAATGTGTTCCCTTCATTTTAAAAACGAAACCTTTACTTCTAGATTATTCGACATGTTATTAGCATGTTCCTCTTTACAAATTACAGAAAGCGATGGTCTCCCAGAACAGATTTGTTCTCAATGTGTAAGTAATGTAATTCAGGCATATTCGTTCCGTCAACTTTGTCAACAATCAGACCAGActttgaagaaatatttgaGTAAAGATAAAGATAATCAGTCTACGAAACACGGCAATGATAATCCAATAAATGGATTTGATCTATCATTGTTCGACGCGGAAAAAATAAATGGATTGTCTAGTAGGACTTCGAAAGTATCGAAAGAAAATTctaaaaagagaaaaaagtttTCCGATTGTACAGAAGAAAATTGTGATACTAATGATGATACGGACCAGCCTTTATATCCGTGCCAAGAATGTACACAGTGTTTTACTGTGTACCAAGATCTGAAAGTACATAAACAGACTCATACTAAAATAAATCaacatatttgtaaaatatgccAGCAACACTTTTCCAGTTCCAGTTCTTTATCACGTCATTTTAAGATCCATGCTGGTGTTAAGTCACATCTATGCTCAGAATGTGGCAAAGGCTTTACTAGAAGCGACGATTTAACTCAGCACGCTCGAACGCATACAGGAGAGCGTCCGTATTCATGTACTCTATGTAGAAAATCATTTACTCAGTCGTCTCAGTTACAAGAACATCTTAGAGCTCATGCTGACCAAAAGAGTTTCGTTTGTACCACATGTGGAAAAGCGTTCTCTAGGTATAATAGTCTGTCTGgtcatatgaaaatacataatgGTGGACGGAGTTATCCGTGTGGTGTCTGCGGAAAagggtaa
Protein Sequence: MVFNEVHIDKICRTCLTTEGEMCSLHFKNETFTSRLFDMLLACSSLQITESDGLPEQICSQCVSNVIQAYSFRQLCQQSDQTLKKYLSKDKDNQSTKHGNDNPINGFDLSLFDAEKINGLSSRTSKVSKENSKKRKKFSDCTEENCDTNDDTDQPLYPCQECTQCFTVYQDLKVHKQTHTKINQHICKICQQHFSSSSSLSRHFKIHAGVKSHLCSECGKGFTRSDDLTQHARTHTGERPYSCTLCRKSFTQSSQLQEHLRAHADQKSFVCTTCGKAFSRYNSLSGHMKIHNGGRSYPCGVCGKG

Sequence clustering based on sequence similarity using MMseqs2