Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 8.2e-07 0.00021 23.8 1.5 2 23 86 107 85 107 0.96

2 6 7.4e-06 0.0019 20.8 1.7 1 23 113 135 113 135 0.98

3 6 2.5e-05 0.0063 19.1 3.7 1 23 142 164 142 164 0.98

4 6 9.1e-06 0.0023 20.5 1.9 2 23 171 192 170 192 0.98

5 6 1.4e-07 3.7e-05 26.2 5.1 1 23 198 220 198 220 0.99

6 6 0.0026 0.66 12.8 3.4 2 20 227 245 226 247 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	8.2e-07	0.00021	23.8	1.5	2	23	86	107	85	107	0.96
2	6	7.4e-06	0.0019	20.8	1.7	1	23	113	135	113	135	0.98
3	6	2.5e-05	0.0063	19.1	3.7	1	23	142	164	142	164	0.98
4	6	9.1e-06	0.0023	20.5	1.9	2	23	171	192	170	192	0.98
5	6	1.4e-07	3.7e-05	26.2	5.1	1	23	198	220	198	220	0.99
6	6	0.0026	0.66	12.8	3.4	2	20	227	245	226	247	0.94

Coding Sequence: ATGGACACTCAACAACACACAGTTGGCGCTGTTATGGAAGACGAGGATACAACAACAATCACTAATTatcaaaagtttgaagaaatttacattaaagaagaaccgctggaagaaaATTGCGAGGCCAGTGAATTTTATGAAAATGCTTTGCAAAGTGTAAAGAAGACAGAATGtataaatgataatgataacCAGATCGACAATCAAATTGCTATAAATGATGATActcagaaaattaaaaattcaaatagatTATATTGTGCAGaatgtaataagagttttacgGACAAATCACGCATGACAAGGCATATGAAGATACACAAAGGAATTAGAGAATTTGAATGTAAAACGTgtaaaaagttgtttaaaacaaatactaGTTTGCAAAGTCACATAATAATTCACACTGCTAGACCACGAGCATATACATGTCACAcgtgtaataaatcatttttatacaattctaCTTTAAAAACCCATATGGCTGTTCATACTGGAATAAAAGCCTccaaatgtacaatatgcaataaacaatttacatttagaacTGCTCTATTCctccatatgaaaattcactcTGGAACAAAAGCATATAAATGTCAATCTTGTggtaaatcatttacacaatattctcatttaaaatcccacttgaatactcataaccaaataaaagacTTGCAGTGTACAGTctgcaataaattatttaaaaatcctaGAAGTTTTTCCAGACATAGGCATCACATAgtggattaa
Protein Sequence: MDTQQHTVGAVMEDEDTTTITNYQKFEEIYIKEEPLEENCEASEFYENALQSVKKTECINDNDNQIDNQIAINDDTQKIKNSNRLYCAECNKSFTDKSRMTRHMKIHKGIREFECKTCKKLFKTNTSLQSHIIIHTARPRAYTCHTCNKSFLYNSTLKTHMAVHTGIKASKCTICNKQFTFRTALFLHMKIHSGTKAYKCQSCGKSFTQYSHLKSHLNTHNQIKDLQCTVCNKLFKNPRSFSRHRHHIVD

Sequence clustering based on sequence similarity using MMseqs2