Hsub016164.1
Basic Information
- Insect
- Harpagoxenus sublaevis
- Gene Symbol
- lz
- Assembly
- GCA_030770355.1
- Location
- JASTWR010000124.1:213959-220957[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.3e-18 1.6e-14 55.0 0.3 93 129 21 57 15 57 0.96
Sequence Information
- Coding Sequence
- ATGCACAGGCTGGGTCCTGTCTCTGCAGATGACCGTTCCCATCATCGAGTATTAACCGCAGGAAAGAGCTTCAGCATCACCATTACTGTGTCGACGACGCCACCCCAAGTAGCGACCTACACGAGGGCGATTAAGGTGACCGTCGATGGACCACGGGAGCCACGATCGAAAACGAGGCAGCAACATCAGCAATTCCGCGCGCTCGGTCTAGGACAAAGGCCCTTCCTCGACGCGCCGACTTCGTTCAGGTCCCACCTGCGGGAACTCGAATCCTTCGGGAGGAATAAGCATCACCATCATCACAGCAGCAGTCACTTACACGACCAGCAGACTGGCAACAACGTCACCACGAATTCGGTTAGCGGTGCCTGCACCAACCCCAACAACACCGACCCGACCGCATCGCCGGCTTCCAGTACACACCTCGGGGCTACCGGCGGCTCTTCTGTTCATCAGGATTGCTACAAGCGCAGTCCTCAACACGGCGGTGAGTTCTGA
- Protein Sequence
- MHRLGPVSADDRSHHRVLTAGKSFSITITVSTTPPQVATYTRAIKVTVDGPREPRSKTRQQHQQFRALGLGQRPFLDAPTSFRSHLRELESFGRNKHHHHHSSSHLHDQQTGNNVTTNSVSGACTNPNNTDPTASPASSTHLGATGGSSVHQDCYKRSPQHGGEF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00129506;
- 90% Identity
- iTF_01408835; iTF_01422701; iTF_01407944; iTF_01405467;
- 80% Identity
- iTF_01408835;