Basic Information

Insect: Harmonia axyridis
Gene Symbol: lola
Assembly: None
Location: chr2:727174-808368[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 20 0.0012 0.1 13.6 5.2 1 21 17 37 17 38 0.93

2 20 1e-05 0.00092 20.0 2.7 2 23 47 69 47 69 0.96

3 20 4.5e-06 0.0004 21.2 3.7 1 21 82 102 82 103 0.96

4 20 9.6e-06 0.00086 20.1 0.7 3 23 113 134 112 134 0.97

5 20 2.2 2e+02 3.2 0.2 2 22 252 272 251 272 0.90

6 20 2.3 2e+02 3.2 2.6 2 20 294 312 294 314 0.91

7 20 8.6e-05 0.0077 17.1 0.4 1 21 379 399 379 400 0.94

8 20 0.0013 0.11 13.4 0.2 3 22 413 432 411 432 0.95

9 20 8.9e-05 0.0079 17.1 2.2 1 23 440 463 440 463 0.97

10 20 0.59 53 5.1 1.4 1 14 563 576 563 577 0.92

11 20 0.00067 0.059 14.3 0.4 2 21 576 595 575 596 0.93

12 20 0.039 3.5 8.8 5.0 1 21 639 659 639 660 0.90

13 20 2.6e-05 0.0024 18.8 1.2 1 19 667 685 667 688 0.94

14 20 0.00034 0.031 15.2 1.3 1 21 797 817 797 818 0.94

15 20 0.051 4.6 8.4 4.3 1 23 826 848 826 848 0.98

16 20 0.00052 0.046 14.7 2.0 1 21 892 912 892 913 0.95

17 20 1.6 1.4e+02 3.7 2.0 1 13 921 933 921 934 0.90

18 20 0.0012 0.11 13.5 1.9 1 21 935 955 935 956 0.95

19 20 1.9e-05 0.0017 19.2 1.0 1 20 964 983 964 985 0.95

20 20 0.096 8.6 7.5 10.8 1 21 994 1014 994 1015 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	20	0.0012	0.1	13.6	5.2	1	21	17	37	17	38	0.93
2	20	1e-05	0.00092	20.0	2.7	2	23	47	69	47	69	0.96
3	20	4.5e-06	0.0004	21.2	3.7	1	21	82	102	82	103	0.96
4	20	9.6e-06	0.00086	20.1	0.7	3	23	113	134	112	134	0.97
5	20	2.2	2e+02	3.2	0.2	2	22	252	272	251	272	0.90
6	20	2.3	2e+02	3.2	2.6	2	20	294	312	294	314	0.91
7	20	8.6e-05	0.0077	17.1	0.4	1	21	379	399	379	400	0.94
8	20	0.0013	0.11	13.4	0.2	3	22	413	432	411	432	0.95
9	20	8.9e-05	0.0079	17.1	2.2	1	23	440	463	440	463	0.97
10	20	0.59	53	5.1	1.4	1	14	563	576	563	577	0.92
11	20	0.00067	0.059	14.3	0.4	2	21	576	595	575	596	0.93
12	20	0.039	3.5	8.8	5.0	1	21	639	659	639	660	0.90
13	20	2.6e-05	0.0024	18.8	1.2	1	19	667	685	667	688	0.94
14	20	0.00034	0.031	15.2	1.3	1	21	797	817	797	818	0.94
15	20	0.051	4.6	8.4	4.3	1	23	826	848	826	848	0.98
16	20	0.00052	0.046	14.7	2.0	1	21	892	912	892	913	0.95
17	20	1.6	1.4e+02	3.7	2.0	1	13	921	933	921	934	0.90
18	20	0.0012	0.11	13.5	1.9	1	21	935	955	935	956	0.95
19	20	1.9e-05	0.0017	19.2	1.0	1	20	964	983	964	985	0.95
20	20	0.096	8.6	7.5	10.8	1	21	994	1014	994	1015	0.95

Sequence Information

Coding Sequence: ATGCAAATTTTGTCAAAAAAAATTCAAGCAAAAGTTGCATATGATGGATATTTGTGTCCCAACTGTAACAAATCATATAAGCATAGATGTAACCTGTATCGTCATCTCAAATACGAATGTCGTAAGAAAGGAACTGAAGTTTGTCCAGTTTGTAAGAAAGTTTTCAAGCATAAACATAATATGAGAGCACATTTGATTACTGTTCATAGAGACGAAAAAGAAGAGGAAGTAGATAATAGTGGTTTTGAGTGTCCTAATTGCAAGAAAACTTATAAACATAGATTCAACCTGAATCGTCATATGAGATACGAGTGTCTTAAAAAGGGAAACGTGGCTTGTCCTATTTGTGACAAGATTTTCAAGTACAAACATAACATGAAAGCTCACTTGGATACTGTCCATAAAGATGAAGAAAGGGGGTCAGTTAAAATCCTGGGAAAACTCACATTTGGTGCTTTGCTTGGACATTTTATTGACACATGCGCAAGTTATTTCGCTGTGCGAAATGTTCAAAAGTTTATCAGTACAAGAGTTCTCTGTTGCGTCATCAGCGATATGAGTGCTCCAGAAAAGGATACTACACTTGCTCGTATTGTGGGAAATCCTTCAAATATGAGTATAAAATGCTCCACCACAAGGAGGCTTTACATCAAATTAGACAGTCCAGTTCTTTTTGAATTGGCCCCTCAAATCACTTACCATGTCCAAGTTGTGGAAAGAAGTGCGAAGGTAGTACCATATGGAAGACTTGATGAATGTGCTGCCTGTCTTCGTTGTTTTAAGGATGAAGAAGCCTGGACTATGCACAAGATGACGTCCCGGTGTAGTAGAAAATGGAGAAAGCTAAACCGTGCGAGGGTAACATATGGAGAACTTAACGAGTGTAGTATATGTCTCCATTGTTTCAAGGATACAAAAACTTGGGATAGGCATTGGCAATTTCAGTGTGTTAGATATAGAAAAGAAAACCGGTCGCCACAAACATTTCTAAGTAAACTACCACCTGCCCTTTATATCTCCATGATGTTGATGCGTGAAAATTTACAAAATTCTATTGCTGCCGATACTATGAATAATTTTGCTGCCTCAACTTCAACTCCAAAAATTAGACCAAATGTTCAGGATGTCTCAGGGCACGCTTGCCCTGTTTGTGATAGGGTCTATAAGTTGAAGAGCTCTTTGAGAAACCATCAGAAGTGGGAATGTGGCAAAGACCCTCAATTCAAGTTCTTTGGATGTGCAGAATGTGGAAAAAAGTACTCCAATGCTTTATCCCTACAAAGTCATCGACGTCGAGATTGTGGTACAGGAAAACAGTTTAAATGTGATATCTGTGGTTCTGGTTATAAGAGAAAATTTGATTTGAAGAAGCACCTTACACGACGTCATGTTTGTACAAGCGGCAAGCCGAGAAGAAGAAGAACTACTATAGAACAGTATGCGAAAGTTATGCTTGAAGTAACTTTCAAGAAAAACCAGAGACCCACAGCATCTGAACTTGAGATGCTCTCAGACGCACTCTGTATGCAGTTCGATACTGTCAGAACCTGGTTTCAAAATAGGAGAGCTAAGGAAAGAAAGATCAGGAATATTCCTCCAAGCCAAGATCCAGAATGTGGAAAACAATATGGAACAAAACAACATGCAATTTGTCACATAAAATTCGAATGTGGTGTTCAAGCCACTTTTCAGTGTCCATTATGTCCAAGGAAATGTGCTCGTTGGTACTGTGAAGCCTGTGGTAAATCTTACAAATACAAAATATCTTTACAGAGACATAAAAGGCACGAATGTGGTAAACCACCTCAAGTTGAGTGCTCCATCTGTGGTTTGAAAATTGTCGTTGGTATTGCGAAACCTGTGGTAAATCTTACAAATACAAAATATCTTTACAAAGGCACAAAAGATTTCCCTTACAAATGCGACTATTGTCACCGCACTTACAAGTACAAAGCCAACATGAAATTTCACAGAAAAAAATGCGGTATGGAACCACAGTATCGATGCGAAAAGTGCGACAAGAAATTCACTTCCAAATATGGTCTTCAAGTCCACTCGCTCAAAGTTTGTTCCAAGAATGCAGTTGGTTTAAGTGAGTTACCAGCACTCGGCGGTTTCTTCGGCAAGAACCCTTTGATGTTCAACAGTTGGGGAGGACAACAAGTATTGTCCTACGAGAATATTTACGCTAGAGAGATGACAACTTTATTGAGCAGATTGAGTGGACTGAAATATTTGAAAAAGTCGACCACATCGATGCTGGAAATGTGGAAAAGCCTACAAATGGGCTTGCAACCTAGGAAGGCACGTCAAGTTCGAATGCAATACGGAACCCAAGTTCCAATGTCAGATATGTCAAAAGAAATTCAAGCAAAAAGAAAACTGCTCCATAGCTGTAGGGCTTGTGGAAAACCGTATGCCACCAGGTCAACCTTAATGAGACATATGAAGCACGAGTGCGGGAAAGAACCTCCTTACAAATGTGCCTTTTGTGGATGTACAGCCTTCTATAATTTCAACATAATGAAACATATGAGGAAGCATCAGCATCTTTTGAAAAACGAGGAGAAAGTGACTGATTTCATCATCAAATTGGACAATTTGAAGATACGCTCTGTGGTCGAACTGCAGAGTACCGAAATATCTGTACCAGTTGTGGAAAGAGCTATAAATTATACTTGTGAGTTATGTGGTCGAGGGTACACACATAGAAGATCTCTTTATAGGCATACTAAATACGAGTGTTCCAAAAAGCCGAAATTCAAATGTCCTAATTGTGATTATAAAACAAAACAGAAAAATTATAATTGTGAGTTATGTGGTCGAGGGTACACACATAGAAGATCTCTTTATAGGCATACTAAATACGAGTGTTCCAAAAAGCCGAAATTCAAATGTCCTAATTGTGATTATAAAACGAAACAGAAAAGTAATTTAAATCAGCATATTTCTAATCGTGACCCGAATTCATCAGATTATTACAAATGCAAAGCTTGCAATCGCTGCTTTTGTTTCAAGAGGAACCTGACCCATCATCATAACAACGAATGTGATGAGAAATTGGACTGA
Protein Sequence: MQILSKKIQAKVAYDGYLCPNCNKSYKHRCNLYRHLKYECRKKGTEVCPVCKKVFKHKHNMRAHLITVHRDEKEEEVDNSGFECPNCKKTYKHRFNLNRHMRYECLKKGNVACPICDKIFKYKHNMKAHLDTVHKDEERGSVKILGKLTFGALLGHFIDTCASYFAVRNVQKFISTRVLCCVISDMSAPEKDTTLARIVGNPSNMSIKCSTTRRLYIKLDSPVLFELAPQITYHVQVVERSAKVVPYGRLDECAACLRCFKDEEAWTMHKMTSRCSRKWRKLNRARVTYGELNECSICLHCFKDTKTWDRHWQFQCVRYRKENRSPQTFLSKLPPALYISMMLMRENLQNSIAADTMNNFAASTSTPKIRPNVQDVSGHACPVCDRVYKLKSSLRNHQKWECGKDPQFKFFGCAECGKKYSNALSLQSHRRRDCGTGKQFKCDICGSGYKRKFDLKKHLTRRHVCTSGKPRRRRTTIEQYAKVMLEVTFKKNQRPTASELEMLSDALCMQFDTVRTWFQNRRAKERKIRNIPPSQDPECGKQYGTKQHAICHIKFECGVQATFQCPLCPRKCARWYCEACGKSYKYKISLQRHKRHECGKPPQVECSICGLKIVVGIAKPVVNLTNTKYLYKGTKDFPYKCDYCHRTYKYKANMKFHRKKCGMEPQYRCEKCDKKFTSKYGLQVHSLKVCSKNAVGLSELPALGGFFGKNPLMFNSWGGQQVLSYENIYAREMTTLLSRLSGLKYLKKSTTSMLEMWKSLQMGLQPRKARQVRMQYGTQVPMSDMSKEIQAKRKLLHSCRACGKPYATRSTLMRHMKHECGKEPPYKCAFCGCTAFYNFNIMKHMRKHQHLLKNEEKVTDFIIKLDNLKIRSVVELQSTEISVPVVERAINYTCELCGRGYTHRRSLYRHTKYECSKKPKFKCPNCDYKTKQKNYNCELCGRGYTHRRSLYRHTKYECSKKPKFKCPNCDYKTKQKSNLNQHISNRDPNSSDYYKCKACNRCFCFKRNLTHHHNNECDEKLD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00764577;
90% Identity: iTF_00764577;
80% Identity: iTF_00764577;