Basic Information

Gene Symbol
-
Assembly
GCA_000696795.2
Location
NW:1-25538[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00019 0.0075 16.2 4.5 1 23 139 161 139 161 0.98
2 10 0.00013 0.0051 16.7 4.0 1 23 167 189 167 189 0.96
3 10 2.3e-05 0.00091 19.1 6.0 1 23 195 217 195 217 0.99
4 10 1.5e-05 0.0006 19.6 4.4 1 23 223 245 223 245 0.97
5 10 1.3e-05 0.00054 19.8 1.5 1 23 251 273 251 273 0.96
6 10 0.0016 0.064 13.2 0.1 1 23 279 301 279 301 0.97
7 10 0.0025 0.098 12.7 0.2 2 22 307 327 306 327 0.95
8 10 1.2e-05 0.0005 19.9 0.0 3 23 352 372 351 372 0.98
9 10 1.1e-05 0.00043 20.1 0.6 1 21 403 423 403 424 0.93
10 10 1.2e-06 4.8e-05 23.1 3.4 1 23 435 457 435 457 0.98

Sequence Information

Coding Sequence
ATGTTAAGATGTAAGACTGAACGGATTTTGGATCCGATTAAAGTAGTTTCTGATCACCTTTCAGAGAGAATCACCCTGGAGTCCAATGAAGAGCCCATGccctattataataattctgtTTATAAACCTTCTGCACAGACCAGCATAGTGATAAAAGGCTCAAAACTAAAAAGTGAAGCCTCGAATAAGTTAGATGAGCCTGACAGTATGAATAACAATTTGATGTTTCGTAGTATGTTCTTCATGAATGACGAACCCAGACATTTTTTAGCACCAATACCTCTTTCGAATGAAACCGATTTTTTTCAACGAAAACCAGCATCTGCCAGTGGAAGCAGTCAGCAGAATGTTTCATCACAAACCGGGGAGCAAGTTATTCCTAATAAATTACCACCTCAGTATAAACAACGGCCTCATACTTGTGAAGAGTGTGGAAAGTCTTTTTTACTCAAACATCACCTTGCTACTCATATTCGTGTGCACACTGGAGAACGCCCTCATGTTTGTCCAGAATGTGGAAAGACATTTGCGTTAAAACATTGTCTTAGTACTCATCTTCTTTTGCATAGTGCCGAACGACCCTATAAGTGCAATGAGTGTAATAAGTCGTTTACGTTGAAGCATCATCTTgttagTCATGAAAAAATGCATACCAGGGACAGACCATTTGAATGTCGTGAATGTGGACAAACATTTTCTCAGAAAAGACACTTGAGTacacatttaaaatttcattctgGTGAACGACCTTTTTCCTGTCAGATCTGCGGTGAATCATTTTCAAGGGAAGAACATCTCGTGATGCATTCAAGATTTCATGGAGGTCTGCAACCCTATATTTGTCCCGACTGTGGGGCAGGTTTTCTCCGAAAATTTCAGTTGGTCGAGCATGAAAGGGAACATGGACGGGTTCCGGACACATGTCCTAATTGTGGAAAGGAATTTTTACAGAAACGTACCCTTCTTCTCCATGTCAGGACGTGTGGTCTGAATAATCAACACCACGGTTCTCATCCCCCAGAACATCAGCCAGTTACAAATCATTCAAAACTCTGCAAGGAGTGTGGAGAGTCTTTCGCCAGTGCAGAAGGTTTAGCCCTACACATGAGGTTACACGTCGGGGATCATAGCTTCCTCTCCGATATCTGTAGCCTCGCTGCTTCGCTTAAACAAGCTGCTGGCCAGGGTCTCCTCAAGCAGAAAACTCACGCTTGTTCCGAATGTGGCCGAGCTTTTACGCAAAAACATGGGCTCAACCAGCATATCCTCagGTATCCTAATGGTGCTtgtaaattaaaaccttttcgTTGTGAAAAATGCGGCAAGTCATTTTCTCAGAAAAACCACCTAGTCCTCCACGAGCGACAGCATATGGAACCTTCGGAGCGAAGTGAGCTGAACAGGCAACGCCAACCTAATCCTGCTATACCGCTCATTGGTCACATGGAGATGCCCCAGCACTCTCTCGACCAATAA
Protein Sequence
MLRCKTERILDPIKVVSDHLSERITLESNEEPMPYYNNSVYKPSAQTSIVIKGSKLKSEASNKLDEPDSMNNNLMFRSMFFMNDEPRHFLAPIPLSNETDFFQRKPASASGSSQQNVSSQTGEQVIPNKLPPQYKQRPHTCEECGKSFLLKHHLATHIRVHTGERPHVCPECGKTFALKHCLSTHLLLHSAERPYKCNECNKSFTLKHHLVSHEKMHTRDRPFECRECGQTFSQKRHLSTHLKFHSGERPFSCQICGESFSREEHLVMHSRFHGGLQPYICPDCGAGFLRKFQLVEHEREHGRVPDTCPNCGKEFLQKRTLLLHVRTCGLNNQHHGSHPPEHQPVTNHSKLCKECGESFASAEGLALHMRLHVGDHSFLSDICSLAASLKQAAGQGLLKQKTHACSECGRAFTQKHGLNQHILRYPNGACKLKPFRCEKCGKSFSQKNHLVLHERQHMEPSERSELNRQRQPNPAIPLIGHMEMPQHSLDQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01309652;
80% Identity
-