Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.035 2.6 9.1 0.6 1 20 97 116 97 118 0.92

2 6 6.6 4.9e+02 1.9 0.1 3 23 153 173 152 173 0.76

3 6 0.00013 0.0099 16.7 1.3 2 23 181 203 180 203 0.95

4 6 0.00012 0.009 16.8 1.1 2 23 211 233 210 233 0.96

5 6 0.041 3 8.9 8.9 1 23 240 263 240 263 0.96

6 6 0.00052 0.038 14.9 2.5 2 23 271 294 270 294 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.035	2.6	9.1	0.6	1	20	97	116	97	118	0.92
2	6	6.6	4.9e+02	1.9	0.1	3	23	153	173	152	173	0.76
3	6	0.00013	0.0099	16.7	1.3	2	23	181	203	180	203	0.95
4	6	0.00012	0.009	16.8	1.1	2	23	211	233	210	233	0.96
5	6	0.041	3	8.9	8.9	1	23	240	263	240	263	0.96
6	6	0.00052	0.038	14.9	2.5	2	23	271	294	270	294	0.96

Coding Sequence: ATGGAACTTGATACTGACCCATTGGAAGGGACAAGCTTCCAGTGCTGTGTCTCTGTGAAGGTAGAAATTAATGATGATGAGGATGATGAAGATGATTCTTGTAATATGGCCTTACTGGAGCTAGCACAATGTGTTCAAACAAACCAAGAACCAATCGAATACAACTCCACAGATGCCATGATGAATCCTAAAACAGGCCTCTTGGTGTGCCTCCACTGCCTCGAAGACCTAGAGCCCAACATGCTCTCCGATCACATGGTGAACGCTCACAACTACAGAAGAGTCCTATTCAAGTGCCAAATATGCCAAAACACATTCCAAGAGAGGAACTTATTATATGCACACAAAGCCAAATGCCGTCTTCCCACAAAACGCCGCAAACAGAAAACCTTTCAACAAATCATAAAGGAGCTCGACATGAGAACTGTGAATGAAAATGATTTTGAGATAGCCACATGCCCTTTATGCCTTTTAGAACTGCCGCAGTTCAATTTAAAAGACCATTTGATGGCTGAACATAGTAATCCAGATGTATCGATGACCTGCGGGAAGTGTAATAGGAATTTTAAGTCTAAACTCACGTTGAGAGAGCATATTAAGTTGGTGCATGAAGCCGTTGAGAATTCAGTGGAATGTAAGATGTGTGGACAGAAGTTCAGGTCTGTGAAGTATTTGTCTAACCACAAAAGGAATGTACATCCAACTGGAGACAAAGTGCACAAATGCACAGTCTGCAGCAAAGAATTCAAGACTCGTCTCTGCCTTCATCAACACACAAAATACGTCCATCCGCCGGAGAGTGCCTCCGTCGAATGCCCCCACTGTCCGAGCAAAATGTTTAAGAGCAAGATTAACTTGCATCAGCACCTGAAAGTGTCCCATGGGTTGAAGAAGAGTGATAATAAATAA
Protein Sequence: MELDTDPLEGTSFQCCVSVKVEINDDEDDEDDSCNMALLELAQCVQTNQEPIEYNSTDAMMNPKTGLLVCLHCLEDLEPNMLSDHMVNAHNYRRVLFKCQICQNTFQERNLLYAHKAKCRLPTKRRKQKTFQQIIKELDMRTVNENDFEIATCPLCLLELPQFNLKDHLMAEHSNPDVSMTCGKCNRNFKSKLTLREHIKLVHEAVENSVECKMCGQKFRSVKYLSNHKRNVHPTGDKVHKCTVCSKEFKTRLCLHQHTKYVHPPESASVECPHCPSKMFKSKINLHQHLKVSHGLKKSDNK

Sequence clustering based on sequence similarity using MMseqs2