Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0031 0.55 10.4 1.6 2 23 79 99 78 99 0.96

2 6 0.00031 0.054 13.6 4.2 1 23 106 128 106 128 0.96

3 6 6.5e-06 0.0011 18.9 1.4 1 23 134 156 134 156 0.99

4 6 1.7e-05 0.003 17.5 0.9 1 23 162 184 162 184 0.98

5 6 0.00068 0.12 12.5 1.8 1 23 189 212 189 212 0.93

6 6 2.6e-05 0.0046 16.9 3.5 1 23 218 241 218 241 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0031	0.55	10.4	1.6	2	23	79	99	78	99	0.96
2	6	0.00031	0.054	13.6	4.2	1	23	106	128	106	128	0.96
3	6	6.5e-06	0.0011	18.9	1.4	1	23	134	156	134	156	0.99
4	6	1.7e-05	0.003	17.5	0.9	1	23	162	184	162	184	0.98
5	6	0.00068	0.12	12.5	1.8	1	23	189	212	189	212	0.93
6	6	2.6e-05	0.0046	16.9	3.5	1	23	218	241	218	241	0.96

Coding Sequence: TTGGCTAAAGAAATCTCTGGCAGTGCCTTATTATTTAGAAAAACTGCAAAAGAATCCGAAGAAGTATTACGACGTTCTGTAAAAGAAGAGTTTGTATTTGAGCAGCAAGATCACGATTATACCGACAGCTTTGAGTCTAAGGATACTACACAAAATTGGTCAAGTAATGAAGAAGGAAATTCAAAGGAATTTAAAGTGAATAAAAGAGAGAAGATAAAGCAGACATCAAAAGTTACATGCCATGTTTGCAATAAAGTTATAAACAGATCATATTATAAAGAACATCTAACAATGCACGACCCTAACCACCTTAAATATGTGTGTGATGTTTGTGGGAAGTCATTTAGGTTAAGGTGCGCATATCACAATCACAGTTTGAGGCATAGGGAAGATTTTCCTTACAAATGCCAGTTTTGTCCTTACAGAGGTAGATATGCAGAATTGCTGAAAACCCACATGCGCACTCACACTGGTGATTATAGGTACATGTGCACTGAATGTCCGGCTAGATTTTTATTTAAGAGTAATCTTAACAGCCACATGTTAAAACACAAGGAACCACAGTTTAAATGTGATGCCTGCAAAAGGGCTTTTCATACTAATCTAATGTTACGGAGGCATTATGAGGCTGATCATTTGGGAATTaaaaaccatgtttgcaatatgtgtggaaaggcttttggttataGGAATACTATGATGAAACATCAGCGCCATATACATAAAAGGGAAAAATTACTTTTTGGCCGAATGCCATCTTATTTGGAAGCGGAACAAAAAGTTCATGAAGATA
Protein Sequence: LAKEISGSALLFRKTAKESEEVLRRSVKEEFVFEQQDHDYTDSFESKDTTQNWSSNEEGNSKEFKVNKREKIKQTSKVTCHVCNKVINRSYYKEHLTMHDPNHLKYVCDVCGKSFRLRCAYHNHSLRHREDFPYKCQFCPYRGRYAELLKTHMRTHTGDYRYMCTECPARFLFKSNLNSHMLKHKEPQFKCDACKRAFHTNLMLRRHYEADHLGIKNHVCNMCGKAFGYRNTMMKHQRHIHKREKLLFGRMPSYLEAEQKVHED

Sequence clustering based on sequence similarity using MMseqs2