Basic Information

Insect: Gonocerus acuteangulatus
Gene Symbol: -
Assembly: GCA_946811585.1
Location: CAMPFD010005459.1:19522-21156[+]

Transcription Factor Domain

TF Family: MH1
Domain: MH1 domain
PFAM: PF03165
TF Group: Unclassified Structure
Description: The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 0.0039 44 6.2 0.8 77 101 23 47 9 49 0.81

2 15 0.31 3.5e+03 0.1 0.1 78 96 50 68 46 75 0.81

3 15 0.0034 38 6.4 0.2 77 101 75 99 69 101 0.83

4 15 0.0025 28 6.8 0.1 77 102 101 126 97 127 0.79

5 15 0.0019 21 7.2 0.3 78 101 128 151 125 153 0.78

6 15 0.16 1.8e+03 1.0 0.1 77 96 179 198 172 204 0.77

7 15 0.32 3.6e+03 0.0 0.0 77 96 205 224 199 231 0.84

8 15 0.086 9.7e+02 1.9 0.1 86 101 241 256 227 258 0.74

9 15 0.012 1.4e+02 4.6 3.5 59 101 292 334 259 336 0.72

10 15 0.0017 19 7.4 0.1 74 102 333 361 330 362 0.80

11 15 0.0027 30 6.7 0.7 77 101 388 412 381 414 0.81

12 15 0.0016 17 7.5 0.1 78 101 415 438 410 440 0.79

13 15 1.4 1.6e+04 -2.0 0.0 78 95 441 458 436 460 0.79

14 15 0.0066 74 5.5 0.3 77 101 466 490 457 492 0.74

15 15 0.0055 61 5.7 0.1 78 101 493 516 489 518 0.78

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	0.0039	44	6.2	0.8	77	101	23	47	9	49	0.81
2	15	0.31	3.5e+03	0.1	0.1	78	96	50	68	46	75	0.81
3	15	0.0034	38	6.4	0.2	77	101	75	99	69	101	0.83
4	15	0.0025	28	6.8	0.1	77	102	101	126	97	127	0.79
5	15	0.0019	21	7.2	0.3	78	101	128	151	125	153	0.78
6	15	0.16	1.8e+03	1.0	0.1	77	96	179	198	172	204	0.77
7	15	0.32	3.6e+03	0.0	0.0	77	96	205	224	199	231	0.84
8	15	0.086	9.7e+02	1.9	0.1	86	101	241	256	227	258	0.74
9	15	0.012	1.4e+02	4.6	3.5	59	101	292	334	259	336	0.72
10	15	0.0017	19	7.4	0.1	74	102	333	361	330	362	0.80
11	15	0.0027	30	6.7	0.7	77	101	388	412	381	414	0.81
12	15	0.0016	17	7.5	0.1	78	101	415	438	410	440	0.79
13	15	1.4	1.6e+04	-2.0	0.0	78	95	441	458	436	460	0.79
14	15	0.0066	74	5.5	0.3	77	101	466	490	457	492	0.74
15	15	0.0055	61	5.7	0.1	78	101	493	516	489	518	0.78

Sequence Information

Coding Sequence: ATGGACGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCGATCCAACACAGGGACGGTATGTTGCAATCAAACACAAGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCGATCAAACACAGGGCCGGTATGTTTCAATCCAACACATGGAAGGTATGTTGCGATCCAACACAGGGACGGTATGTTGCGATCAAACACAGGGACGTTATGTTGCAATCCAACTCCAGGAAGGTATGTTGCGATCCGACACATGGAGAGTATGTTGCAATCCAACACATGGACGGTATGTTGCGATCCGACAGGGGGAGAGTATGTTGCAATCCAACACATCGAAGGTATGTTGCGATCCAACACAGGGACGGTATGTTGCAATCAAACACAAGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCGATCAAACACAGGGACGGTATGTTTCAATACAACACATGGAAGGTATGTTGCGATCCAACACATGAACGGTATGTTGCGATCCGACACATGGAGAGTATGTTGCAATCCAACTCCTGGAAGGTATGTTGCGATCCGACACATGGAGAGTATGTTGCAATCCAACACATGGACGGTATGTTGCGATCCGACAGGGGGAGAGTATGTTGCAATCCAACACATCGAAGACGGTATCTTGAGATCCGACACATGGAGTGTATGTTGCGATCCAACACATGGACGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCGATCCAACACAGGGACGGTATGTTGCAATCAAACACAAGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCAATCAAACACAAGGAAGGTATGTTGCAATCCGACACATGGAGAGTATGTTGCAATCCAACTCCTGGAAGGTATGTTGCGATCCGACACATGGAGAGTATGTTGCAATCCAACACATGGACGGTATGTTGCGATCCGACAGGGGGAGAGTATGTTGCAATCCAACACATCGAAGGTATGTTGCGATCAAACACAGGGACGGTATGTTGCAATTCATTACATTGACGGCGTGTTTCAATCCAACACATAGACGGTATCTTGAGATCCGACACATGGAGTGTATGTTGCGATCCAACACATGGACGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCGATCCAACACAGGGACGGTATGTTGCAATCAAACACAAGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCGATCAAACACAGGGACGGTATGTTGCAATCAAACACAAGGAAGGTATGTTGCAATCCAACACATGGAAGGTATGTTGCAATCCAACACATGGGGAGTATGTTGCAATCCAACACATGGACGGTGTGTTGCAATCCAACACATTGACGATATGTTTCGATCCGACACATGGGGCGTATGTTGTAATCCAACACATGGAAGGTATGTTGCGATCTAA
Protein Sequence: MDGMLQSNTWKVCCDPTQGRYVAIKHKEGMLQSNTWKVCCNPTHGRYVAIKHRAGMFQSNTWKVCCDPTQGRYVAIKHRDVMLQSNSRKVCCDPTHGEYVAIQHMDGMLRSDRGRVCCNPTHRRYVAIQHRDGMLQSNTRKVCCNPTHGRYVAIQHMEGMLRSNTGTVCFNTTHGRYVAIQHMNGMLRSDTWRVCCNPTPGRYVAIRHMESMLQSNTWTVCCDPTGGEYVAIQHIEDGILRSDTWSVCCDPTHGRYVAIQHMEGMLRSNTGTVCCNQTQGRYVAIQHMEGMLQSNTWKVCCNQTQGRYVAIRHMESMLQSNSWKVCCDPTHGEYVAIQHMDGMLRSDRGRVCCNPTHRRYVAIKHRDGMLQFITLTACFNPTHRRYLEIRHMECMLRSNTWTVCCNPTHGRYVAIQHRDGMLQSNTRKVCCNPTHGRYVAIQHMEGMLRSNTGTVCCNQTQGRYVAIQHMEGMLQSNTWGVCCNPTHGRCVAIQHIDDMFRSDTWGVCCNPTHGRYVAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -