Basic Information

Gene Symbol
gtf3a
Assembly
GCA_003055095.1
Location
NCVS01001001.1:22384-26594[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.00012 0.0092 16.1 0.1 2 23 703 724 702 724 0.97
2 17 0.03 2.3 8.5 1.0 1 19 730 748 730 750 0.93
3 17 1.4 1e+02 3.3 2.5 2 23 757 778 756 778 0.95
4 17 0.0044 0.33 11.2 5.3 3 23 787 808 786 808 0.98
5 17 0.0029 0.23 11.7 2.1 1 23 815 838 815 838 0.95
6 17 7.2e-05 0.0055 16.8 0.7 1 23 844 867 844 867 0.94
7 17 0.32 25 5.3 2.7 2 23 875 895 875 895 0.96
8 17 3.7e-07 2.8e-05 24.0 2.1 2 23 901 922 900 922 0.97
9 17 1.7e-06 0.00013 21.9 0.2 1 23 928 950 928 950 0.99
10 17 0.00042 0.033 14.3 2.4 2 23 962 984 961 984 0.95
11 17 0.006 0.46 10.7 2.5 1 23 990 1013 990 1013 0.96
12 17 0.0091 0.7 10.1 3.0 2 23 1035 1057 1034 1057 0.95
13 17 0.00063 0.048 13.8 0.9 2 23 1064 1086 1063 1086 0.96
14 17 2.9e-05 0.0022 18.0 1.0 2 23 1094 1115 1093 1115 0.96
15 17 0.00092 0.071 13.3 2.3 1 23 1121 1144 1121 1144 0.96
16 17 0.25 19 5.6 3.2 2 23 1151 1172 1150 1172 0.96
17 17 0.0073 0.56 10.5 2.6 1 23 1178 1200 1178 1200 0.98

Sequence Information

Coding Sequence
ATGAAAATGCCAAATTCTGATATGAAAAACAAAGATCataattacactgaaaaatcaTCAGATAATTATGGTCATAGCGATACCACTACTTGGCAAATCACAGAAACAAACTCAAATAAATCACTATCTACAGAATATATAAACATGGCAACTCCAAACAAAGATATAATTGGgggacaaataaaaaatataagtgaattgaaaaaaatcactccACGGGTTAAATTGATAGGAAGAGATGTTAGTAGTTTAAACGAATTAACAAAgatgaataaatcattttttgatcaAAAAGTGGTAATGGATGATCATGTTAaacaagaattaaaaaagtattgtCGTACATGTGCAGGTTCCAAATTGCCTCTAGTAGATATCTTTAGCGAAAAAGGTATTCAAATGAGGCTGAGTCAGCAAATGAAACATTTGGAAGAGATAAATCAGAACGATTGTTTATCGACCCAAATGTGTATGGATTGTATATGTGATCTTAAGAtgagttataaattttttatgcaaattaagAAAGCAGAAGTTAAATTGATATCGATACATCATTCACTGACTAATGTAGGCAACAAGAAAGTAGAATCTGGGAAACAACAAATATCAGTTGTAATAGATCATCCCCGAAATTCAGATAACGGAATACCAgctaaaaatgaagaagaaccTATTGTGTTGGTAGACGAATCTTCCGTCTTCTCTACGCAAAATTTAGATATTCCTTCTGCGAATACTATTTCAGATGTTAATGAATTAAAAGTAGAAtcagataaaattaatgaagcGGTTCGACGAAACAGCGATGACAATGAATCCATCGAAGAATTCGATCCTGATGATCCACCGTTTCATCCCGATACTTCGGATAATGCAGAATCCGAAGATATCGAGGACGGTGAACAAGCAATGCGGAAACGTTTTAAGAAGGAACAGTGTTTTAAGAAATTGACGAATCCGTTTGCTCTAAGTTCTACGCCGAGAGATGATAAGAAAGATATTAGTCAAACAATTTACAAATACGATATGGCTTTACAAgggtatataaaaataaatgaaaataaaacgttagTTTCGGGCGTAGAAGCGACAGATACCCCTAAAGATCTGAAGCAACCAAATATCCTCAAGCGAAGAATATCCGCAccgattaaaaaagaaacaaaaactgaaTCTAATGATAATATTGCTTTCATAAATTGTTCGAATCCGACGAGCGAGTTGGTCGAgccgaaaattcaaaaattaaacatttctaATCCCTTGAGCGTTACAAATGCAGAGCAAGATGGTATTATGTACGTAACTGTAAAGGGATCAAAgccaaatgaaattttattggtgAAAGTAAAGAAAATGGACAAAACCACTGACCGAAAAGACGAAAAGTTAATCGCGAAGAAAACAGTCGAACCGAAACCAATTGACAAAATGTTGAAAACACTATCGAAGGATAAAGATTCGTTTGTAGCAAAGAAACCCGATATACGCGAATTAATAATCGAGGAGCAAATAGaggaatataaaaagaaacgcgagaaaGTATTCGGGGGTCATGCGATTTTGCCGGCTATTATGAGAGAAGAATTATTGACTCCACGATTTGTGAAACAAGAATCTGACAGTGAAATAGTTAAAATGGATACTTCCAACGAGGAATCTTTATCCTTAAAAGCCGATAACGATAACTCAATTGCCGATAACGAAAACAGCTGCATTTCTATGGAGCAAGAAAGTGTAGAAGATGCTGATTTGGATGATAAATCGATTACTGACGACGAACTAATGCATGAATTGAAGGAAGAAAGTGCCGACGAAGGGACTTCTCGACCAAGAATAAGGCACAAatacgaaaaagaattttcgcaaTACAGTTCCGAGGTTAATCTCGAAAAGTTGTCTAAAATTTTGGGCGAGCCGAAGGAAAATCTGGTCGAATTTCAAGATTACTTGAGACAAAGACGAATTGTTTTGTCAAGGCTGAAAGACGAAGACATAATATCTCTGTACGATGATCGCAATAATGCTCTTCAAAAGAAAATGTTTCCAGATCTAATCGATGAAACACAACCACAGGACTACATACCTGAAGAAAATTACTTGGAATGCGATTATTGTCCAGAAACATTTGCTTCCAAGGAGGTACTCGAAGATCATCTGAAGTCACATGACTTCAAGATAATGCATTATTGCGAAGATTGCAATGAAGAATTTTCTACGAATAAAGCCAAACGCAATCACAATGTAGtatgcataaaaaaattaatctgcCGGTACTGCGATATATGTCTCGAATCGAAAGGTAAGAAACGTCAACACGAGCAGAAACACTGCGACAACATGTACGGACAATTATGTCACGTCtgcggtgaaaaattcaaacatcaCGGCACTTTAGATCAGCACGTAAAAACTCAACATAAAAGCTGGGAAAAGATATTTCAGTGTCCAAAGTGTCCCAAAAAATTCgctttcaaacaaaaattaagttttCATCTAAAGTCCGTTCACACAACTATGCGAGCGTACTTATGCGAGGACTGCGGTGCGGATTTCAAGAACCCAGCTAGCCTGAGACACCACAGAATACGAAAGCATCAGCCGGTGAACAATATTCGTGAATGCCCAGTTTGCCACAAAATGATACCATTCTATAGCTTGTCCAAACACATGCATACACATAAAGCCTATACAATTCAGTGTCCTCACTGTGAAAAGATGTTCAAGAATAGCTCAACATTGAAACAACATGTGAGGATTCATGAGGATCAGCGTCAGTACCGGTGCGATACCTGTGGTGTTGGTTTCAATCGCCGTGATGGTCTCAGATTGCATATGAGAGTTCATGAGAAAAGCGACAGTCGGGGTTTAAAAGAATGCTCATGCCAAGTTTGCGGTGAGAAATTCCCAAATCATTCAACTCTTGTTATTCACAGAAATCGAGTTCACAAGGATGGAAGACAATATACATGTCACATTTGTAACAGATCTATGATATCAACTAGATCGTTGGAGTGGCATATGTCCCATATTCACAACGAATCACTTCCTGGAATTGTCAAAGATGATTCAGATGGATCCCAAGACAAGAAACGAGTGTCTTGTTACCACTGTAACAAGACTTTCAAAACAGAAATGATATTGAGGACTCACATAAAGAACACTCATATGCACAAAGATCCTATGAAATGTTTAGATTGTGAACTAACGTTTACGTCAGAGGTCAGATTACGACACCATATGATGGTTGTTCATAACCGTTTAGAAGGCACCTTACCCTGTCCACATTGTCCTAAACGGTTTGTTAATCAGCTGAGACTAAAGACTCATATGATATCTCATTCAGAGGAGAGGCCATATACTTGTGAGATCTGTggttttaatttgaaaacaaagaTACAACTCATCAAGCATCATCAAAATAGGCACAGCGATGAGAGACCATTGCAATGCAGGTATTGTCCATGGAGGTGTAAGCAAGTCAGTGCATTAGTGTGCCACGAGAGAACTCACACCAACGAGCGACCATACTCTTGCAGTGTTTGTAGACAACGTTTCAAATATTTGGGTGATAAGAACAAACACGAACGAAGGCACGAGAGTTTAGGTGGCTCAGGCTTTAAGCGAATAGCACCTGGTCGCAATATGAAGCAACCTAAAGTGCAAGATGAAGATACTACAAGTTCAGAGCAAGATCGAGAAGCTCTGCAAAAAGTAGAAGCTCAACTTGCGGAAGAGCAGTACGAGGAAGGTAATACCGAAGacttcgacgataaatttgaGAATGCTCAAATTGTTAAATTGGAAGAACAAGAAATTGGCGAATATGAAGAGGTTTATAAacagGAATATGAAGAAACATCTAGGGAAGCTTCGGAAGCGGCTGAGGTCATTATGAACATGGAGGATACAACTGTTTATACAGAAGAAGTCACCGCTGACAATATAGAATCCGCTGAAATCATGACGGACGAAATGATGGCAACAGAAATATTCCAATCTGGTACTGTCGTTCACCTGCAGCAGCAGGACGACAACGGCAAGATTCAAGTTATTCCTGTGATGCTGTCGCTGCCCGATCTTTCAGACACTAGTGCAGAGGTTAATCTCGCCACGGCATCTATTATGTACAATAATTga
Protein Sequence
MKMPNSDMKNKDHNYTEKSSDNYGHSDTTTWQITETNSNKSLSTEYINMATPNKDIIGGQIKNISELKKITPRVKLIGRDVSSLNELTKMNKSFFDQKVVMDDHVKQELKKYCRTCAGSKLPLVDIFSEKGIQMRLSQQMKHLEEINQNDCLSTQMCMDCICDLKMSYKFFMQIKKAEVKLISIHHSLTNVGNKKVESGKQQISVVIDHPRNSDNGIPAKNEEEPIVLVDESSVFSTQNLDIPSANTISDVNELKVESDKINEAVRRNSDDNESIEEFDPDDPPFHPDTSDNAESEDIEDGEQAMRKRFKKEQCFKKLTNPFALSSTPRDDKKDISQTIYKYDMALQGYIKINENKTLVSGVEATDTPKDLKQPNILKRRISAPIKKETKTESNDNIAFINCSNPTSELVEPKIQKLNISNPLSVTNAEQDGIMYVTVKGSKPNEILLVKVKKMDKTTDRKDEKLIAKKTVEPKPIDKMLKTLSKDKDSFVAKKPDIRELIIEEQIEEYKKKREKVFGGHAILPAIMREELLTPRFVKQESDSEIVKMDTSNEESLSLKADNDNSIADNENSCISMEQESVEDADLDDKSITDDELMHELKEESADEGTSRPRIRHKYEKEFSQYSSEVNLEKLSKILGEPKENLVEFQDYLRQRRIVLSRLKDEDIISLYDDRNNALQKKMFPDLIDETQPQDYIPEENYLECDYCPETFASKEVLEDHLKSHDFKIMHYCEDCNEEFSTNKAKRNHNVVCIKKLICRYCDICLESKGKKRQHEQKHCDNMYGQLCHVCGEKFKHHGTLDQHVKTQHKSWEKIFQCPKCPKKFAFKQKLSFHLKSVHTTMRAYLCEDCGADFKNPASLRHHRIRKHQPVNNIRECPVCHKMIPFYSLSKHMHTHKAYTIQCPHCEKMFKNSSTLKQHVRIHEDQRQYRCDTCGVGFNRRDGLRLHMRVHEKSDSRGLKECSCQVCGEKFPNHSTLVIHRNRVHKDGRQYTCHICNRSMISTRSLEWHMSHIHNESLPGIVKDDSDGSQDKKRVSCYHCNKTFKTEMILRTHIKNTHMHKDPMKCLDCELTFTSEVRLRHHMMVVHNRLEGTLPCPHCPKRFVNQLRLKTHMISHSEERPYTCEICGFNLKTKIQLIKHHQNRHSDERPLQCRYCPWRCKQVSALVCHERTHTNERPYSCSVCRQRFKYLGDKNKHERRHESLGGSGFKRIAPGRNMKQPKVQDEDTTSSEQDREALQKVEAQLAEEQYEEGNTEDFDDKFENAQIVKLEEQEIGEYEEVYKQEYEETSREASEAAEVIMNMEDTTVYTEEVTADNIESAEIMTDEMMATEIFQSGTVVHLQQQDDNGKIQVIPVMLSLPDLSDTSAEVNLATASIMYNN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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