Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.022 2.5 9.8 0.6 1 20 144 163 144 166 0.93

2 5 0.00028 0.033 15.7 3.3 1 23 178 200 178 200 0.98

3 5 1.6e-05 0.0018 19.6 2.2 2 23 207 228 206 228 0.97

4 5 1.9e-05 0.0022 19.4 0.9 1 23 234 256 234 256 0.98

5 5 3.7e-05 0.0043 18.5 1.3 1 21 262 282 262 285 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.022	2.5	9.8	0.6	1	20	144	163	144	166	0.93
2	5	0.00028	0.033	15.7	3.3	1	23	178	200	178	200	0.98
3	5	1.6e-05	0.0018	19.6	2.2	2	23	207	228	206	228	0.97
4	5	1.9e-05	0.0022	19.4	0.9	1	23	234	256	234	256	0.98
5	5	3.7e-05	0.0043	18.5	1.3	1	21	262	282	262	285	0.89

Coding Sequence: ATGTCTCCAGCTACCAGGCGCAGTGGAAGGAGCACAACTACTGCCAAAATAAtaaccaaagaaaaaaatcccaaGAAGGTGAAGAAGGAAAATAATAAGGAAACCAGGACACTATCATCGAGGGGTGCTGCTGTAAAATCGGAATCCAAAGTTAGTGGAGAGAAACCCAAGTGCAGGAAAGTCAAATCGGAACCAAATGACATTAAAGGCGAACCTAAAGAAGTATCACTTGAAGGAATCCCCGCTCTACGTACTCGTAATGTGCGCGTTAAGGAAGAATGCAAGGAAACGAATAGTAACGCCAAAAAAGAACATAAATTGATATTTGATCCAGTAGTCGTAAAAAGTGATGGTGAGATATTCGATTTAGTCTCCATTCCAGAGTTTCCTGACATTAAACTTGAAGTTATGAAACCAGGCAAGCACCCGTATCAATGCTATAAATGTTACATGGGCTTCCGTACAAAGGAAGCTTATGATGCCCACACTCCCGTTCACATCCTCCGCAAACAGAAACGTCCCCCATATAGATTCCGCTGCAATGTTTGTCTCAAGGAGTTCTACAAACTGTGCGACCTCGAAAGGCACACTAGGGTTCATACTGGGGAGAAGCCCTGGGTGTGTGACATTTGCCACAACAGGTTCCAACAGTCATACAACCTGAAGAAACACCTGCTCACCCACGTCGATCTCAAGCCTTTCCAGTGCAGGTACTGCAAAAAGCAGTTCGGAAGGGCCGACGTGCTGACTAGGCATCTCCTGATCCACTCCAAAGACAAACCGTTCACGTGTTCCATCTGCCAGAAAGGTTTTATCCGTCAATCACAATTGTACACGCACTTCGTGAACAATCATCCTGAGGAAAAGTTTGTCAAGTCTGAACCCGAAGGCCTCTTAGAGTGTGAGGTCATTGTCAAGGAGGATGTCAAAGGGAGTGTCCGGACGAAGAGTGAGGTAGACGATGAGGACAATATCATGTGTGGAGCGTATTGA
Protein Sequence: MSPATRRSGRSTTTAKIITKEKNPKKVKKENNKETRTLSSRGAAVKSESKVSGEKPKCRKVKSEPNDIKGEPKEVSLEGIPALRTRNVRVKEECKETNSNAKKEHKLIFDPVVVKSDGEIFDLVSIPEFPDIKLEVMKPGKHPYQCYKCYMGFRTKEAYDAHTPVHILRKQKRPPYRFRCNVCLKEFYKLCDLERHTRVHTGEKPWVCDICHNRFQQSYNLKKHLLTHVDLKPFQCRYCKKQFGRADVLTRHLLIHSKDKPFTCSICQKGFIRQSQLYTHFVNNHPEEKFVKSEPEGLLECEVIVKEDVKGSVRTKSEVDDEDNIMCGAY

Sequence clustering based on sequence similarity using MMseqs2