Basic Information

Insect: Gonatopus flavifemur
Gene Symbol: topi
Assembly: GCA_018340375.1
Location: Contig1:64165171-64170024[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 16 0.036 5 8.1 2.0 1 23 508 530 508 530 0.95

2 16 0.14 19 6.3 2.6 2 23 537 559 536 559 0.95

3 16 0.0027 0.37 11.7 0.4 2 21 566 585 565 586 0.92

4 16 3.2e-05 0.0045 17.7 0.8 1 23 593 615 593 615 0.97

5 16 3.2e-07 4.4e-05 24.0 2.7 1 23 621 643 621 643 0.98

6 16 0.11 15 6.6 0.3 2 23 655 676 654 676 0.92

7 16 0.06 8.3 7.4 7.3 1 23 692 714 692 714 0.97

8 16 0.018 2.4 9.1 1.2 1 23 720 742 720 742 0.95

9 16 0.12 16 6.5 1.6 1 23 752 775 752 775 0.95

10 16 0.13 19 6.3 0.0 1 21 789 809 789 810 0.91

11 16 0.0018 0.25 12.2 0.3 1 23 815 837 815 837 0.98

12 16 2.2e-06 0.0003 21.4 3.1 1 23 843 865 843 865 0.98

13 16 0.00016 0.022 15.5 0.5 1 23 871 894 871 894 0.97

14 16 0.053 7.4 7.6 0.7 1 23 900 922 900 922 0.88

15 16 3.5e-07 4.9e-05 23.9 2.2 1 23 928 950 928 950 0.99

16 16 9.2e-06 0.0013 19.4 5.1 1 23 956 979 956 979 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	16	0.036	5	8.1	2.0	1	23	508	530	508	530	0.95
2	16	0.14	19	6.3	2.6	2	23	537	559	536	559	0.95
3	16	0.0027	0.37	11.7	0.4	2	21	566	585	565	586	0.92
4	16	3.2e-05	0.0045	17.7	0.8	1	23	593	615	593	615	0.97
5	16	3.2e-07	4.4e-05	24.0	2.7	1	23	621	643	621	643	0.98
6	16	0.11	15	6.6	0.3	2	23	655	676	654	676	0.92
7	16	0.06	8.3	7.4	7.3	1	23	692	714	692	714	0.97
8	16	0.018	2.4	9.1	1.2	1	23	720	742	720	742	0.95
9	16	0.12	16	6.5	1.6	1	23	752	775	752	775	0.95
10	16	0.13	19	6.3	0.0	1	21	789	809	789	810	0.91
11	16	0.0018	0.25	12.2	0.3	1	23	815	837	815	837	0.98
12	16	2.2e-06	0.0003	21.4	3.1	1	23	843	865	843	865	0.98
13	16	0.00016	0.022	15.5	0.5	1	23	871	894	871	894	0.97
14	16	0.053	7.4	7.6	0.7	1	23	900	922	900	922	0.88
15	16	3.5e-07	4.9e-05	23.9	2.2	1	23	928	950	928	950	0.99
16	16	9.2e-06	0.0013	19.4	5.1	1	23	956	979	956	979	0.96

Sequence Information

Coding Sequence: ATGGAAGTAACAGAAAACTTGGAAGATATTTTGAAAAGGCAAAGTGATAAACTTGAAACACTTCATGTGGCATCACAAATTTTACAAAGTAAACTTGTTTTAAAAGTTGTGTACATCCATGAAATTTCTCTTTTCATATTTGACTATATAGGTAAAAACAGCTTGAAAGAAGAACTCTATGATATTCGTTCGTCAGTAACACAGTTGTCGGATTCCATGGAAAGTCTACGGAACCATCTGAATATCATGAAACAACAGAATGAACAATGTCGGGTAATGTTGGCATCAATTCAAGAATTGGATGAAAAGATATTGGATATGCAAGCGAATATACCACCTAAATTGATTCAAGATTATACATACACACACATGCAATCGTTAAGCAAATCCATGCCCACGAGCGAAGACTTGAATTTTTATTCAACTCCGATTGCCGACGATAAGGAGAATTTCCTCCTTGGAAATTCTCCTTTCTACACTCGCATAGATACAGGCGAAACTCCTCTAAAAGATTGTAAAAAAATTTTGTTCGACGATTCTCAAGTTTATCCCTCCATACAAAACATTACGGAAGAAGAATTCTCTAAAATTCCAAAATATATCATAGGAAGACAATCTTTGCAGTCCGTGAATGATTTCATCAAAGTCATTAATCAAATTTTAAAAGCAAAATATACACTTCTGTCACTAGGAAAATCAAATGCGAGGAAAAAAAATGAACTTGATGTGTTTTTGAATTATCAAAGACAACAGGCCATTCTTGAAAAAGAAAGTGCAATCCAATTGAATAACACCGAAATGTTTGAAGTTGAATCTCTTGGTACATTGAGCGATCAAGATATTGGAGATTTTGATGAATCTATGATTTGGTCTCAAGAGGAAGCATTGTCTTCGAATGAAGTACTAGAACCAAATTTAAATGAACCAGATTTGAATTCGGAAAATCAATCACTAATTTTATTATGCCGGTTATGCGCGGGGCAAGTTGTTGATCCAATTTTTATATACTCAGAATTTGGACAATCCATGAAGTTAGAGCATAAAATAAACACTTGTTTGAGCATCAAGATTAGGAAAACAGATCCATTGCCGAAACAACTTTGTGCTACTTGCGTGGAAAAAGTCAACTGGTGCGACGCTTTTGACAATCAATGTATCCAAGCGGAAGAAATTCTCACAACTATGATCAAGAAAAAACGTACATTCGAATTGACGAATACAAACGATAAATCAGATTCATGTCCTTTGTGTATCGATGGCCATATGAATCTATATAACGAGAATACCAAAAATTCGGAATTATACGATAGCGATATTATTTTGGACAGTAGCGACGAAGAAAGAATATATTTAGACCTGAAAATTGACGAAAAAGCGGTAGACAATAGATCCGTTGTGTTGAGTTGTCTAGGAGATGATCAAAGATACTTGAAATGTGGTGCCTGTATGAATCTCTATCACACCAAAGAAACATTTGATCAACATAAATGTAAACCAAGTATTCAGAATACTTCGAAACCTTACAAGTGTTCAGTTTGCAATACTATTTTCACTTTTGAAGAACGGTTGAATTTTCATATGCAGTTTCATAAAGGGTTCAAAACCTTATACTGTGACACATGCAAACTCACATTCAACAAAGAATTGAAACTTTTCTATCATTACAAGAGATATCATTGCCAAGAATCCACTGTATCTTGTTTACAATGTGGAAAACTATTTGAAAATCAAAAAGAATTGAAAATTCATGTATGTATAGATGGCAAAGTAAGACCTCACGTTTGCGAAGTTTGTAACAAAGGATTTTCAGATGGGTATACATTGAAGAGGCACGTAGTTACACATCTGCCTGAGAAACCGTACAAATGTTCTCAATGTCCCAAAAGTTTTACGCAAAAATCAAGATTGAATAAACACATCTCGAGTCATGGGGTAGTCATTGAAAATAATCAGACCATGTGGAAATGTATCCAATGCGGCGAGACGTTTGTCACTTGCGAAGAAGCGGACGCCCATTACAAGATTCACGAAAATAAAGTCAATATCATTGAAGAACTTTCCGCATCTAAAGTCTATCATTGTGAATTTTGTAACTCTCATTTCACCGACACGTCGTTTTTGAAGCAACATCAAACTTCGCATACGGTAGAAAAACCTTATAATTGTAACATATGCGACACACATTATAAATCATTTTCCGAAGCTGTATTACATTGGAAAGAACATCCAAGAGTTTTCAAAGTATTGACCACGTTCTTTTGCGATATATGCGATCGAGATATGAAAGAATTGTCTTTGCTTTACAAACATAAGCAGAAAAAACATCAATACGTTGCGAGAAAGTCGGAAACGGGAGAATCGAAGTTCATATGCGAGCTTTGTGGAAATATATTTGATAATAAAGAAGGTATTCAAGATCACGGACGTGATCAATGTTCTAAATTCCCATGCGATATATGTGGACATTTATTACCAACTGAAAATTCTTTGAACGCTCACAAAAGACGACACAGTGGTTTGAGACCCTACGTTTGTAACATTTGTGGAAAAAGTTATACTCAATCCAGTCACATGTGGACTCACAAGAGATTTCATATGGGAGTTAAACCTTACGCTTGCGAATATTGCGATCAGAAATTTACGATAAAACCTGATCTAGCTGATCATACCAGGAAAAAGCATACCCGGGAAAGACCTTTCAAATGCGATGTTTGTAACAAAGCTTTTCTGACAGGATCCGTGTTTTATCAACACAGATTGATTCATCGCGGAGATCGTAGATATAAATGTCATTATTGTGAAAAAGCGTTCACAAGGACAGAAGCTTTGAATAATCATATTAAAATTCATACAGGAGAGAAACCCCACGCTTGTGATATCTGTGGAAGATGTTTTAGGCAAAAAGGTGACATGAGGAAGCACAGAAAAACTCAGCATAGCATTCTTGTGCAAGAACCACAACAGCTTTGCTCCAAATGA
Protein Sequence: MEVTENLEDILKRQSDKLETLHVASQILQSKLVLKVVYIHEISLFIFDYIGKNSLKEELYDIRSSVTQLSDSMESLRNHLNIMKQQNEQCRVMLASIQELDEKILDMQANIPPKLIQDYTYTHMQSLSKSMPTSEDLNFYSTPIADDKENFLLGNSPFYTRIDTGETPLKDCKKILFDDSQVYPSIQNITEEEFSKIPKYIIGRQSLQSVNDFIKVINQILKAKYTLLSLGKSNARKKNELDVFLNYQRQQAILEKESAIQLNNTEMFEVESLGTLSDQDIGDFDESMIWSQEEALSSNEVLEPNLNEPDLNSENQSLILLCRLCAGQVVDPIFIYSEFGQSMKLEHKINTCLSIKIRKTDPLPKQLCATCVEKVNWCDAFDNQCIQAEEILTTMIKKKRTFELTNTNDKSDSCPLCIDGHMNLYNENTKNSELYDSDIILDSSDEERIYLDLKIDEKAVDNRSVVLSCLGDDQRYLKCGACMNLYHTKETFDQHKCKPSIQNTSKPYKCSVCNTIFTFEERLNFHMQFHKGFKTLYCDTCKLTFNKELKLFYHYKRYHCQESTVSCLQCGKLFENQKELKIHVCIDGKVRPHVCEVCNKGFSDGYTLKRHVVTHLPEKPYKCSQCPKSFTQKSRLNKHISSHGVVIENNQTMWKCIQCGETFVTCEEADAHYKIHENKVNIIEELSASKVYHCEFCNSHFTDTSFLKQHQTSHTVEKPYNCNICDTHYKSFSEAVLHWKEHPRVFKVLTTFFCDICDRDMKELSLLYKHKQKKHQYVARKSETGESKFICELCGNIFDNKEGIQDHGRDQCSKFPCDICGHLLPTENSLNAHKRRHSGLRPYVCNICGKSYTQSSHMWTHKRFHMGVKPYACEYCDQKFTIKPDLADHTRKKHTRERPFKCDVCNKAFLTGSVFYQHRLIHRGDRRYKCHYCEKAFTRTEALNNHIKIHTGEKPHACDICGRCFRQKGDMRKHRKTQHSILVQEPQQLCSK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -