Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 4.7e-05 0.0027 18.3 0.7 1 20 33 52 33 55 0.93

2 6 0.00023 0.013 16.1 4.6 1 23 61 83 61 83 0.97

3 6 0.00012 0.0068 17.0 1.3 3 23 91 111 90 111 0.98

4 6 3.1e-05 0.0017 18.9 0.6 1 23 116 140 116 140 0.98

5 6 8.7e-07 5e-05 23.7 2.0 1 23 146 168 146 168 0.97

6 6 0.39 22 5.9 4.2 1 23 174 197 174 197 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	4.7e-05	0.0027	18.3	0.7	1	20	33	52	33	55	0.93
2	6	0.00023	0.013	16.1	4.6	1	23	61	83	61	83	0.97
3	6	0.00012	0.0068	17.0	1.3	3	23	91	111	90	111	0.98
4	6	3.1e-05	0.0017	18.9	0.6	1	23	116	140	116	140	0.98
5	6	8.7e-07	5e-05	23.7	2.0	1	23	146	168	146	168	0.97
6	6	0.39	22	5.9	4.2	1	23	174	197	174	197	0.95

Coding Sequence: AACACACAAAAAAAAACTCGTATATCGTGTCAATTAACCGATTTACAAAAATTCCTACATAGAAATCATCTGGTTCGACACGATAACGCAAAACCATTCTATTGCAACGATTGTGATCTTCGATTTGTCACCAAGTCTGCACTAAATTTGCATACACCAAAACATTCGACCGAAACGCCACATATGTGCTCGGATTGTGGTAAAAGTTTCAAATGGAAACATGGTCTCCATAGTCATATGATCGTTCATGCCAAAGAGAAGAAATTACTGTGCGATGAGTGTGGCTATAGTACGAGCCATTTGAAAACGTTGCGGGCACATCAGCTCAGCCATACGGGTCATGCATTTCGATGTCCAACACCAAATTGTACGTACACATCGAGGCGCaaagagaacctgaaaatacacattgccacgcatcgtaatgaaacgccattcgtttgcgaagtatgcggtcatcgttttaGCCAAAATAAAAATCTGAAGCGTCACGCTCAATTGCATATCTCGAAAAACATTCACAAGTGTCCGCATTGTTCGTTCAGTAATTATCGCACCGATAAACTGAAAGAACACATTGTACGGCTACATACCGAGAAGCCACTTCAATTAGAGCTACCCGAAAATGTGCATAGTGCCTTAGACGCTGAACCACCTCCTACGTATGCAGTTactgttgtgactgatgaaccacaaaaaccaattgtagcagcagcagcagcagtagtgaaacgaaaagccaccaccaacatcgttgttggtaaGGAAAAGAATAAAAAACGGCGCAACGGTTTGACAGTGAAAAAATTGCATGAACTACGGCCGAAGCCAGCAACAGCTGTAGAAGCTGCTAGTACTACAACAAAACTGCAGCTAAATGTATCTTGA
Protein Sequence: NTQKKTRISCQLTDLQKFLHRNHLVRHDNAKPFYCNDCDLRFVTKSALNLHTPKHSTETPHMCSDCGKSFKWKHGLHSHMIVHAKEKKLLCDECGYSTSHLKTLRAHQLSHTGHAFRCPTPNCTYTSRRKENLKIHIATHRNETPFVCEVCGHRFSQNKNLKRHAQLHISKNIHKCPHCSFSNYRTDKLKEHIVRLHTEKPLQLELPENVHSALDAEPPPTYAVTVVTDEPQKPIVAAAAAVVKRKATTNIVVGKEKNKKRRNGLTVKKLHELRPKPATAVEAASTTTKLQLNVS

Sequence clustering based on sequence similarity using MMseqs2