Basic Information

Gene Symbol
-
Assembly
GCA_029298725.1
Location
CM055513.1:8789890-8791453[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 6.2 4.9e+02 1.9 0.2 3 21 47 65 45 66 0.91
2 11 0.0013 0.1 13.5 2.3 2 23 157 179 156 179 0.94
3 11 2.6e-05 0.0021 18.8 0.3 1 23 185 207 185 207 0.98
4 11 3.9 3.1e+02 2.5 2.6 1 23 213 235 213 235 0.79
5 11 1.4e-06 0.00011 22.8 1.5 1 23 241 263 241 263 0.97
6 11 3.5e-06 0.00028 21.5 1.3 1 23 272 294 272 294 0.98
7 11 1.1e-07 9e-06 26.2 0.4 1 23 300 322 300 322 0.99
8 11 2.4e-05 0.0019 18.9 0.6 1 23 328 350 328 350 0.96
9 11 3.4e-05 0.0027 18.4 3.3 1 23 356 378 356 378 0.98
10 11 7e-05 0.0055 17.4 5.1 1 23 384 406 384 406 0.98
11 11 0.0001 0.008 16.9 8.4 1 23 412 435 412 435 0.98

Sequence Information

Coding Sequence
ATGGAGAACCGTTGTCGTCTATGCGCCGAACTGGGCGCCGAGTACTACAACGCGCTTGAAGATCTGGATTTAATAATTCGAATTTTCCAGCTTTTTAACGTAAAAATAAGCAACGAAGACAAACTTCCGACCACGATATGTCAGCTTTGTGCCGAAACGGTCAAACACACGTGGGAATTCAGTCAGCACGTCCAACAATCACAGGAAGTTTTAAACAACATTCTTGTagaaatcacaaaaaatgaGGAGGTTAGAATACAACACAAACCTGTGGTTGAAGACATCAAACCTTCAACCACTGACATCCTCACTACGGTGAAAAAAGAAGAATTATCTCAGAAaccagaaaaaaacaaaaagaacagGCCTAAAAAAGAAAGTGATTCAGAGTTGAGCGACGCTGAACTCAACGACGACGGAACCGTCACCCCCAAAACAGAGCTTTTTGGTTGGCACACTTATCCATGGACATGTTGTGACTGTCAGTTAAATTTTACCAATTCTGAGGATTTGCGAGAGCATCATGCATCAATCCATGGCCAAGCTCCTTCTTACCCTTGTGCAGACTGCCCAAAAGTCTATACAAAATACAGTACATTTTTAACACATGTGAGAGTTCATCGAACAAAATTACGCTTCTGTTGCGACATTTGCGGGAAGTGGTTCCTGACAGTTCAAACCCAGAAAAAGCACAGGAATGAACATGGAGATGAAAGACCCCATTCTTGTAACACCTGTGGGAAAAGTTTCCGAATGCAATCAGCTTTAATGGTGCACGCCAGATCTCATTTACCGGCGGAGTTGAAAAACAAGCACCAATGCGACCAGTGCCCCAAAAGatttggAACGAAGCCGAACCTGATGGCCCACAAACGCATCCACGCGGGCGTCCGCGACTACACCTGCGATCAATGTGGGAAAAGCTTCGTCCAAAAAGGCAACCTCGACAACCACCTCATTACCCACACCGCCGCCCGTCCCTTCGTATGTACAACATGTGGAAAAGCATTCAAAACTTTGGTCCGCCTCCGAAAGCATGGTTCAGTCCATTCCGGTCTTAAGCCCCACCAATGTGATGTTTGTGGGCGCCAGTTTCGCGAACGAGGGACTCTTAAAGAGCACCATCGGATCCATACCGGTGCCATGCCTTTTACATGCGAGTTCTGTGGAAAATGTTTTCGGTTTAAAGGAGTACTAACAACACATCGGAGACAACACACCGGGGAAAGACCGTACTCCTGCCATGAATGTCAACATCATTTTACAAATTGGCCAAATTACAATAAGCATATGAAGAGGCGACATGGGATCAATACGAGTGTTACTGTAAGGAAGCCTCAAACTATTCCGCCGACGGGAATGCCACATCGAAATCCACCGGGAACAGTACTGGCACCTCCGCAACCGATTGCAATAACTGAAAGTTTTGTGGAGACTCCAGCGTCGTTTTACCCGGTTTTGAGTTTATATAATTTGCCAGAAGAATTATTGCAGCAGAGGGTTTGA
Protein Sequence
MENRCRLCAELGAEYYNALEDLDLIIRIFQLFNVKISNEDKLPTTICQLCAETVKHTWEFSQHVQQSQEVLNNILVEITKNEEVRIQHKPVVEDIKPSTTDILTTVKKEELSQKPEKNKKNRPKKESDSELSDAELNDDGTVTPKTELFGWHTYPWTCCDCQLNFTNSEDLREHHASIHGQAPSYPCADCPKVYTKYSTFLTHVRVHRTKLRFCCDICGKWFLTVQTQKKHRNEHGDERPHSCNTCGKSFRMQSALMVHARSHLPAELKNKHQCDQCPKRFGTKPNLMAHKRIHAGVRDYTCDQCGKSFVQKGNLDNHLITHTAARPFVCTTCGKAFKTLVRLRKHGSVHSGLKPHQCDVCGRQFRERGTLKEHHRIHTGAMPFTCEFCGKCFRFKGVLTTHRRQHTGERPYSCHECQHHFTNWPNYNKHMKRRHGINTSVTVRKPQTIPPTGMPHRNPPGTVLAPPQPIAITESFVETPASFYPVLSLYNLPEELLQQRV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00167816;
90% Identity
iTF_00415345;
80% Identity
-