Basic Information

Gene Symbol
-
Assembly
GCA_949316385.1
Location
OX438680.1:10469347-10473567[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 4.7e-06 0.00048 21.5 0.7 3 23 48 68 46 68 0.96
2 10 0.49 50 5.7 1.5 2 23 74 96 73 96 0.92
3 10 2.4e-05 0.0025 19.2 1.5 1 23 102 124 102 124 0.97
4 10 0.00034 0.034 15.6 0.7 2 21 126 145 125 146 0.94
5 10 4e-06 0.00041 21.7 0.2 2 23 157 178 156 178 0.97
6 10 6.8e-06 0.00069 21.0 4.5 1 23 184 206 184 206 0.97
7 10 2.5e-07 2.5e-05 25.5 0.5 1 23 212 234 212 234 0.98
8 10 3.9e-06 0.00039 21.8 4.4 1 23 240 262 240 262 0.97
9 10 7e-06 0.00071 20.9 1.9 2 23 269 290 268 290 0.97
10 10 0.00032 0.033 15.7 4.0 1 23 296 319 296 319 0.93

Sequence Information

Coding Sequence
ATGGTAAGAATTGCCAAGCTTAGAGGCAGTAGACAGGGCActttgctcgcagaacagatggctgatGCAGTCGAAAGGTTCagaagtggcgaccgcgtaccggaagacgtagcgttggaaggcgtcccacaagAGTTGGACTGCGAGATTTGTGGAAAACATTACACAGTTTACGCCAACCTCCAACGGCACTTACAATCCCATTCAGCAAACGCTGTACAATGCAATCAGTGCAATAGACAATTTCTCAACAAACTACGCTTAGACACACATATTTTTACCCGCCACACTCTCGTAACCCCATACTCCTGTGAGCAATGCCCAGAGAAATTTAAATCGAAATATCTATTAAAGGAGCATAAAAAAGCACATTTGCAATGCTCCAAATGTTTTCTAAGTTTCACAGCCAAGCGCAACCTGGAGAGACATATCCAAAATGACTGCAACAAAACTTCTGACGGTCCTATCCAATGTAAAATTTGCGATAAGGTCTTCGAAAATGAgcctttattaaaatatcatatGAAGGAACATGATAGCGAACGGCCGTTTGACTGCGAAGAATGTTCCACGGCTTTTAAGCATAAGAGTACGTTGACACGTCATATGCACGTCCATACTGGGATTAGGCCATATCCTTGCCCTCACTGTGGCAAGACTTTCACCAGTTCTGGCTTGTTAAAGCCTCATTTACGGGTCCATACTGGCGAAAAACCTTACTCCTGCGAACTTTGTGACAAAAAATTTGCTCACAAACATAATATGCAAAGACACATGCTAGGGCATGAGAAAATTAAGCACACTGTGTGCGATATCTGTCATAAAGGGTTTCCTAGAGAGAGCAGATTGAAATATCACATGAAAACCCATGTCAATGAGAAGTATTTCTTGTGTAAAGTATGTCCTAAACGGTTTTCTCATAAGCAGAATGTTGTGAGACATTATACTAGGAAGCATCCGGGACAAACGTATCAGTGTACAGACACGGATGCGTCTGTCGCGGCGAAAGTATGGGACACGATGAAAAAGAGATTTTGTGACGAAGAAACTGAGGAGATTCTGGGCTGA
Protein Sequence
MVRIAKLRGSRQGTLLAEQMADAVERFRSGDRVPEDVALEGVPQELDCEICGKHYTVYANLQRHLQSHSANAVQCNQCNRQFLNKLRLDTHIFTRHTLVTPYSCEQCPEKFKSKYLLKEHKKAHLQCSKCFLSFTAKRNLERHIQNDCNKTSDGPIQCKICDKVFENEPLLKYHMKEHDSERPFDCEECSTAFKHKSTLTRHMHVHTGIRPYPCPHCGKTFTSSGLLKPHLRVHTGEKPYSCELCDKKFAHKHNMQRHMLGHEKIKHTVCDICHKGFPRESRLKYHMKTHVNEKYFLCKVCPKRFSHKQNVVRHYTRKHPGQTYQCTDTDASVAAKVWDTMKKRFCDEETEEILG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00123586;
90% Identity
-
80% Identity
-