Gspa022506.1
Basic Information
- Insect
- Globia sparganii
- Gene Symbol
- Runx1
- Assembly
- GCA_949316385.1
- Location
- OX438669.1:8393072-8394129[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 4.9e-52 3.8e-48 163.4 0.0 4 98 45 139 42 140 0.96
Sequence Information
- Coding Sequence
- ATGCATTTATCGAGTGAAGTGAGTTCGACGACTAGCGGACTAGGCCATGAGGCACCGTCGTCGAGCTATGGAGGCTCGTTGCCGAGTCAGCCGCTGACGGCGGAGCTACTCGCTGAGAGGACCTTGGAAGGTCTCTTGGCGGATCATCCTGGAGAGTTGGTGAAGACTGGCTGTCCTCATGTGGTGTGCACAGTACTACCCCCCCATTGGCGGTCAAACAAGACCCTCCCAATGGCCTTCAAAGTGGTGGCTCTAGGGGAGGTGGGGGACGGTACCCTGGTCACCGTCAGAGCTGGCAACGACGAGAACTGTTCTGCGGAGTTGAGGAACTGCACAGCGGTGATGAAGAACCAGGTCGCCAAGTTCAATGACTTGAGATTCGTTGGGAGGAGCGGGAGAGGTGAGTTTTTGAGACTTAGGTACTAA
- Protein Sequence
- MHLSSEVSSTTSGLGHEAPSSSYGGSLPSQPLTAELLAERTLEGLLADHPGELVKTGCPHVVCTVLPPHWRSNKTLPMAFKVVALGEVGDGTLVTVRAGNDENCSAELRNCTAVMKNQVAKFNDLRFVGRSGRGEFLRLRY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01029928;
- 90% Identity
- iTF_00622585; iTF_01180103; iTF_01029928; iTF_00274221; iTF_00839214; iTF_01119055; iTF_00039568; iTF_00300945; iTF_01084018; iTF_01546418; iTF_01542732; iTF_01544656; iTF_01025747; iTF_00040568; iTF_00374944;
- 80% Identity
- iTF_01029928;