Basic Information

Gene Symbol
-
Assembly
GCA_951217055.1
Location
OX578277.1:5191822-5199859[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.031 5.2 9.3 0.5 1 23 138 161 138 161 0.93
2 18 0.016 2.7 10.2 1.6 1 23 167 190 167 190 0.93
3 18 0.0017 0.28 13.3 5.3 1 23 196 218 196 218 0.98
4 18 0.0096 1.6 10.9 3.9 1 23 226 248 226 248 0.96
5 18 0.00029 0.049 15.7 4.4 1 23 254 277 254 277 0.98
6 18 0.083 14 8.0 3.4 1 23 283 306 283 306 0.97
7 18 3.2e-05 0.0053 18.7 2.7 1 23 312 335 312 335 0.98
8 18 0.0019 0.31 13.2 1.7 1 23 341 364 341 364 0.97
9 18 0.00012 0.02 16.9 0.3 1 23 370 393 370 393 0.97
10 18 0.0053 0.89 11.7 5.5 1 23 399 422 399 422 0.97
11 18 0.0019 0.31 13.2 1.7 1 23 428 451 428 451 0.97
12 18 0.00054 0.089 14.9 0.7 1 23 457 480 457 480 0.97
13 18 0.00013 0.022 16.8 1.0 1 23 486 509 486 509 0.96
14 18 0.00078 0.13 14.4 0.4 1 23 515 538 515 538 0.93
15 18 0.99 1.6e+02 4.6 1.8 1 23 544 568 544 568 0.90
16 18 1.5 2.5e+02 4.0 1.2 2 23 565 587 564 587 0.93
17 18 9.1e-05 0.015 17.3 2.8 1 23 593 616 593 616 0.96
18 18 0.0023 0.38 12.9 5.0 1 23 622 645 622 645 0.97

Sequence Information

Coding Sequence
ATGGATACTATAAACTCGAATAGTGATTGGTCATTATGTAGTTTTCAGATCAAGGAAGAACCTTTGGACATTGAACATGAATCTGaggagTTGATTAATTCAGCGGATAATGTCAAAGCGGAGTTGATTAATTCAGCAGATAATGTCAAGGTGGAGTTGATTAATCCAGCGGATAATGTCAAGGTGGAGTTGATTAATCCAGCGGATAATGTCAAGGTGGAGTTGGAAGAAGAGGAAAGGGTCAAAAcaaagGTGCCAATTGATCCTTTAGCCAATGTTCAAGTGCATTATACAGAAGAGGCATCCTCCAGTGAACCGAGCAGTAGCAGAAAAAGACCAGCTCTGTCATCTTCAGgtcAGGCTAATATTCAAGTGACCAAGCCAAGCAAACTCAACAAGGAATTAAGGCCTTTTCAGTGCACCCTCTGTGAATACAAAGCAAAAATTAAGGctcatttaaaaattcatattgatGGTGTGCATAATGAAATAAGGGCGTTTCAGTGCACACACTGCGAATACAAAGCAAAAATTAAGGCTCatctaaaaattcatattgatGGTGTGCATAAGGAAATAAGGGCGTTTCAGTGCACCCACTGTGAATACAAAGCAAAAACACAGAGTCATGTTAAAAGACATATTGACtctcataagaaaataaaggtgTTTCAGTTTCAGTGCACCCACTGtgaatacaaaacaaattttaagcctcatctaaaaattcatattgatGCTCATAAGGAAATAAGGGCGTTTCAGTGCACCCACTGTGAATATAAAGCAAAAAGAAAGGGTCATCTAAAAATCCATATTAAGTCTGTACATGAAGAAATAAGGGTGTTTCAGTGCACCCATTGTGTTTTCAAAGCAAAAATAAAGGGTCATCTAAAAACCCATATTGATACTGTACATAAGGAAATAAGGGCGTTTCAGTGCACACATTGTGAATACAAAGCAACAACAAATTCTCTtctgaaaaaacatattaatactgTACATAAtgaaataagggcatttcagtgcacCCAATGTGAATACAAAGCAAAAGTAAAGGGTCATCTAAAAACCCATATTGATACTGTACACAAGGAAATAAGGGCGTTCCAGTGCCCCAACTGTGAATACAAAGCGACATCACAGGGTAATCTAAAGATGCATATTAATAATGTACATAATAATGTAAGGGCGTTTCAGTGCACCCACTGTGAATacaaagcaaaaacaaataCTTGCCTGAAAAAACATATTGATACTGTACATAAGGAAATAAGGGCGTTTCAGTGCACCCAATGTGAATACAAAGCAAAAGTAAAGGGTCATCTAAAAACCCATATTGATACTGTACACAAGGAAATAAGGGCGTTTCAGTGCGCTGACTGTGAATACAAAGCAAAAGTAAAGAGTCATCTAAAAATCCATATTGATACTGTACATAAGGAGATAAGGGCGTTTCAGTGCCCCGACTGTGAATACAAAGCAAAAGTAAAGAGTCATCTAAAAACCCATATTGATTCTGTACATAAGGAGATAAGGGCGTTTCAGTGCCCCGACTGTGAATACAAAGCAAAAGTAAAGGCTCATCTAAAAACCCACATTGATGCTATACATAAGGGAATAAGGGCGTTTCAGTGCGCCCACTGTGAATACAAAGCAAAAATAATGCCTGCTTTAAAAAGACATATTGATactTGCACCCACTGTGAatataaagcaaaaataatgcCGTCTTTAAAAAGACATTTTGATACTGTACATTATGATATTAGGGCGTTTCAGTGCACCTATTGTGATTTCAAAGCAAAAACAAAGGGTCATCTTAAAAGACATATTGATTCTGTACATATGGATATAAGGGCATTTCAATGCACCCACTGTGAATACAGAGCAAAAACAAATACTTGTttgaaaaaacatattaatgttgtacataaaaaataa
Protein Sequence
MDTINSNSDWSLCSFQIKEEPLDIEHESEELINSADNVKAELINSADNVKVELINPADNVKVELINPADNVKVELEEEERVKTKVPIDPLANVQVHYTEEASSSEPSSSRKRPALSSSGQANIQVTKPSKLNKELRPFQCTLCEYKAKIKAHLKIHIDGVHNEIRAFQCTHCEYKAKIKAHLKIHIDGVHKEIRAFQCTHCEYKAKTQSHVKRHIDSHKKIKVFQFQCTHCEYKTNFKPHLKIHIDAHKEIRAFQCTHCEYKAKRKGHLKIHIKSVHEEIRVFQCTHCVFKAKIKGHLKTHIDTVHKEIRAFQCTHCEYKATTNSLLKKHINTVHNEIRAFQCTQCEYKAKVKGHLKTHIDTVHKEIRAFQCPNCEYKATSQGNLKMHINNVHNNVRAFQCTHCEYKAKTNTCLKKHIDTVHKEIRAFQCTQCEYKAKVKGHLKTHIDTVHKEIRAFQCADCEYKAKVKSHLKIHIDTVHKEIRAFQCPDCEYKAKVKSHLKTHIDSVHKEIRAFQCPDCEYKAKVKAHLKTHIDAIHKGIRAFQCAHCEYKAKIMPALKRHIDTCTHCEYKAKIMPSLKRHFDTVHYDIRAFQCTYCDFKAKTKGHLKRHIDSVHMDIRAFQCTHCEYRAKTNTCLKKHINVVHKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-