Glac049010.1
Basic Information
- Insect
- Gerris lacustris
- Gene Symbol
- -
- Assembly
- GCA_951217055.1
- Location
- OX578285.1:34269047-34301905[-]
Transcription Factor Domain
- TF Family
- CTF_NFI
- Domain
- CTF/NFI and MH1 domain
- PFAM
- PF00859
- TF Group
- Unclassified Structure
- Description
- Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [2, 1, 5] (also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication [6]. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) [4]. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans [5]. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 1.7e-07 0.0096 17.4 5.3 2 126 30 181 29 185 0.59 2 3 6.6e-12 3.8e-07 31.9 10.3 176 267 183 274 160 290 0.72 3 3 1 5.7e+04 -5.6 4.4 238 238 347 347 278 410 0.58
Sequence Information
- Coding Sequence
- ATGGCTTCTGGAAAAGGAACAAGAAAGGGATTTGTTTGTGGTGACGAGGGCTATTCCCACAATCCATACAATGGAGTAGTTTGCAATGACACCATCCTAGCCACTGGCGTATTCTCTTCCAAGGAACTATGGAGGTTATCTAAAGCTTCGATTGTACATAATCCAAATGGGATGCAACCACCCATCAACGTTATTAAAATAGAGAACCAGGGATACTACTGTAGCAGCTACACTCCCCCTGCTCAGGACCATTCATCTATGCTTACTCCAGGAGCATACAgtcCTCTCTCACTCCCGAGGAGTACTCAAAGTCCTGGAGAACCTAGGATTAAGAAACTAAGAAGGTTAAGCTCCACAGAAGATGAAATGGAATTAGGTAGGGACAAATCAGCAGGAGAAGTACCTTACTATGGACAAAGTCCTGCATCCCTCTCCAGCCAGACAAGTTGGCATTCTGACGTTGAGCATGGTATGCAAACACAACATGGTGCTGTAGCTTCCTTAGCCAGTTCAAGTTATTATCAGCAACAGAATGATCAGAATAGCCCTGCTAAATACCCAGAAAATGGTCATGACACATTATCAGACTTTGTTACGTTTGTTTGCCAAGAAGCTGAAAATACTCAGCCTAATCAGgccGGACCTTCTAGAAGCCCGAATAAATTGGCGCAATACTACCCTAATTCTATGCTTCCTCCCCCACCACCTCCACCAATGGCTAGGCCAGTAGCTATTATCCGGTCAACTGGTGAACTAACTAGTGGCAATAATCATTGTGGCAGTGCGAGTTCTCCGCCTGCATCTATCACACCTCCTGGCCAGTCAGGTGGAGATTCATCCCCTGTTAGATCTCCTTCAAGTCAAGATCAACCACCACATCCCCGTCCTTTAGCATCTAGTCCATTTTCAGTATCTGCAGCTGCTGTGCCCAGAGATTACCCTGTTCCATTTACTCATATTCATACACAACCAGCTCAGttaTTTAGTTACCCGAGTTTGAGTCCTGTTAGTGGAATGTCAGGAGTTATCAGTCCTACTAATCTTTCACTGTTTTCAACATCTATCCCAGTAGGCTCACCTAGAAATAGTTCACGTACTACGTTACCAAGGTGGACACCTCCTGGCCCTCCACCCCCTCCACCACCGGGGCCAGGGCCACCATTCATTACCTTAGAAGAAGACTATATGATGACTCCCCTTATCACATCTAATTCCAACGAGACAACAGCTCTTATGGATGACGatcgaTATTTCAACTCAGTTGTTCAAAGTGGTGAAGCAATGGATTCAGGGATGGAGCCAAGTTCTAACAATTCTACTGGTTCTCATACTCCGCCTAAACCATCTTCACCCAAGACATCTTAA
- Protein Sequence
- MASGKGTRKGFVCGDEGYSHNPYNGVVCNDTILATGVFSSKELWRLSKASIVHNPNGMQPPINVIKIENQGYYCSSYTPPAQDHSSMLTPGAYSPLSLPRSTQSPGEPRIKKLRRLSSTEDEMELGRDKSAGEVPYYGQSPASLSSQTSWHSDVEHGMQTQHGAVASLASSSYYQQQNDQNSPAKYPENGHDTLSDFVTFVCQEAENTQPNQAGPSRSPNKLAQYYPNSMLPPPPPPPMARPVAIIRSTGELTSGNNHCGSASSPPASITPPGQSGGDSSPVRSPSSQDQPPHPRPLASSPFSVSAAAVPRDYPVPFTHIHTQPAQLFSYPSLSPVSGMSGVISPTNLSLFSTSIPVGSPRNSSRTTLPRWTPPGPPPPPPPGPGPPFITLEEDYMMTPLITSNSNETTALMDDDRYFNSVVQSGEAMDSGMEPSSNNSTGSHTPPKPSSPKTS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01009523;
- 90% Identity
- iTF_01009523;
- 80% Identity
- -