Basic Information

Gene Symbol
GIS1
Assembly
GCA_947859175.1
Location
OX401867.1:405479-408344[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 5.8e-05 0.0034 18.0 0.3 2 21 171 190 171 191 0.95
2 16 0.00025 0.014 16.0 0.2 5 23 203 222 201 222 0.96
3 16 1.4 83 4.2 0.8 1 23 229 251 229 251 0.91
4 16 5.4e-06 0.00031 21.2 1.1 1 23 257 279 257 279 0.97
5 16 0.00051 0.029 15.0 0.7 1 19 283 301 283 302 0.96
6 16 0.0048 0.28 11.9 0.5 1 23 417 439 417 439 0.97
7 16 0.00019 0.011 16.4 0.8 1 23 445 468 445 468 0.92
8 16 7.1e-05 0.0041 17.7 1.4 3 23 476 496 475 496 0.98
9 16 4.9e-08 2.9e-06 27.6 1.2 1 23 502 524 502 524 0.99
10 16 0.0017 0.1 13.3 0.0 1 23 530 552 530 552 0.97
11 16 2 1.1e+02 3.7 0.1 6 20 562 576 559 579 0.94
12 16 2e-05 0.0012 19.4 0.0 1 23 632 655 632 655 0.96
13 16 0.00028 0.016 15.8 1.3 1 23 661 683 661 683 0.92
14 16 0.0074 0.43 11.4 0.1 3 23 692 712 691 712 0.98
15 16 0.018 1 10.1 0.0 6 23 721 738 720 738 0.97
16 16 0.0011 0.064 13.9 0.5 6 23 748 765 747 765 0.99

Sequence Information

Coding Sequence
ATGGAGCTCGTCTGTCACAAATGTGAAATGAAGATCACCAGTGACATGTTCTACCAGCATTTGAGTTGTAAGCATGGCAGTGTCAGGGACAAACATGATGTACAATCATTTGTGAGAGATCACGTGACATTTGAAGAGGCCCTCGATTTAGATTTCGATGAAGATTGTACTACGCATAAGTCATCTTCTGAAGCATCGGTAGCGATCCAGCGCTTAGACAGGCAACCTTGGAGCACCACATTTACCGGCAGCTCGCGGCTCTTGCACCACCTATCTAAACATGAGGCGACTCTCGACAGTGTTCCGTGTTGTGGCCCGTCAACGAACCAAACCGAACTTATAAAATGCATGGGAAAAGAACACCCGCCTGAGCCCTTACAACGCAAGAGTAGCGACCGCGTCGCAGCAGGCGATGCCTCGCCGAGCGCGCACATCGCCCATTGCCAAGCGACATCCGGTGAGAGTTTATCTCAAGTGAAATATGAAACCAACCAGAAACGCATCCCAGCCGTCTGCCCGGACTGTAATCGCACATATTCCAACAAGTACGCCATGCTCAAACACATGAAAAATTTCTGTGGTGAAACTAGAGAAAAGTTCGACTGCGACTGCGGGAAGAGCTACACCTCGCGCGGGAACATGGTGGCGCACATACGAAAAGTACATCTCGGCCTGCCGTCGCGGTACGTGTGCAAGCAGTGCGGAGCGATCTACCTGTCTCGCACCACCCGCGACGTGCACCGACGCAAGCACTCGGGCGTGCGGCCCTTCTCGTGTCCGTCCTGTCCGCGGTCCTTCTACACCAAGGTCAGCCTGAAGCGGCACCAGCAGGCGCACGCAACTCGGCACGAATGCGAGCTCTGCGGGGAGGGCTTCAGAAGGAGGGCGCATCTGAAGCTTCACAACCCCTATGAAGACGAACCACTGTTGCCCAGGTTCGTCGCGTCGGAGGACTCGCCGGATCGCGACTCGGACGATTCGAAGACGCCGCTCGCCGAAGTCGCGCCCTCCGAGCCACTGGTCGCCCTGCGGCGTGCGCTCCGCGACCTGCGCGACCACTACTCCGAGCGACACGCGCGCCGCGCGTCCTGCAGCTCCGGCGCCGAGGAGGACCCGTCGCCGGAGAACGGAGATGACCCGGACCGGTTCGACGACCTCACGCGACGGAATATGCGTCGCGATCGGTTCGACGAGGCGACGCGGCGCGCGCTCGACGCCGCCCGAGTGCGGGTCGAGGGCGGCACGCGCTACGCGTGCGGCCAGTGCGGCCGTCGCCTTGCGTCCGCGCACGCCTTCGTGCACCACGCGCGCATCCACTCGGGGGAGCGCCCGCACGTGTGCCACCTCTGCGGGAAGCGGTTCCGGGCGCCGCAGGGGCTCGCACGTCACCTTGCCGAGACGCACGAGCGCCGCCGCCGCCGCGCCTGCCGCCTCTGTCGGCGCACCTTCGCCAACGAGCAGAACCTGCGCCAGCACCTGCGCACGCACACCGGCGAGCGGCCCTTCCAGTGCCCCGAGTGCGGGAAGCGGTTCGCGCAGAGCGGCTCGCTGCACGCGCACCGCCGCACGCACGAGCCGCGCCGCGCCTTCACCTGCCCCGCCTGCGGCGCCGCCTTCCGCCTGCGCGCCGCCCTCGCGCGCCACGCGCTGCGCCACGCCGGCGCGCGCCCGCACCGTTGCCCCTGCGGCCGCGCCTTCGCCGCGCGCCACGAGCTGGCGGCGCACCTGCCGCTGCACGGCGACGCCACCCCGCATGCCTGCGCGCTCTCTCACGCGCGACTCGTTTCCAGGGGCGACGGCGACGTAGTCTGCGCGCCGTGCGCCGCCGGCGCCGAGCCCGCGCCCACCGCCGACGCGGCTGCGGCCGCCCCCCTTCCGCCGCGCGGGAAGCGATTCGAGTGCGGCTCGTGCGGGCGCGCCTTCTCGGACGCGGCGAACCTCGGCCGTCACCGGCGCGAGGTGCACGAGGGGCGTCGCGCGCACGCGTGCGCCTCGTGCCCGCGCACGTTCTCCCGCTCGGAGCACTTGCGCGCGCACGCGGCGCAGCACGCGGGCGAGTCGCCGGCGCTGCTGTGCGAGCGGTGCGGCGCGGCGAGCGCGTCGGCGGCGGCGCTGCGCTCGCACCGGCGCACGCACTCGGCGCCGCGGCACGCGTGCGCGTGTGGCGCGCGGTTCCGGCGTCGCGCAGAGCTGCGCGCGCACGCGTCGGTACACGGCGCTGCGCGGCCGCACGAGTGCGCTTGCGGGCGCTCGTTCCGGCTGCGCGCGCAGCTGAACATGCACATGAAGCGGCACGAGGCGGCCGCCGCACGCGCCGATCGGCTCGAGGAGCCATCGCTGCTAGACCGACTCGCGCAGGGCTCCGCTCCGACGCTGAACTTCGTGGATCTGATGGACTCGTCCGACTCGGAGTCGGAGCACGAGGCGCGGACGGCCCGGGAGACGGAGCCGGCGCCGGCGCCAGCGCACGACCCCTCCTTGGAGATCCTCCTGTTGGGCTCGTGGGCCCGGTAG
Protein Sequence
MELVCHKCEMKITSDMFYQHLSCKHGSVRDKHDVQSFVRDHVTFEEALDLDFDEDCTTHKSSSEASVAIQRLDRQPWSTTFTGSSRLLHHLSKHEATLDSVPCCGPSTNQTELIKCMGKEHPPEPLQRKSSDRVAAGDASPSAHIAHCQATSGESLSQVKYETNQKRIPAVCPDCNRTYSNKYAMLKHMKNFCGETREKFDCDCGKSYTSRGNMVAHIRKVHLGLPSRYVCKQCGAIYLSRTTRDVHRRKHSGVRPFSCPSCPRSFYTKVSLKRHQQAHATRHECELCGEGFRRRAHLKLHNPYEDEPLLPRFVASEDSPDRDSDDSKTPLAEVAPSEPLVALRRALRDLRDHYSERHARRASCSSGAEEDPSPENGDDPDRFDDLTRRNMRRDRFDEATRRALDAARVRVEGGTRYACGQCGRRLASAHAFVHHARIHSGERPHVCHLCGKRFRAPQGLARHLAETHERRRRRACRLCRRTFANEQNLRQHLRTHTGERPFQCPECGKRFAQSGSLHAHRRTHEPRRAFTCPACGAAFRLRAALARHALRHAGARPHRCPCGRAFAARHELAAHLPLHGDATPHACALSHARLVSRGDGDVVCAPCAAGAEPAPTADAAAAAPLPPRGKRFECGSCGRAFSDAANLGRHRREVHEGRRAHACASCPRTFSRSEHLRAHAAQHAGESPALLCERCGAASASAAALRSHRRTHSAPRHACACGARFRRRAELRAHASVHGAARPHECACGRSFRLRAQLNMHMKRHEAAAARADRLEEPSLLDRLAQGSAPTLNFVDLMDSSDSESEHEARTARETEPAPAPAHDPSLEILLLGSWAR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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