Basic Information

Gene Symbol
-
Assembly
GCA_035047105.1
Location
JAWWMK010003389.1:1-4037[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 1.1e-05 0.0017 19.8 0.4 1 20 52 71 52 73 0.96
2 12 0.0015 0.24 13.1 3.6 3 23 83 104 81 104 0.96
3 12 0.0014 0.23 13.1 0.9 1 23 117 140 117 140 0.96
4 12 0.00049 0.08 14.6 4.2 1 21 149 169 149 170 0.95
5 12 0.0065 1 11.1 6.0 1 23 178 201 178 201 0.96
6 12 3.8 6.1e+02 2.4 0.2 13 23 211 222 210 222 0.89
7 12 0.0002 0.032 15.8 0.8 1 21 231 251 231 252 0.96
8 12 0.0004 0.064 14.9 3.4 1 23 260 283 260 283 0.97
9 12 0.00036 0.059 15.0 0.8 1 21 292 312 292 313 0.95
10 12 2.2e-05 0.0035 18.9 9.0 1 23 321 344 321 345 0.96
11 12 0.00062 0.1 14.3 0.9 1 21 379 399 379 400 0.95
12 12 0.00015 0.025 16.2 1.3 3 23 410 431 408 431 0.94

Sequence Information

Coding Sequence
ATGCTGTGCATCGTTACCAACAATGTTGTAAaaattgaaattaaagaagaaTTCAAGTACGTGCCACCTGATTTACCTGATCTACCCCAGCTTTGCGTACGAGTAACACGGCTTTCGCAGTCAATcgatgttgaaaaaaatggcacGACTCAATATAGCTGCCCGAAATGCAAGCAAATATTCAAGCGGTCATGGACTTTGCAACGCCATATTGTTTACAACTGCGGCAAGTCGCAAAGCATTTTTTGTGAACACTGTAATTATTCTTGCAAGCTCAAAAGCTCTCTTGCCCAGCATATTTTCACGGTGCATAAAAAGATGTATGATTCTAAAAAACCTTCTCTACTGTATCAGTGTACTAATTGTAACTATTCTTCCAAATCCAAACGTAATGTCGACCTTCATATCAAGGAAGCACACAATGTCAATGAGCATTCTGAATGGTACAAGTGCACGACCTGCGAAAAGAAGTATAAGCATGAACAAAGCTTGAAAAGACATAAAAAATTGGAGTGCGGAAAAAAGGCTGGTTTCTTCTGCGTTCACTGCAAATATGCTTGCAAGCGTAAAAATAGTCTTACCCTGCATCTCCAAAGAATACATGATTTTCTATGGGACCCGCAAATGCTAAAAGCTAATCTCGCTCGTCACATCAAGTATGTGCACGATTTCAACGAGTATTCCGATTATCATCAGTGCCCTTCATGCGATAGAAAGTACAAGACCAAACAGGCAATGACGGCACATTTGAGATTGGAATGTAGCAAAGATCCCACTTATTTCTGCAATCACTGTAATTACGCTTCCAAGCAGAAATACTCTCTTGCTCTGCACATCAACAAAAGGCatgattcgaaaaaaatacctaaGTCGTACAAGTGCTCGACCTGCGGAAAAATCTACAAGCTGAGAAAGTCTTTAGCaacgcataaaaaaatagaatgtgGAAAAGGGCTCAGATTCAGCTGTGACCACTGTAACTATGCTTTCACGCAAAAACATAATCTCTCTCGTCATATCAGGCACATACATCATTTCAACTGTGACGATGTTTCCAAGCATGAAGATAGTCCTGTTCATATCAAGATCAGACATGACGAAGATGTAGacaattctaaaaaatgttCTCGACCTTACGAATGTACCGCGTGCGGAAAACAATACAAGTACTACAGCGGTTTGAAAAACCATACAAAGCAGGCATGCAACGCGGAAATTCGTTTATTCTGCGATCACTGCAACTATTCTACAATTTTCAAAGGCAATCTTACTCGTCACATCAATGAAGTGCACGAATTTTCTTCCAAATACGCTCCATGCGATGAGAAATACAAAGCTGCACAGCTTtca
Protein Sequence
MLCIVTNNVVKIEIKEEFKYVPPDLPDLPQLCVRVTRLSQSIDVEKNGTTQYSCPKCKQIFKRSWTLQRHIVYNCGKSQSIFCEHCNYSCKLKSSLAQHIFTVHKKMYDSKKPSLLYQCTNCNYSSKSKRNVDLHIKEAHNVNEHSEWYKCTTCEKKYKHEQSLKRHKKLECGKKAGFFCVHCKYACKRKNSLTLHLQRIHDFLWDPQMLKANLARHIKYVHDFNEYSDYHQCPSCDRKYKTKQAMTAHLRLECSKDPTYFCNHCNYASKQKYSLALHINKRHDSKKIPKSYKCSTCGKIYKLRKSLATHKKIECGKGLRFSCDHCNYAFTQKHNLSRHIRHIHHFNCDDVSKHEDSPVHIKIRHDEDVDNSKKCSRPYECTACGKQYKYYSGLKNHTKQACNAEIRLFCDHCNYSTIFKGNLTRHINEVHEFSSKYAPCDEKYKAAQLS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-