Basic Information

Gene Symbol
-
Assembly
None
Location
ML763703.1:1578-14952[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.12 6.7 7.3 7.9 1 23 14 36 14 37 0.94
2 20 0.00015 0.0081 16.5 4.7 1 23 43 65 43 65 0.97
3 20 5.9 3.2e+02 2.0 1.9 3 23 73 93 71 93 0.94
4 20 0.0058 0.31 11.5 0.5 1 20 112 131 112 134 0.89
5 20 3.1 1.7e+02 2.9 0.1 8 23 144 159 143 159 0.82
6 20 0.034 1.9 9.0 8.1 1 23 165 187 165 188 0.93
7 20 0.00012 0.0064 16.8 0.8 1 23 194 216 194 216 0.98
8 20 3.6 2e+02 2.7 0.5 1 8 221 228 221 229 0.91
9 20 0.0022 0.12 12.8 0.1 1 20 267 286 267 289 0.89
10 20 9 4.9e+02 1.4 1.8 3 23 308 328 306 328 0.92
11 20 1.4 74 4.0 0.4 1 21 350 368 350 370 0.70
12 20 0.35 19 5.9 1.1 1 23 376 398 376 398 0.96
13 20 0.16 8.9 6.9 0.3 1 12 420 431 420 433 0.88
14 20 1.7 92 3.7 5.3 2 23 435 456 435 456 0.95
15 20 0.71 39 4.9 2.6 1 23 462 484 462 484 0.94
16 20 0.00027 0.015 15.6 0.3 2 23 525 546 524 546 0.97
17 20 3.6e-05 0.0019 18.4 1.7 1 23 552 575 552 575 0.95
18 20 0.0071 0.38 11.2 1.8 1 23 581 603 581 603 0.97
19 20 0.98 53 4.4 1.9 1 23 609 631 609 631 0.90
20 20 0.016 0.85 10.1 2.8 1 20 653 672 653 675 0.88

Sequence Information

Coding Sequence
ATGAACAAGCACCTCAAGAACCACACTGGCGAGAAGCCGCACCAGTGCACGGTCTGCAGGAAGCGGTTCAAGAGCGGGTGTGCCCTCAAAGAGCACCTGTTCTACCACCACGCCGACAGTGGTCCCTACGAGTGCAGCCGCTGTCATAAGTTCTTTCGGTTCCCGAGCCACCTCATCAGCCACCTCGCCCAACACGTTTGCACTCCGCCCTTCGGGTGCCCGCTGTGCCACAAACCCCAGGGCGACAAGCGCGTCCTGTACCACCACCTCAAGGAGCACGTCCCCCTCAAGGCCGAGCAGCCGCCGTACCAAACACAGCCACCTCCGACCCCTTTCCTCTGCACCGAGTGCGGCGGGACGTTCCGGAGGCGCGAGCGGCTCCTGCAGCACCTGTGGACTCacatccgggcggggcggggccgcggcgggcaGGAATTCAGGCTGGTCGCCAAGTTGAACAACCACCTCAAgacccacactggcgagaaacccCACCAGTGCACGGTCTGCAAGAAGCGGTTCAAGAGCGGCTGTGAGCTCAAAGCTCACCTGTTCTTCCACCACGCCGACAGTGGCCCCTACGAGTGCAGCCTCTGCAACAAGTTCTTGCGGTTCCCGAGCTACCTCATCAACCACCTCCGCGACCACGCGGGTCCGTCTTTTCGGTGCCCGCTGTGCCACAAACCCCAAGGCGACAGCAGGCGGGCCATGTACCGCCACCTCAAGGAGGAGCACGTCCCCCTCAAGGCTGTGGCGCCGCCTTACCGAACACCACGCGagacctccccgccggccgcgttCCTCTGCACCGAGTGCGGCGGGACGTTTCGGCAGCGCGCGTGGCTCCTGCAGCACCTGTGGACCCACatccgTTACCTCATCATTCACATCACCCGCCACGTGAACACGCCGCCCTTCGGGTGCCCGCTGTGCCACAAACCCCAGGGCGACAGGCGCGTCCTGTACCACCACCTCAAGGAGCACGTCCCCGTCAAGGTCGTGCGGCTGCCGTACCAAACGACCCGCGGGCCGACACCTCCAGCCCCGTTCCTCTGCACCGAGTGCGGCGGGAGGTTCCGGAACTACCTCATCAGCCACCTCGCCCAACACGGGAACACTCCGCCCTTCCGGTGCCCGCTGTGCCACAACCCCCAGGGCGACAAGCGTGCCCTGTACCGCCACCTCAAGGAGCACGTCTCCCTCAAGGCCGTGCAGCCGCCGTACCAAACACCCCGCGGACCGCCACCTCCAGCCCCGTTCCTCTGCACCGAGTGCGGCAGGAGGTTCCGGAATGGCCCCAACGAATGCAGCCTCTGCCATAAGTTCTTCCTGTTCCCGTGCCACCTCATCAGCCACCTCGCCCAACACGGGAGCACTCCGCCCTTCCGGTGCCCGCTGTGCCACAAACCCCAGGGCGAAAGGCGTGCCCTGTACCACCACCTCAAGGAGCACGTCCCCGTcaaggccgagcagcagccgcaccaggTCACCGCAGGGacgtcctcgccggccgcgtgcCACAAACCCCAGGGCGATAGCCGGGCCCTGTACCACCACCTCAAGGAGCACGTCCCCtgcaccgtgtgccaaaAGGAATTCAGGTCGGGCGCCGACATGAGCAGACACCTCAAgacccacactggcgagaagTCCCACCAGTGCACGGTCTGCAAGAAGCGGTTCAGGAACGGTAGTGCTCTCAAAGCGCACCTGATCAACCAGCATACCGACAGTGGCCCCTACGAGTGCAGCCTCTGCCATAAGTTCTTCCTGTTCCCGAGCTACCTCATCAGCCACCTCGCCCAACACGGGAACACTCCGCCCTTCCGGTGCCCGCTGTGCCACAAACCCCagggcgccagccgggccctGTACCACCACCTCAAGGAGCACGTCCCCGTCAAGGCCGAGCAGCTGCCGTACCAAACACCCCGCGgaccgccgcctccggccccgtTCCTCTGCACCGAGTGCGGCAGGAGGTTCCGGAAGTGCGAGCGGCTCCTGCAGCACCTGTGGACCCACATCCGGGCCGATACCACCGCTGCTGTGTGA
Protein Sequence
MNKHLKNHTGEKPHQCTVCRKRFKSGCALKEHLFYHHADSGPYECSRCHKFFRFPSHLISHLAQHVCTPPFGCPLCHKPQGDKRVLYHHLKEHVPLKAEQPPYQTQPPPTPFLCTECGGTFRRRERLLQHLWTHIRAGRGRGGQEFRLVAKLNNHLKTHTGEKPHQCTVCKKRFKSGCELKAHLFFHHADSGPYECSLCNKFLRFPSYLINHLRDHAGPSFRCPLCHKPQGDSRRAMYRHLKEEHVPLKAVAPPYRTPRETSPPAAFLCTECGGTFRQRAWLLQHLWTHIRYLIIHITRHVNTPPFGCPLCHKPQGDRRVLYHHLKEHVPVKVVRLPYQTTRGPTPPAPFLCTECGGRFRNYLISHLAQHGNTPPFRCPLCHNPQGDKRALYRHLKEHVSLKAVQPPYQTPRGPPPPAPFLCTECGRRFRNGPNECSLCHKFFLFPCHLISHLAQHGSTPPFRCPLCHKPQGERRALYHHLKEHVPVKAEQQPHQVTAGTSSPAACHKPQGDSRALYHHLKEHVPCTVCQKEFRSGADMSRHLKTHTGEKSHQCTVCKKRFRNGSALKAHLINQHTDSGPYECSLCHKFFLFPSYLISHLAQHGNTPPFRCPLCHKPQGASRALYHHLKEHVPVKAEQLPYQTPRGPPPPAPFLCTECGRRFRKCERLLQHLWTHIRADTTAAV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-