Basic Information

Gene Symbol
-
Assembly
None
Location
ML763076.1:613249-623380[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.00012 0.0064 16.8 0.7 1 23 703 726 703 726 0.97
2 17 0.099 5.4 7.6 0.1 2 23 733 754 732 754 0.94
3 17 0.0052 0.28 11.6 2.9 1 23 761 784 761 784 0.93
4 17 0.0047 0.25 11.7 0.0 2 23 790 811 789 811 0.96
5 17 0.0015 0.082 13.3 0.1 2 23 816 838 815 838 0.90
6 17 0.00013 0.0072 16.6 5.1 1 23 1428 1451 1428 1451 0.98
7 17 1.7e-05 0.00093 19.4 0.9 1 23 1457 1479 1457 1479 0.97
8 17 1.2e-05 0.00065 19.9 0.9 2 23 1485 1506 1484 1506 0.97
9 17 0.0093 0.51 10.8 1.0 2 20 1513 1531 1512 1533 0.92
10 17 0.00029 0.016 15.5 0.3 1 23 1541 1563 1541 1563 0.97
11 17 0.0043 0.24 11.8 4.4 1 23 1569 1591 1569 1591 0.99
12 17 1.9e-06 0.00011 22.4 1.7 1 23 1888 1910 1888 1910 0.98
13 17 5.9e-05 0.0032 17.7 0.8 1 23 1917 1939 1917 1939 0.96
14 17 0.054 2.9 8.4 4.3 1 23 1944 1966 1944 1967 0.89
15 17 0.31 17 6.0 1.8 3 23 1974 1993 1967 1993 0.91
16 17 0.59 32 5.1 0.1 3 20 2019 2036 2017 2039 0.79
17 17 0.012 0.67 10.4 3.1 1 23 2046 2069 2046 2069 0.96

Sequence Information

Coding Sequence
ATGGAAGATCTCGAAGCTGGTTTGTCAAACCTTTGCCGCTTGTGTGGTGAAGTTGATGTTGAATGTTCCAATTTGTTCGATGAGacagaacaagaagaaaactTACTCTCTAAAATCCAACTTTCAATAAGAATAGCGATTTCGCAAGATGATGGTCTTCCATCAGGGATTTGCAATGCATGCCGTGATAAGCTGGTTGACTACACCTCATTTTATCAACAATGTCATGATACTCAAGAAAGACTGCAGGAGTTCCTATGTATTGAGTCTGCTATGCAGAAAACAATTCACGCCGATCCACCCGAGATAAAATTTGAAGCTGTTACTGAACATGAAGATGAAGCTGATGACTTTTACTATGAGGACGCTGAAGGTGGAGCTGATGAGAATGTTGACGATGAGAATGTTGAGTACATGGAAACTGAAGAAAATAATGAGAttccagaagaagaagaatacaTTCTAGCAGATACAGAAAAAGATAGACGTTCATTTGCTGcctctgagagagagaaaacacttCCTGTGAGAAATTCTTCACCTGGGAAGAAAAAGGATGTATTGCAAGTCAATTTGACTAATTCTAACTCTCTacaagagggaaaaagaaaaactattGGTCGTTTGAATAATCAGAAAGAAGATCCCCTAGTATTACCCTTGGCCAAACAGGTTCAAAACTCCAAAATGCATATAACTGCACCTATTAGTAAAATTGTCGATAATTGTTTATCATATAGTAGTGGCTCAAGCTCTTCTTGTACTCAGACCTCTAGAAGTTTGGTGTCCTCATCTGAGCCACCCCCTCTTGTTCAAATAGTTACAAAAACAGTAGTACCTCTGGAAGTTCCTCCCTTAGTTCCGATTAAGAAACCTCTATCTCAGAAAACATCTACTCAAGCTCCATCTGTTAAAATTTTGGAAGCTAAAACAAACACTTCCTCATCACCCACTGTCAAAGCCGCACCATCAACATCACCACTACTTCTTCCGTTCGTCAAACTGTCAAGATTGCCAGAATCTTCCTTACTCAAACTTGTTAAGGGATATTCTCCAAACCAGGCCAAACCTTCTGAAAAATTATCTACATCAAAGAAGAATGAAAAATCTGCAAATACTCTGAAGCCAACCGGATCGCCTACTGTAGTTCAGAACAAGTTGTCAATGGAACCTCCACCACTTGTTAGGCGTTTGGAAACTAAACAAGGAATTGAATCATTTAATGTTGCGAGGAAAAGGGTGGCTGTGGAACTTCCATCAGTAGCAACTAGTAGTGGTGCAAAAGGACGGGTTTTTATTATGGCAGAAGAAAACACTCCTTTGCTTATTCCAGAAAACGCATTACCTGTAATTAGACCAAAGAAACTTCCTGTTAAAGCCAAATCCccatcaaaaaagaaaaagggtgaTTTGTCTGTCATGGCTAATAATGACCCAACCAAAACCCTAAACCCTtcaagaggagaggggcgggcttTCATTATGACAGGGGATAAAACTGTGGCTGTGGAAGTTGGAGTTGTCCAAAATactaagaaaaaaaagaagagaaaacctCCCTCACTGCCTGCAACTTCTGTTCCCTaccttattttgaaaaatggaGAGCTTGTTAACCTGGACATGGTGGAAAAAATTCCATTAGATCAAATACCGACACCTCCAGTTGTTGTAATGCATGTGTCTAAAAATGTGGCTACCCCTCCAACCATTGGTGTGGAGGGTCATATAAACTTTCCTGATATTTCAAGCTATACAGGTTTTCCTGTAGATCTAGGGTCTGGTCTTCATGTGCGTTCCTACCCTGAGACCACTTTTAAAGAATTTAAAGTATCCTTGCCAGAAACCCAAAATAATAGTGAGGAAAATGATAAACTTTTGGTTGTTCAGAATAGTTGGTTACGACAACATAAGAAGAAAGGAATTTTTGTAAGAAAGCATAAAAGAAGATGTCGTCCATCTTCTTGCCCAGAGGCTACTGTTCAAGTAGAAGACATTCCCACTGATCCACCACAGTTTAGATGCAAAATATGTGATGTCCTTTATGTGGACAAGAAACGTTGTGAATATCATGTAATCAACAAACACATGACTGATAGCTGTGCTTATCAGTGTAAGGAATGTGGTCGAAAATTTGCTACAAATTTCCTTAGAGCAGCCCATATAAGGTTGAGACATGTTCGAGCTCCAGATTTAATTTGTAGTATCTGTGGTGCAAAGTTTAGGTCAATTGAAGTTTTGAAAGGTCATGAATTGCGCCACACTTTAACAGAACCTCCATTTAAATGCAGCACGTGTGGCAAAGGCTTTTACACAAAAGCCAACTGTGTCAAACATCAACTAGATCTGCACTCAGAAAAGAAAGTAGTCTGCGATATATGTGGTGAAGCATTTTCTTCAGGAGGCCGTTTGAATGAACATCGCTTTACTCACTTAGGAGGTATAAAATGTAACGAATGTGGGAAAGTAATAAAATCAAGAAGTAGACTTCGTGCCCATAAAGCAGCTGCTCACTCTAAAGAACAGAACTTTCTGTCTGTCGGATCAAACAGCAATCATACTGAAGAGGAACGAGCACCTGAGACAACTTTACCACCACCTCTTACCCCAATACAGCTGTATGAGCCACTTGACAGTGAGCAGAGTGGGGAAGTGCCTCTTGAAAGCACCTTAGGTCTTTCATTATTTGATGATATTGATAAAAATAGCTCAAGCTTTCGAAAAGAAATGGATGTTCTTTTATGTGGAGAAACAGATAGCCAGCCATCAGTTGCTCATTTGTCATGCTGCTCAGAACCTAGATCTTTAACATCTCCTAGTTTTAGTCTACAAGACTTCTCATTAGACCAAGGGAACCACCTTCCTATTAACGAATTTCCCTTATCTGAGGAACAGTTACCACCTGTTAAAACTGCTTCAGAAAGGGAAGATAATGAGTTAGAATACACAGCTGTTTCCAAACCTGGTGATAACGAACATTGTGCAGAAAATAACCTAATGGCAGAGGTTCCTAAACTATCCTGTGGGTTTGGAGATGAATCAGTAGTAGTTCATAGTGACAAGTCTCTAACTCAACATACATTTGAACATCAATTAGTGGAAAATATTTCAAGTCAGGCTTTTACCTCAGCCAATCATTCAATAATTCAAGACCAGACATTAGGATCATTACCAAGCTTTCAGGGAAATGTGAGCTCTGAGATGGATTCTCTCAGAGTGCAAAATGAGGCAAACACTGTGTTAACAGTTGATGCCAAGGTGGTTGGTGCGTCAGGTGAAATCAAGTTCCAGCGCAACATGGGTGGAGTTAAAATTGTCTTCCCTCCAACAACAGCTGAGAAAGCTATCAAGTTTGATGACCTCATCAGCCTGTTTTCTCTGAATGAAGTTCGTCAAGCATTTTGCGCTGAaagtaaagaagaagaaattatTCAACAACTAGTCCAGCAAGGATTAGGTAGTGAAGGTGTTCCTCAGAGTGGTCGAATGTCCTCTCTATCACAAGCTAGTTCCCTGGATCTTCCAAACAGCCTTTTAAGTCCATTATCATCAGTATGCGATTCATGGAGCTGGGAGATTTCTCAGTTACTAAGTGGAGATGAGAACAGTAATGAAGGAGATAATAGAAGTGAACTAAATACCCCAATTGTGACTCTCCCTCCAAAACAAACTGATTGTACCAATGTAGTAAAGTCCATTCAGACAGCACCTCCCTCTTATGATGTTTCATTAGATGTGCCATCAACATCTGTTCTTGACAACTTTTGCATGCCCTCCAATTTTAAGATTTCAGGTTCCAAACTTTTACCTTCGCCTGACAGTAACACATCACACATCCCTTGTAATCTTAATATTCCTCAGGGTATTTTCACTCCTCTTCAAGTTCAGATACCAGAAGAAAGTGACACTCCCCCCAGAATATCTCGAACATTGAATTCTTCTAACACATACTTTGATGAAATAAGTCTAGGAATATCCCCTGTTATTGATTTAGACCCTAATGTGGCCACAGTACGAATGTCATGCCCCCCGACTGAAAATTCTCAACAGTCATCCTTTAGAAGAGGAATTGAAACACTGTCTCTTCAGGCTCCAAATTCTTCATATATATCAAATGAACTACCGAGTACTGATGCTTGCCCTGCTGTGGTATCCAATGATGATGACTGTGATATAAAAGAAGTAGCTGTAGATATAATAATAGATGATGGGAAGATGAACTGGCTCAAACTCCTTCCTGATCCTACTGATGAGtttgtgaaaaaaatttctcatAAATGTTATAAATGTCATATTTGCTCAAGAAGCTTCAGATTTAAATTTCAGGTACAGAGACATATAAAAATTACTCACTCAACTTCAAAGCCTTTTATATGTGCCATTTGTGGTGCGACTTTTAGTATAAAACATTACTTAACTAGACACATGAAAGTTCATGATGATACTAGACTTCAATGTACATTGTGTGATAAAAAGTTCACTCGTCAGTATCAGTTAGCAGAACATGAGCTAACGCATACAGATCCTTCATCTTTGAAATGTTCCGACTGTGGTAAGCAGTGCAATAGTAAGAATGCTCTCAGTGTTCATAAATCAATTTGCTCTGGAACTTTACAATCTTACATATGTGATATTTGTGGGAAAACTTATCCTGGTTTAACTGCGTTGAATCATCATCGGGCAAGACATGAGCCAGTTAAATTATTTAAATGTACAATGTGTGAATCTTCATTTCACACGCAGTGGCAGCTTGTGAAACACACTAAACGACATGCCACACAGGGTCTAAATGAAGAAGAGAGACTTTTATCGAGTCCTGTTTCTATCATTGTTGAGGACCTGGAAAATGATACTATTACTGACAACTTTGACGAAACAGTGCAAGTGGACCATTCTGAAATTCTGCCTGGAAGTCCAAGAAAAAAGCTTGTATATCTGATTAAAAATGCTGGTAATATGCCAGTCCAAACAGTTCTCTCTGCTGTTTTGGGAAATCAAGAATCAAATTCCTCTAGGGGTAAAAGTTTGCTAGCGCCTCTAAGAAAAACTCCTACAGGAAAGACGCAGAATAGCAAACACCCCCCAGATAATAAATTGAGTCAAAAGGTGGTGATCAAAGGAAGTGATGGTAAGGAGAATATGATTCTTTTGGATGTTCCTGTGCCTCTTAACATGGTTGCTACTGAAATTCAAGAAAACTCTGAAGATGTGGATGATCCTACCTGGGCTCCACCTAGCTCTGAAAATACCTCTAAAAGAAAATCTTCATGGTCTAAGCTGAAAAGAGCGAGGACGGCTGTGAGAAATAGCATGAAAATATTGCGCCTTCCTAAACCCCGAAATAAGAGGGAATCTAGGGCAGAGCGACCATTAAGGACACCTGTTCGGAAGCAAGCACCCATTTCCAAAGATGATCCAAACTATGCCATAATGATGGAGAAATTTGCAAAACCAGTATCTATATCAACCTTAAAACGACATGGACTGTATCAACCAAAACCAAATGGCTATAAAATTAATGCGCCATACAAAAAAGATGTAGCTCCTTACATTGAGAAAGTGTCTGACACTGAATTTAAGTGCAAAATTTGCCTTTCTGCTAAATTTAGATGGAATTATAAGGCTGAAATTCACATTTTAGAACATTTAGATTGGAGACCTTTTGAATGTGATGTTTGTGGAAGGTCATTCACTCAAAACCAGTACTTAACAAAACATAAAAGACTGCATTTTCCTGATGATACCAATTTCATGTGTGAAGTGTGTGGGAAGGGTTTCCAGCGGCGCtattatttgacatatcatATGGATGAACATTTTGACAGAACGTACAGTTGTGAAGATTGTGGTAGAAAATTTACACGACGTCAAAAGCATGATGAGCATGTTAGGTATCACCACAAATGCCACTATTCTATTTGTGACATCTGTGGCCAAACATTGCGGACCACTGCTCTCTCAAGGCACCGGAAACAGCACGGAGAAAAGAGCCagggaaggaaaaagagagagagcgcagccAGCTCTGGAACTTCTCAATCTACTTGGCTCGCTTGTGGTGTATGTGGTCGTGCTTTTCGCTCTCTGCGGGAAAGAGATGACCATGAAGCAGAACATAACAACCCCCTGCTTCCGTTCCAATGTGAACAATGTGTTGTGTATTTTAAGTCAAAACGTACTCTTAACAATCACATTATGCACACCCATAGTCAGATTGGTGAAGAAGAATGTGAGGTTGCTACTCAAGAAGAGGAGTGTGATGATGCCTCTCAAGTGCTTGACGAACTTTCTTCAACCATTGTTGTGAGCATCCCTGGTGAAATTTAG
Protein Sequence
MEDLEAGLSNLCRLCGEVDVECSNLFDETEQEENLLSKIQLSIRIAISQDDGLPSGICNACRDKLVDYTSFYQQCHDTQERLQEFLCIESAMQKTIHADPPEIKFEAVTEHEDEADDFYYEDAEGGADENVDDENVEYMETEENNEIPEEEEYILADTEKDRRSFAASEREKTLPVRNSSPGKKKDVLQVNLTNSNSLQEGKRKTIGRLNNQKEDPLVLPLAKQVQNSKMHITAPISKIVDNCLSYSSGSSSSCTQTSRSLVSSSEPPPLVQIVTKTVVPLEVPPLVPIKKPLSQKTSTQAPSVKILEAKTNTSSSPTVKAAPSTSPLLLPFVKLSRLPESSLLKLVKGYSPNQAKPSEKLSTSKKNEKSANTLKPTGSPTVVQNKLSMEPPPLVRRLETKQGIESFNVARKRVAVELPSVATSSGAKGRVFIMAEENTPLLIPENALPVIRPKKLPVKAKSPSKKKKGDLSVMANNDPTKTLNPSRGEGRAFIMTGDKTVAVEVGVVQNTKKKKKRKPPSLPATSVPYLILKNGELVNLDMVEKIPLDQIPTPPVVVMHVSKNVATPPTIGVEGHINFPDISSYTGFPVDLGSGLHVRSYPETTFKEFKVSLPETQNNSEENDKLLVVQNSWLRQHKKKGIFVRKHKRRCRPSSCPEATVQVEDIPTDPPQFRCKICDVLYVDKKRCEYHVINKHMTDSCAYQCKECGRKFATNFLRAAHIRLRHVRAPDLICSICGAKFRSIEVLKGHELRHTLTEPPFKCSTCGKGFYTKANCVKHQLDLHSEKKVVCDICGEAFSSGGRLNEHRFTHLGGIKCNECGKVIKSRSRLRAHKAAAHSKEQNFLSVGSNSNHTEEERAPETTLPPPLTPIQLYEPLDSEQSGEVPLESTLGLSLFDDIDKNSSSFRKEMDVLLCGETDSQPSVAHLSCCSEPRSLTSPSFSLQDFSLDQGNHLPINEFPLSEEQLPPVKTASEREDNELEYTAVSKPGDNEHCAENNLMAEVPKLSCGFGDESVVVHSDKSLTQHTFEHQLVENISSQAFTSANHSIIQDQTLGSLPSFQGNVSSEMDSLRVQNEANTVLTVDAKVVGASGEIKFQRNMGGVKIVFPPTTAEKAIKFDDLISLFSLNEVRQAFCAESKEEEIIQQLVQQGLGSEGVPQSGRMSSLSQASSLDLPNSLLSPLSSVCDSWSWEISQLLSGDENSNEGDNRSELNTPIVTLPPKQTDCTNVVKSIQTAPPSYDVSLDVPSTSVLDNFCMPSNFKISGSKLLPSPDSNTSHIPCNLNIPQGIFTPLQVQIPEESDTPPRISRTLNSSNTYFDEISLGISPVIDLDPNVATVRMSCPPTENSQQSSFRRGIETLSLQAPNSSYISNELPSTDACPAVVSNDDDCDIKEVAVDIIIDDGKMNWLKLLPDPTDEFVKKISHKCYKCHICSRSFRFKFQVQRHIKITHSTSKPFICAICGATFSIKHYLTRHMKVHDDTRLQCTLCDKKFTRQYQLAEHELTHTDPSSLKCSDCGKQCNSKNALSVHKSICSGTLQSYICDICGKTYPGLTALNHHRARHEPVKLFKCTMCESSFHTQWQLVKHTKRHATQGLNEEERLLSSPVSIIVEDLENDTITDNFDETVQVDHSEILPGSPRKKLVYLIKNAGNMPVQTVLSAVLGNQESNSSRGKSLLAPLRKTPTGKTQNSKHPPDNKLSQKVVIKGSDGKENMILLDVPVPLNMVATEIQENSEDVDDPTWAPPSSENTSKRKSSWSKLKRARTAVRNSMKILRLPKPRNKRESRAERPLRTPVRKQAPISKDDPNYAIMMEKFAKPVSISTLKRHGLYQPKPNGYKINAPYKKDVAPYIEKVSDTEFKCKICLSAKFRWNYKAEIHILEHLDWRPFECDVCGRSFTQNQYLTKHKRLHFPDDTNFMCEVCGKGFQRRYYLTYHMDEHFDRTYSCEDCGRKFTRRQKHDEHVRYHHKCHYSICDICGQTLRTTALSRHRKQHGEKSQGRKKRESAASSGTSQSTWLACGVCGRAFRSLRERDDHEAEHNNPLLPFQCEQCVVYFKSKRTLNNHIMHTHSQIGEEECEVATQEEECDDASQVLDELSSTIVVSIPGEI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-