Basic Information

Gene Symbol
-
Assembly
None
Location
ML763023.1:414481-416538[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 0.09 4.9 7.7 0.0 1 23 15 37 15 37 0.96
2 22 0.00095 0.052 13.9 1.4 1 23 42 64 42 64 0.94
3 22 0.46 25 5.5 4.3 1 23 120 142 120 142 0.95
4 22 6.7e-06 0.00036 20.7 3.0 1 23 145 168 145 168 0.97
5 22 5.1e-05 0.0028 17.9 1.2 1 23 174 196 174 196 0.95
6 22 3.3e-05 0.0018 18.5 3.8 2 21 203 222 203 224 0.95
7 22 8.6e-06 0.00046 20.4 1.0 1 23 230 253 230 253 0.98
8 22 2.9e-05 0.0015 18.7 1.5 1 23 259 281 259 281 0.97
9 22 1.2e-06 6.4e-05 23.1 1.1 1 23 287 309 287 309 0.97
10 22 0.00026 0.014 15.7 0.9 1 23 315 338 315 338 0.97
11 22 2.9e-05 0.0015 18.7 1.5 1 23 344 366 344 366 0.97
12 22 0.0016 0.088 13.2 1.6 1 21 372 392 372 394 0.94
13 22 1.3e-05 0.0007 19.8 0.6 1 23 400 423 400 423 0.98
14 22 1.2e-05 0.00066 19.9 4.3 1 23 429 451 429 451 0.97
15 22 2.1e-05 0.0011 19.1 0.5 1 23 457 479 457 479 0.95
16 22 0.00011 0.0058 16.9 2.8 2 23 486 508 485 508 0.95
17 22 1.5e-05 0.00083 19.6 1.3 1 23 514 536 514 536 0.97
18 22 0.02 1.1 9.7 3.2 1 20 542 561 542 564 0.94
19 22 1.6e-06 8.6e-05 22.7 1.4 1 23 570 593 570 593 0.96
20 22 2e-06 0.00011 22.3 3.4 1 23 599 621 599 621 0.98
21 22 2.2e-05 0.0012 19.1 3.7 1 23 627 649 627 649 0.97
22 22 0.0029 0.16 12.4 7.1 1 23 655 678 655 678 0.94

Sequence Information

Coding Sequence
ATGCGATCTCGACTCAAATCGACGGCGACGCTCTCGTTACCCTTTAGGTGCTCTGTGTGTAGTGATAGCTTTGAGGCAGAGGACGCGTTGAAGGAACACCTGGTCATCCATGTAGACCAGGTGTTTGAATGTGATGTGTGCTACCAGAGGTTCAGTCGTGCAACACTTCTTAAAATACACAAGACATTCCATGAAGAGGAAGTTGCTGGTAGTGATTTGGAAGCTTCTGAACATTCGGAGTTTTCGTTGTCATCGGACTCAGGATCAGATGAGTGCTCGGGAAGTAAGGACACTATCTCAGTGGCAGAGACACGTCGCCAGCGTGCTGTGCCCAGATCGCAGCCCAATGGTTCGCTGTACAGTTGCATAGTATGTCCGAAAACTTTCCATAACAAGACAGATTGCTGGAAACATCGTGCAACGCATACTGCCTTTAATTGTGCAGATTGCAATAGGACGTTTAAGCGCTTAGAACACCTAAAAAATCACCGACTTACGGTCCATTCAACTGCCAGACCTTACTCTTGTCACGAATGCGACAAGTCGTTTAAGCTGGTTCGTGATCTTCAAAAACATGCTGTTATTCATTCGGCCAGGAAACGGCGTAAATGTACTCTGTGTGATAAGGCTTTCCGCACAACAAGTGATCTTACGAACCATATGCGCTGCCACTCCGAAGAGAGGTCGTATAAGTGTACTTTGTGTCCCAAAGCTTACAAACGTGGAGCTCATTTACAGAATCATATTCAATCTGTTCACTGTGATGAACGGAATTTCGACTGTACTCTGTGTCAGAAATCTTTTAAACTTCGCGACTATCTTGTAAGTCACATGCAATCTCACACGGAAGAAAAGCCACATGTGTGTTCTGTATGTAATAAGGCATTTCGCACAGCAGTGTATCTCAAGACTCATATGGCAACCCACTCTGACACGAGGTTGTTTGAATGTACTTTGTGTCCCAACGCTTACAAACGTGGAGAACATTTAAAGAAACACATTCAATCTGTTCACTGTGACGAACGGAGTTTCGACTGTACTCTGTGTCAGAAATCTTTTAAACTTCGCGACTATCTTGTAAGTCACATGCAATCTCACGCGGACGAAAAGCCACATGTGTGTTCTGTGTGTAATATGGCTTTCCGCACAACAGGTGGGCTTGCGAAGCATATGAGCTGCCACTCCGAAGAGAGGTTGTTTGAGTGTAGTTTGTGTCCCAAAGCTTACAAACGTGGAGAACATTTGAAGATTCACATTCAAACCGTTCACTGTGATGAACGGACTTTTGACTGCACATTGTGTCAGAAATCCTTTAAATTGCGCATTCACCTTACTCGCCATATGCAGACTCACACAGATGAAAAGCCACATGTGTGTTCTGTATGTAATAAGGCGTTTCGCACAGCAGGTGACCTTAAGATTCATAGTGTGACACACTCTGACGCGAGGTTGTGTGAGTGTACGTTATGTCCTAAAGCTTACAAACGTGGAGAACATTTAAAGAAACACATTCAATCTGTTCACTGTGACGAACGGAGTTTCGACTGTACTCTCTGTCGGAAATCTTTTAAACTTCGCGACTATCTTGCAATTCACATGCGGTCTCATACAGATGAAAAGCCACATGTATGTTCTATGTGTAACAAGGCTTTCCACACAACAGGTGGGCTTGCGATGCATATGAGCTGCCACTCCGAAGAGAGGTTGTTTGAGTGTACTTTGTGTCCCAAAACTTTCAAACGTGAGGACCATTTAAAGAATCACGTTATCTCAGTTCACTCTAATGTCAAACCGCACAAATGCTCGGTTTGCAAAAAGTCGTTTTCCCTTCCGTCGCTGCTGACCTCTCATATGAAGCGGCATGTGACAGCTCGACCACACAAGTGCAAACTATGCAAGAAACGGTTTAAAACTTCTAGTGATATGCAAGCTCACCGAGCCGTACATTCGGATAAGAAGCCCCATAGTTGCCATCAGTGCGGCATGAAGTTTAGGCGCTTTGCCCACCTCAAAGTGCACTTTTCCCGAATACACTCTGCCGAAATTGAGGCTGCCTGA
Protein Sequence
MRSRLKSTATLSLPFRCSVCSDSFEAEDALKEHLVIHVDQVFECDVCYQRFSRATLLKIHKTFHEEEVAGSDLEASEHSEFSLSSDSGSDECSGSKDTISVAETRRQRAVPRSQPNGSLYSCIVCPKTFHNKTDCWKHRATHTAFNCADCNRTFKRLEHLKNHRLTVHSTARPYSCHECDKSFKLVRDLQKHAVIHSARKRRKCTLCDKAFRTTSDLTNHMRCHSEERSYKCTLCPKAYKRGAHLQNHIQSVHCDERNFDCTLCQKSFKLRDYLVSHMQSHTEEKPHVCSVCNKAFRTAVYLKTHMATHSDTRLFECTLCPNAYKRGEHLKKHIQSVHCDERSFDCTLCQKSFKLRDYLVSHMQSHADEKPHVCSVCNMAFRTTGGLAKHMSCHSEERLFECSLCPKAYKRGEHLKIHIQTVHCDERTFDCTLCQKSFKLRIHLTRHMQTHTDEKPHVCSVCNKAFRTAGDLKIHSVTHSDARLCECTLCPKAYKRGEHLKKHIQSVHCDERSFDCTLCRKSFKLRDYLAIHMRSHTDEKPHVCSMCNKAFHTTGGLAMHMSCHSEERLFECTLCPKTFKREDHLKNHVISVHSNVKPHKCSVCKKSFSLPSLLTSHMKRHVTARPHKCKLCKKRFKTSSDMQAHRAVHSDKKPHSCHQCGMKFRRFAHLKVHFSRIHSAEIEAA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-