Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.0054 0.46 11.8 0.2 1 23 222 244 222 244 0.97

2 4 4e-06 0.00034 21.7 2.4 1 23 252 274 252 274 0.95

3 4 1.4e-06 0.00012 23.1 2.3 1 23 280 302 280 302 0.95

4 4 2.7e-06 0.00023 22.2 4.6 1 23 308 330 308 330 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.0054	0.46	11.8	0.2	1	23	222	244	222	244	0.97
2	4	4e-06	0.00034	21.7	2.4	1	23	252	274	252	274	0.95
3	4	1.4e-06	0.00012	23.1	2.3	1	23	280	302	280	302	0.95
4	4	2.7e-06	0.00023	22.2	4.6	1	23	308	330	308	330	0.97

Coding Sequence: ATGGCAAATTACTCTCCGCAACATCGTAACGAGAGTCCAGGTGGCACAGGTCACTGGCAGCAATCTGTCAACCACCTGCAAACTGCAGAAGGGTCCATTCAATATGCTCGTGGACAGAATGATTCGAGCAACAACACCAACGGGACCTCTAATGGAACTTCTTTTCAACGTCAGGAACAGCCTGGATCTGTTATTACCCGGATGACTCCGTACACTACTCCTTGGAACTATAGTGCTGAGCATATTCGTATCCCAACTGCACCTGttcctggccctggcccagaGCCGATCGGTTACACCAACCAGCAAGCATACCCTTCTGGCCAAGATGGTCAGCGCATTGCTGCACCTGGACGTATTTGGAATGCAGTGAAAGATGAGCCTGAAGATTTGACAGGGCGCCATGCTGGAAACAACAAATCTCATCCAGATGACGCCCAAGCAAACACTAATGACTCGGATAGTGATAATGACAGTGATCTCTGCATTGATGAACAACAACGTGCAGGAACTCTTCCCCGGAAAAGGAAAGGTGGAATATCTGCCTCTGTTATGAATGGTGTAACACCTGCAGAGCTACAAAAAAGACCAGGATTGATACCACTTACATCTAATTTAGCTGGACCTGTGCAAGTTATGACAGCCAAGGATGGTGCCAAATTATACTCATGTCCTGAGTGCAACCTATTTTACGCTGATCATCTTGCCTTTGAAATCCATCTTCAAGCGCATGGTGTCTCTCTTGGAAAACGACATATTTGTAAGGAGTGTGGTACGAGCTTTCGCCGTAGAGAGCATCTTGATGCTCATATGACAGCTCACAGTCAAGATAGACCCTTTTCCTGTGAAACTTGTGGGCGTGCTTTTAAGAGGAATGAACACCTCACAAGACATCGGGTTTTGCATTCAGGGGACAAGCAGCATGTTTGTGCTGATTGTGGTAAGTCTTTCTTCCGCAAAGATCACCTCATGAAGCACTCCCAGACCCACATGTTGAGGAAGATGACATCGGGTGAAGGCTGA
Protein Sequence: MANYSPQHRNESPGGTGHWQQSVNHLQTAEGSIQYARGQNDSSNNTNGTSNGTSFQRQEQPGSVITRMTPYTTPWNYSAEHIRIPTAPVPGPGPEPIGYTNQQAYPSGQDGQRIAAPGRIWNAVKDEPEDLTGRHAGNNKSHPDDAQANTNDSDSDNDSDLCIDEQQRAGTLPRKRKGGISASVMNGVTPAELQKRPGLIPLTSNLAGPVQVMTAKDGAKLYSCPECNLFYADHLAFEIHLQAHGVSLGKRHICKECGTSFRRREHLDAHMTAHSQDRPFSCETCGRAFKRNEHLTRHRVLHSGDKQHVCADCGKSFFRKDHLMKHSQTHMLRKMTSGEG*

Sequence clustering based on sequence similarity using MMseqs2