Basic Information

Gene Symbol
ZFX
Assembly
GCA_003651465.1
Location
NW:8643-18507[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 1.3 86 3.2 0.1 3 23 16 36 15 36 0.94
2 15 0.94 64 3.7 3.8 1 23 968 991 968 991 0.81
3 15 0.00041 0.028 14.2 1.9 2 23 1079 1101 1078 1101 0.96
4 15 0.0083 0.56 10.1 0.1 2 23 1114 1135 1114 1135 0.98
5 15 1.4e-05 0.00093 18.9 2.3 2 23 1138 1159 1137 1159 0.97
6 15 0.0097 0.65 9.9 0.3 1 23 1165 1187 1165 1187 0.95
7 15 2.8e-05 0.0019 17.9 4.4 2 23 1194 1215 1193 1216 0.95
8 15 0.085 5.7 7.0 3.7 5 23 1229 1247 1228 1247 0.97
9 15 1.7e-05 0.0012 18.6 1.5 3 23 1254 1275 1253 1275 0.97
10 15 0.0079 0.53 10.2 0.3 2 23 1291 1311 1290 1311 0.97
11 15 5.2e-05 0.0035 17.1 0.7 1 20 1317 1336 1317 1339 0.92
12 15 6.5e-05 0.0044 16.8 2.7 1 23 1347 1369 1347 1369 0.99
13 15 0.0018 0.12 12.2 3.2 1 23 1375 1397 1375 1397 0.97
14 15 3.3e-06 0.00022 20.8 3.9 1 23 1403 1425 1403 1425 0.99
15 15 0.0011 0.076 12.9 6.3 1 23 1431 1453 1431 1454 0.96

Sequence Information

Coding Sequence
ATGGAGCTCAACAGCGGTGCGGGACCGCCTGTCGGGGCAGTCGCCTGTCCCGTTTGTACCTTGTACCTGCGCGAGGGTATTAGTTTGCAGAAGCATCTGGATACCCATCCCAAGGAACAAGTTATAGATGCTCTCATCAAGGCTAGCGCCTCCTCGACTCAGTCGcaccagcagcagcagcaacaacaacaacaacaacagcagcaagCTACCCCGGCGACATCAGTACCTGTATCGCTGCAACCGCAAGCTTCACAGCAAACCCCTACCTCTGTTCAGACGCCTCAAGCGTCACCCCAAGTCTCACAGAATTCCGCGCACATTTCCTCCTCTCATTCGCCGTATCCCATAGGACCCATCTTCGAATGTCCGCCTATAAGTACCATGATGCCGCCACAGTTCACCTCGTTCAGCTATCAACAATTTGTCAACAATGGGACCATGATGATACCGCAGTATGCGATGGCACCGCAGGCCAATCAGATGATGCAGATGCTGTACAATCCGTACGGTATGTACCAACAGCAACAAATACCCACCGTCCAAATGATCTCACCGGTTGCAGCTATCCCGGGCGCCGCGAGGATTCGACCAGTGGTCACCATGGCCGGGGAGAACAATGTCAGAACCGCCCTGGCAATTCCTGTAAATAGTCCCGAGCCCAAGCAGATCCTGCCTGAGATTTTGCCCGATACCGAGCCTGAATCCGGGCAAGTTATGCCGGATGTGAACCTTCCAGCCTCGCCTGTACTGCAGAACGAGGACGCGTCCGTCAGACAGGAGGAGAGCGACAACAATGCGTTGCCAATCGATCACAGAGGACAGCCGATGCAGAGTACCGCATCGCCTGGTGAAGGTACAGTTCAGCACGGGTATAACGCTATTCCTAGATCCATCACAATCGCTTGCGCCATAAATACCAATGACGATAAAGTGGAGAGTGTACTGCCGGACATGGAGGACGAGGAGCCATCGAATAACATTTCCACCGTGGACTTGCAGTGTAAATCTGTAACATACGAACAATCTGAAACACAACAGTTTACGCAACAGGTTATGCAAGAAGGGTACGTGAGTATATCCAATAGGAAAACTAACGCAACGAATGATGTTGACTCTATGACATGTGAACGCGAATCGGAAATGATGAGCGACGAAAGACCGGCAAGCCGCAACAGCAGTGTCAGTGTCAGCAATAACGTTCCATCGCCGCGGAATTCAATAACGATTCCAGACGCATTGAAAGACTCTATTCAACCTGAACTTAATTCGGTGGAAAAGCTAGAGAATTTGATAAGCATAATGGAAACGGAGCTTAATAGCGCTTCGCTTCAAACAGAAAATAGTTCATCAAATGATCGGGATAGATTAATAGatacgagagagaaatctGATAGGGAGGAGACCGTGATTCACGATACCGTAGTGACAATTCTAGGCCCTCACGACAAGGATCACATATTGCCTGATATAGAAGAAGCTAACAATACATGGTGCCCGAACGATTATGTAGATAACGAACTGAGAACGCTAGAAAAAACTTGTCGGTATTTGTCATACAATACAGAGTGCCCGAAAATAGATGACGGTTTGAAAAtgttagagaaaaatttgtataagtaTAAGTATAGTTTTTCAGCACCCCCGTCTCCTGTCACGAGGAAGAAGTGCCGCAAGACCGTGGCGCGTCGTTACAGCGCGCGATCGGAGCTCGGATCATGCGAAAATCTCAGCCCGTATCATCATCGTGGTGGCTTTGACGACGCGGCGGCCATGCAGGACGAGGACGaagacgaggacgacgacgacgatgtgGATATCGACGAGGACGAGAAGATCGATGAGGAGGATAATTTCGACGAGGCGGACATGGAGATCGAGGAGATTCCCAGTCCGCATACGCCTTTCGCGGAATGCGGCTTCAGATCGCACACACCATTGTCCACGATTAGCGGTATTTCCGTGTTAAGAGTTAGGAAAGATCTCAGCAAACCATGTTCACCCACATCCATACATTCGTTTCATCATGTGGACAGTGATAGCATAAGCCACGACGAGGACAGTAATGctgtagataataatattgtagatAATATTGCAGAGAAAGATCCGATTGACTGTTCTCAAATCGAAGAGAAGATTAAGACTGATCATCAGCATCAGGAGGCGCGCGCGACAGTGtgcgaaaataatgaaaaagttcAGGAATCGAGTAGTAGTAATAGTTATACATACCAGCAGTCAGTGATAACTGAACACGTTAGTTCATTCCCTGTGATGCACTCGCAGCCACCCGTCTTGATGCAAGAGTCATATTCCGCGACGAGTAAGACGCAAAATCTCTTAAACTTGTCGGAATCGATTAATCCTACAACCAGCACTGAATCCAAGAGCTTTCATTCTACCAAATCTACGTTGATGCCGAAGCAATCGATGGAATTGCTCAACATAAATGAGGATGCTCATGCCGGACCGATAAACGTCTTTGAATTTGAAGGACTACAAATATTAGTTCCTAGTACATTTATAAGCGATTCGTCTCAGAAAGCGGTTAGTGCGACCAGTCAGCAGTCCATGGCAAGTAGCGAGGGTGCAATAGGTATCGATGAGGAAGTCAAGAGTATTAATATGCGTGCCGATGAGACCATGCCGCCTAGAGGTGAACTGTCCGAACAAGAGAGCAATGGATGCACAGAGCCGTCTGCATGGCAGcTGTACATGGGTCAAGAATCTTCGCGCATGTCCACCTCTTACGATCTGTTGGCACGAGAAAGCTGGGAGGAATCAGAAGGATCTGACAACGAGATTAGTGGCCCGTTGTTGGATAGTAGATCGTTGGCCACGCACTTCACTTCGAGTCTGTTTCTGGATCGAGATCGGGAGACACCGACCAAACGGACGTTCAAGTGTTCTCACTGTAACGAGGTATTCGATTGTCCAAAAGAGCGCAGAGTTCATAGTACAACAGTACATAAGGAGGCAGTGCCCAGTAGCAGCAGAGATCAATTGGATCAGCCGGAGATGAAGGACATCAAGTTGCTGGACAATCGTGTGAATGTGTTCGACGATATATTTGTGCCGGGTCTGCACATGCAACAGATGTACCATCATCAACAGCCGCTCCTGCATCAGCTACAGCCACCACCGTCGCAGCCTGGAGCGGATGGTTTGACCAAGGCTGAAGGCGATCAAAAGATTGGCGAGAATCTGGTGATACCATCGAGCATCGAGGTGACCTGCGCGATATGCAGCCAACGATTTAGCAGTGAAAAATCTCTACAGATACATCATCGGCGTATGCATTTAGCTGAGGTAAACAAACGCATACGCGAGAACGCCAAGTGCCAGATATGCAACGAGGAGTTCCCGTCAGTGTTATTGTTCAACGCTCACCTGAAGATACACCCGTTGGAATGCGGACAGTGCGGTAAGTATTTTTACCGGAAGCAAAATTTCAAGCTGCATATGAAACGGCACTTGGGCATCAAACCGTTTCCGTGCACTGTGTGCGACAAGGCGTTCCTCACCAAGCAAAAACTGGACGAACATACCAACGGCCACACTGGCAACGCGCCCGTCAAATGTAGCTTGTGCAACGAGACTTTCCGCAGGTATTCGAATTTGACCCAGCACAAAAACCGGCATCACCTCAACATCAAGAAAAAACTCAAAGACTATATATGCCACTGCGGCGAAGTGTTTCACACGAAGAAGAAGCTCGCCTGGCACAAAGAGACGCACGACGAGAAACCCAAAGCATGCACGTATTGCAATGAGCGATTCATTCACATGGCCAGTCTGACGCGTCATATGCGTCGTGCCCACAATCGCCGATTCGTTCCTGATGCGCAGCGCGAAAGCGAGAACGTCGAGTGTCCTATTTGCAAGTGTATCTATTTACGATCGTCGTTGGCGGTGCACATGCGCGTGCACAACGGCGAACGGCCGTACGAGTGTCAGGTATGCTCCAAGGCGTTCAGCACCAAGTGGAATCTACAGTTGCACAAGTGGACGCATGCGGCACGCAGCACCAAGCCGTTCAAGTGTAATCAGTGCAGCGCGGCCTTTTATCGTCACAGCGACTACACGGCGCACATGAATTCCCACCGTAACGTGCGTCCGTACACGTGCAACTATTGCGGCGCGCAGTTCATCCGCAAGTACAACTGTCTGCGACATGTCAAGGAGCACGAGGAAAACAAGGCGTACACGTGCGACGTATGCAACAAGACCTTCCATCGCTCCTACTATCTCAAGGAGCATCTGCGGGTGCACTCGGGCGCGCGACCGTACACGTGTCACATATGCGGCAAGTCCAGCGGCACCAAGTCCAATCACAACAAGCACGTGCGAATCCATCACGCGCGCGAGCCTGTAAATaccgaaaattaa
Protein Sequence
MELNSGAGPPVGAVACPVCTLYLREGISLQKHLDTHPKEQVIDALIKASASSTQSHQQQQQQQQQQQQQATPATSVPVSLQPQASQQTPTSVQTPQASPQVSQNSAHISSSHSPYPIGPIFECPPISTMMPPQFTSFSYQQFVNNGTMMIPQYAMAPQANQMMQMLYNPYGMYQQQQIPTVQMISPVAAIPGAARIRPVVTMAGENNVRTALAIPVNSPEPKQILPEILPDTEPESGQVMPDVNLPASPVLQNEDASVRQEESDNNALPIDHRGQPMQSTASPGEGTVQHGYNAIPRSITIACAINTNDDKVESVLPDMEDEEPSNNISTVDLQCKSVTYEQSETQQFTQQVMQEGYVSISNRKTNATNDVDSMTCERESEMMSDERPASRNSSVSVSNNVPSPRNSITIPDALKDSIQPELNSVEKLENLISIMETELNSASLQTENSSSNDRDRLIDTREKSDREETVIHDTVVTILGPHDKDHILPDIEEANNTWCPNDYVDNELRTLEKTCRYLSYNTECPKIDDGLKMLEKNLYKYKYSFSAPPSPVTRKKCRKTVARRYSARSELGSCENLSPYHHRGGFDDAAAMQDEDEDEDDDDDVDIDEDEKIDEEDNFDEADMEIEEIPSPHTPFAECGFRSHTPLSTISGISVLRVRKDLSKPCSPTSIHSFHHVDSDSISHDEDSNAVDNNIVDNIAEKDPIDCSQIEEKIKTDHQHQEARATVCENNEKVQESSSSNSYTYQQSVITEHVSSFPVMHSQPPVLMQESYSATSKTQNLLNLSESINPTTSTESKSFHSTKSTLMPKQSMELLNINEDAHAGPINVFEFEGLQILVPSTFISDSSQKAVSATSQQSMASSEGAIGIDEEVKSINMRADETMPPRGELSEQESNGCTEPSAWQLYMGQESSRMSTSYDLLARESWEESEGSDNEISGPLLDSRSLATHFTSSLFLDRDRETPTKRTFKCSHCNEVFDCPKERRVHSTTVHKEAVPSSSRDQLDQPEMKDIKLLDNRVNVFDDIFVPGLHMQQMYHHQQPLLHQLQPPPSQPGADGLTKAEGDQKIGENLVIPSSIEVTCAICSQRFSSEKSLQIHHRRMHLAEVNKRIRENAKCQICNEEFPSVLLFNAHLKIHPLECGQCGKYFYRKQNFKLHMKRHLGIKPFPCTVCDKAFLTKQKLDEHTNGHTGNAPVKCSLCNETFRRYSNLTQHKNRHHLNIKKKLKDYICHCGEVFHTKKKLAWHKETHDEKPKACTYCNERFIHMASLTRHMRRAHNRRFVPDAQRESENVECPICKCIYLRSSLAVHMRVHNGERPYECQVCSKAFSTKWNLQLHKWTHAARSTKPFKCNQCSAAFYRHSDYTAHMNSHRNVRPYTCNYCGAQFIRKYNCLRHVKEHEENKAYTCDVCNKTFHRSYYLKEHLRVHSGARPYTCHICGKSSGTKSNHNKHVRIHHAREPVNTEN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01255007;
90% Identity
iTF_00280132;
80% Identity
-