Basic Information

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.036 2.9e+02 2.7 0.0 37 54 19 36 7 56 0.58

2 5 0.0016 13 7.0 0.0 33 33 135 135 49 178 0.70

3 5 0.0057 46 5.2 0.0 36 54 178 196 168 259 0.60

4 5 0.032 2.6e+02 2.8 0.0 31 53 253 275 243 277 0.83

5 5 0.044 3.6e+02 2.4 0.0 31 48 273 290 266 320 0.85

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.036	2.9e+02	2.7	37	54	19	36	7	56	0.58
2	5	0.0016	13	7.0	33	33	135	135	49	178	0.70
3	5	0.0057	46	5.2	36	54	178	196	168	259	0.60
4	5	0.032	2.6e+02	2.8	31	53	253	275	243	277	0.83
5	5	0.044	3.6e+02	2.4	31	48	273	290	266	320	0.85

Coding Sequence: ATGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCCTTCATTAGCACGCAACATGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACGTGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCCTTCATTAGCACGCAACGTGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACGTGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACGTGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACATGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACATGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACATGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACATGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACGTGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCCTTCATTAGCACGCAACGTGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACGTGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACGTGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCGTTCATTAGCACGCAACATGCTGTTACAATGCTATGTCGTCCAACATGTCGCCACTTCGCCTTCATTAGCACGCAACATGCTGTTACAACACTGCTGCCACACTGACGTCACGCAAAATCCTGCATCACGCAATCAGAGTTTACCGCGCGACTAG
Protein Sequence: MLLQCYVVQHVATSPSLARNMLLQCYVVQHVATSRSLARNVLLQCYVVQHVATSPSLARNVLLQCYVVQHVATSRSLARNVLLQCYVVQHVATSRSLARNVLLQCYVVQHVATSRSLARNMLLQCYVVQHVATSRSLARNMLLQCYVVQHVATSRSLARNMLLQCYVVQHVATSRSLARNMLLQCYVVQHVATSRSLARNVLLQCYVVQHVATSPSLARNVLLQCYVVQHVATSRSLARNVLLQCYVVQHVATSRSLARNVLLQCYVVQHVATSRSLARNMLLQCYVVQHVATSPSLARNMLLQHCCHTDVTQNPASRNQSLPRD

Sequence clustering based on sequence similarity using MMseqs2