Basic Information

Gene Symbol
-
Assembly
GCA_947568875.1
Location
OX387646.1:465103-466062[+]

Transcription Factor Domain

TF Family
HSF
Domain
HSF_DNA-bind domain
PFAM
PF00447
TF Group
Helix-turn-helix
Description
Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.05 4.1e+02 2.4 0.0 11 34 3 26 1 33 0.80
2 10 0.01 84 4.6 0.1 8 34 20 46 17 49 0.87
3 10 0.0087 71 4.8 0.1 8 34 40 66 37 71 0.86
4 10 0.016 1.3e+02 3.9 0.1 9 33 71 95 67 103 0.82
5 10 0.011 93 4.5 0.0 10 33 102 125 97 138 0.68
6 10 0.07 5.6e+02 1.9 0.1 8 32 140 164 130 171 0.64
7 10 0.01 81 4.7 0.0 9 33 171 195 165 201 0.86
8 10 0.018 1.4e+02 3.9 0.1 8 34 200 226 198 232 0.87
9 10 0.0055 45 5.5 0.2 13 34 225 246 219 272 0.54
10 10 0.006 49 5.3 0.5 11 36 263 288 257 318 0.56

Sequence Information

Coding Sequence
ATGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAGAATGATAGTTCTGTTGTCATGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAGAATGATAGTTCTGTTGTCATGCACGATGAGAATGGAAGTTCTGTTGTTGTGCACGATGAGAATGATAGTTCTGTTGTCATGCACGATGAGAATGATAGTTCTGTTGTTATGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAGAATGGTAGTTCTGTTGTCATGCACGATGAGAATGATAGTTCTGTTGTCATGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAAAATGGTAGTTCTGTTGTCGTGCACGATGAGAACGGTAGTTCTGTTGTCGTGCACGATGAGAATTATAGTTCTGTTGTCGTGCACGATGAGAATGATAGTGTTGTTGTCGTGCACGATGATAATGATAGTTCTGTTGTCATGCACGATGAGAATTATAGTTCTGTTGTCGTGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAGAATTATAGTTCTGTTGTCATGCACGATGATAATGATAGTTCTGTTGTCGTGCACGATGAGAATGATAGTTCTGTTGTCATGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAAAATGGTAGTTCTGTTGTCGTGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAGAATTATAGTTCTGTTGTCGTGCACAATGAGAATGATAGTTCTGTTGTTGTGCACGATAATAATGATAGTTCTGTTGTCATGTACGATGAGAATTATAGTTCTGTTGTCGTGCACGATGAGAATGGTAGTTCTGTTGTCGTGCACGATGAGAATGGTCATAAAATGTAA
Protein Sequence
MHDENGSSVVVHDENGSSVVVHDENDSSVVMHDENGSSVVVHDENDSSVVMHDENGSSVVVHDENDSSVVMHDENDSSVVMHDENGSSVVVHDENGSSVVMHDENDSSVVMHDENGSSVVVHDENGSSVVVHDENGSSVVVHDENYSSVVVHDENDSVVVVHDDNDSSVVMHDENYSSVVVHDENGSSVVVHDENGSSVVVHDENYSSVVMHDDNDSSVVVHDENDSSVVMHDENGSSVVVHDENGSSVVVHDENGSSVVVHDENYSSVVVHNENDSSVVVHDNNDSSVVMYDENYSSVVVHDENGSSVVVHDENGHKM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-