Basic Information

Gene Symbol
topi
Assembly
GCA_963576555.1
Location
OY754959.1:13013742-13016017[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 3.3e-05 0.0051 18.0 2.9 1 23 215 237 215 237 0.97
2 10 0.02 3.1 9.3 1.4 2 23 265 286 264 286 0.95
3 10 1.3 2e+02 3.6 0.1 2 19 341 358 340 360 0.92
4 10 0.0069 1 10.8 1.0 1 22 408 429 408 432 0.90
5 10 0.37 56 5.3 0.0 2 21 447 466 446 469 0.85
6 10 4.1e-07 6.2e-05 24.1 2.0 1 23 484 506 484 506 0.95
7 10 0.0059 0.89 11.0 0.7 3 23 514 537 513 537 0.92
8 10 0.36 55 5.3 1.6 1 23 543 565 543 565 0.88
9 10 5.2e-07 7.9e-05 23.7 0.2 3 23 573 593 571 593 0.98
10 10 0.0063 0.96 10.9 1.2 3 23 601 622 599 622 0.95

Sequence Information

Coding Sequence
ATGTATAGTGAAGATGAATATAACACCTCTGAAGCATGGCTGGCAGAGCAAATTTTTTCTCAGCTAAAAGATTTCAAGACCGAACCTCTAAGGGATAATGATGAAGATAGCAGATTAACTTTTGGTACAACTAAGGACTCATTGGATTATGATGAATCTACAGCAGTTATGTCAAGCAATGTTCTTGAGTTAATAGCACCCGGTGAGGACAATAACATACAAAACGATTCCCAACCAGATCCAGATCCAAAGAAAAATCAGAGTcaagatttttttcttctgcaaGAACAATCAAATGAAGAGTACAGGAATGCGAATAACCATGAAATCCAAGATATATTCCAATATTCcgAACCCTCCTTTAAGATTCCGCAAAGCATTGTGGAATGTTCCAACTGCAATTGCATCTTCCAAGCCGATTCCTTTCCCCAGCATATCTGTGACTATGGCGAAGATACAAAGCTGATTATTCCTGAACCGATGGACCCAATGTCAATTACATCTTATCAAGCGGGTCCAGTTGAACCGCCATGCATACGACTCTTAAGAGAAAATCAAATCCGTATTCGCCGCTTTCTTAAAGATGAACTTAAATACGACGTTAACGCTGGCACCACAactacaaaaaaacaagaaggtCCCCATGAGTGTACTTTGTGCGAACGAAAGTTTGTCCATGCATCGGGATTGTCGCGTCACATGGAGAAACACGCACTCGATCTTATACCGTCCACTTCTGCGCCCAGTATGAACAACGGATGTCCGCCAACCAATGGTTTAAAAGTGGTCATCAAATGTACTATTTGTGGGCGGATTTTCTACGAAGCAGAAACCAGCTTCAAACACCTTTGCATGCATTTCCCAAAAACTAACGAAGCTGAGCCAGAATTCGACGAGTTCGCAGATTTTCCCTACGAAAACTACCTTGACGATGGCTTAAACTTTTTAAAGACTGAGTCCAAAATGTCCAACAGCAAGCCTACTTCCTACTTCAAGATGGTAATTCTAAGTTGTGTCCTACAGTGCGAGTTCTGCGATCTGCTTTTCTCCGAGGTTTCCTTTCTATTGGCTCACTCGGCTTGCCACCAGCCGCAGTGGCCTTTTGAATGTTTTGCATGTGAAATTCATGTGTCCACCTCGAAGGACATTTTCATGCACTGGCAGGCGGAGTGTGCCTTTGCAAGAGAGAGCTTAAAGCTTGGTTGCACGTCGCAAAGGTACTACGTATGCAATGTTTGTGAGAATAAGTTTGTGTCATTGGAACAACTGCATGAGCATAGGTACACGGCTTATCATTTTTTCCCGCGGCTGGATTCAAGCAAAGGAAGACTGCTGTTGCCGTGCGAATACTGTGGGGGAATATTTGAAACCGCAAATGATATTGTCGCTCACTTCGATGAGCGACACtacaaaaagaacaaacaacATGTCGGCACTAAGTCTCGCCAGTACTTGTGCGACATTTGTGGCAAGACGTACACACAATCAAGTCATTTATGGCAGCATTTACGGTTCCATAAAGGTGTCAAACCATTTGGCTGCAATGAACCAGGCTGCTCACGTCGATTCACCATTCGTCCGGATCTGAATGACCACATTCGCAAGTGTCACACAGGCGAGCGGCCATACCATTGCCTCATATGTGGCAGGCGCTTCCTAACTGGTTCGGTGTTCTACCAACATCGTCTAATTCATCGTGGAGAACGGCGTTACGGATGCGACGAGTGCGGCAAGAGATTCTATCGTGCCGATGCATTGAAAAACCATCTACGCATTCACACGGGTGAGAAACCCTATGGCTGCCTCTTCTGCACAAAGAGTTTCCGCCAGCGAGGAGACCGCGATAAACACATCCGAGCACGACACTCCAGTTTGGATGCAAAGTCTCGTCTAATGATGCAAATGCGCAAGTTGCAACTAGAGGCGGCCGCCAAAGCCAGCGCCAACCCCTCGTCATCGACACCAGCCGAGGAGGTGCTGATGTTTGGAAACATGGCTTTTCCGAAAAGCATGTTCCAACCGCTGTTGCCAGACATCGATGCTGGTCAAGACTGA
Protein Sequence
MYSEDEYNTSEAWLAEQIFSQLKDFKTEPLRDNDEDSRLTFGTTKDSLDYDESTAVMSSNVLELIAPGEDNNIQNDSQPDPDPKKNQSQDFFLLQEQSNEEYRNANNHEIQDIFQYSEPSFKIPQSIVECSNCNCIFQADSFPQHICDYGEDTKLIIPEPMDPMSITSYQAGPVEPPCIRLLRENQIRIRRFLKDELKYDVNAGTTTTKKQEGPHECTLCERKFVHASGLSRHMEKHALDLIPSTSAPSMNNGCPPTNGLKVVIKCTICGRIFYEAETSFKHLCMHFPKTNEAEPEFDEFADFPYENYLDDGLNFLKTESKMSNSKPTSYFKMVILSCVLQCEFCDLLFSEVSFLLAHSACHQPQWPFECFACEIHVSTSKDIFMHWQAECAFARESLKLGCTSQRYYVCNVCENKFVSLEQLHEHRYTAYHFFPRLDSSKGRLLLPCEYCGGIFETANDIVAHFDERHYKKNKQHVGTKSRQYLCDICGKTYTQSSHLWQHLRFHKGVKPFGCNEPGCSRRFTIRPDLNDHIRKCHTGERPYHCLICGRRFLTGSVFYQHRLIHRGERRYGCDECGKRFYRADALKNHLRIHTGEKPYGCLFCTKSFRQRGDRDKHIRARHSSLDAKSRLMMQMRKLQLEAAAKASANPSSSTPAEEVLMFGNMAFPKSMFQPLLPDIDAGQD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01254356;
90% Identity
-
80% Identity
-