Basic Information

Insect: Ferdinandea cuprea
Gene Symbol: lz
Assembly: GCA_963576555.1
Location: OY754958.1:128207921-128248701[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.6e-73 2.8e-69 231.5 0.0 3 129 74 200 72 200 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.6e-73	2.8e-69	231.5	0.0	3	129	74	200	72	200	0.98

Sequence Information

Coding Sequence: ATGCATCTGCCAAGCGGTACAACGACGGCAGTCTACACTGGCTCCACCGCCGGACCTGTTACTTCGACGTCGTCCGTCGCATCGGCGGCAGATTGGGGTCTGTCCAGTGGCGGTGGCATATACCAAAAGGGCAGCATGATCGATGTGCCCAGCAACAATAGTGGCAGTAGTTCGCCGCCAACGTCACAGGATCTATGGTGGACGGAGCGGTTAATTTTGGACGCACAACAGGAATACCCAGGAGAATTAGTTCGAACCGGTAATCCATACTTTCTCTGCTCAGCGCTCCCCACGCATTGGCGATCGAATAAAACTCTGCCGCTGGCGTTTAAAGTTGTCGCTCTAGTCGATGTCGGTGACGGCACAATAGTAACCATTCGTGCTGGAAACGATGAGAACTACTGCGCCGAGCTGCGAAACTGCACAGCGGTGATGAAGAATCAAGTTGCCAAATTTAATGACCTGCGTTTTGTTGGACGTAGCGGGCGAGgGAAGAGCTTTACGCTGACTATAACCGTGTCAACGAGCCCGCCACAGGTAGCCACATATGCAAAAGCAATCAAAGTTACGGTTGACGGACCACGGGAGCCACGATCAAAAACAAgtCCAACCGGTGGTCATCAATTTCGCGCCTTGGGTCTGGGTCAACGACCATACCTCGATACTCCATTCTCCAGCCATTTTCGTGAATTAGAGACATTAAGACGTAAGGCTCCTACTGGCTCATCGCAAGCACCATTAGGCAGCAATCACTCATCCTCCAATAGTACAATAAATTCCGACTGTCAGGGCTATAAGCCCAATGCACCACAGATACAAGAAAACAATTTGATGGGAGCTGCCGAATGGACGGGCTACACGCCGAGCACAACAACGCCAGGTGTCAGCTCATACCACTCGTATCAGCCATTGCAGACGAATGCATCAAGTGCAGCGGCAGCggcggcggcagcagcagcagcttaTGGCTACGATAGTCACACAGCGGGTAATCCTCCACCCGGTCCACCACCGCCTCCACCCCCACCGGATCATCATACGAATTTCCATCTGCCCACTGTGCTGACAGACATGCAACCCTTCTGCGCCCCCTCCGACTATCATCAGACAGGAATAGCACCAACTGCAGCGTCAGGCGGAATATTACCCCACACACAACCGCCCATCTGTAGTCCGACTTACGGCTCGACAAAGTCTGAGATTGACTCCCTCAACGCATCGTATCCATCGTACAACAACTGGTCGAATGGCTATAATAACTTTCAGTATGGTAACTGTGCGGCCCAGGCTCAATATCCAGGAcacactgcacccacaatggttcTCTATCCGCAGCTGTATTCGACTGTGAATCAAAATCAGATTCATTTACACCTCCACGGCACCGACAAGCTGGAGCAGTATTTGGGTCCCGAGAATTCTCTGACTATCAGTTCCATAGGCGGCGGCAGTCGTTCCGGCATCGAAATCGGTATCGGAACTTCAGACCATGAATCGGCTATGATGGCCAATGAGGCTGGCGAACAACAGCAACACTCGCACAATGTACAGCAGGAGAATGAAGTGCCTCAGGATCATCGAACCGATGAAGATGTTGTGGATCCGGGAAGCGTTTGGCGACCCTACTGA
Protein Sequence: MHLPSGTTTAVYTGSTAGPVTSTSSVASAADWGLSSGGGIYQKGSMIDVPSNNSGSSSPPTSQDLWWTERLILDAQQEYPGELVRTGNPYFLCSALPTHWRSNKTLPLAFKVVALVDVGDGTIVTIRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTSPPQVATYAKAIKVTVDGPREPRSKTSPTGGHQFRALGLGQRPYLDTPFSSHFRELETLRRKAPTGSSQAPLGSNHSSSNSTINSDCQGYKPNAPQIQENNLMGAAEWTGYTPSTTTPGVSSYHSYQPLQTNASSAAAAAAAAAAAYGYDSHTAGNPPPGPPPPPPPPDHHTNFHLPTVLTDMQPFCAPSDYHQTGIAPTAASGGILPHTQPPICSPTYGSTKSEIDSLNASYPSYNNWSNGYNNFQYGNCAAQAQYPGHTAPTMVLYPQLYSTVNQNQIHLHLHGTDKLEQYLGPENSLTISSIGGGSRSGIEIGIGTSDHESAMMANEAGEQQQHSHNVQQENEVPQDHRTDEDVVDPGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01116223;
90% Identity: iTF_00314921; iTF_00313220; iTF_00312362; iTF_01300587; iTF_00389393; iTF_01299795; iTF_01541204; iTF_00311577; iTF_00310782; iTF_00315712; iTF_00314040;
80% Identity: -