Basic Information

Gene Symbol
-
Assembly
GCA_951449985.1
Location
OX602139.1:2159819-2177415[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 2.2 1.6e+02 3.4 0.2 1 23 267 290 267 290 0.89
2 9 0.015 1 10.3 1.9 1 23 387 410 387 410 0.95
3 9 9.6e-06 0.00068 20.3 1.0 2 23 415 436 414 436 0.97
4 9 0.0092 0.65 10.9 5.2 2 23 444 464 444 464 0.98
5 9 0.0012 0.087 13.7 1.6 1 21 470 490 470 495 0.94
6 9 0.0013 0.088 13.7 0.2 1 23 503 526 503 526 0.94
7 9 0.0004 0.029 15.2 0.1 1 23 532 555 532 555 0.97
8 9 7.1e-06 0.0005 20.7 1.2 1 23 565 587 565 587 0.94
9 9 0.00012 0.0084 16.9 3.0 2 23 594 616 593 616 0.96

Sequence Information

Coding Sequence
atGGAGCAAGATGTGGAAAATGGATTCAGATCTGTGTGCTGTACTTGCCTTAGCAATGATCGCGActtgttttcaataaataacattagtcaaatatatcaaatattccGACTAATAATGTACGATTTCGCGGGCGACAGGTTTGGTGAGACGCAGCCGGAGATTGAGCAGTTGGTGTGTTGGGAGTGCATGGCACTGATGAAGAGGTTTGTCAAGTTCAAATGGCAGGTGCACAGCGCTCAGGAGCATCTGAGAGTCCTCGCCTTGAGTCACACGCAAGAgACTCTGGAGCACTCCTACATGTCCCAGTCATTGTCATCTTTAGAAGTACACACGAAGACCGATTACGACAAAATATACTTTGAGTTCCCCACAGTGCCTGAGCCAAGGCAGTACATAGCCATCACATCCGGCTACAGTGTCAAGAACGAACAGCTGGACGTAGCTCAAGTTGTGAAGgataatatgaatattgatattgatGAGCATCTCTTGGAAGTGCCCGAGATAGTACTGGAGAATCCGGTCACCGGTGTGATGTCCCACATTGTAGTGGACACAGATGCCTTAGTTACCCCAGCTGACCCCTTCTCAACCGTTAAAGGAGAGTTACCCGAGCTGACTGTTGGGCCACTGACCGGAGAGAAGATCGAGTCTGTTATAATGGCGTGTGCGAAGGACACTAACCATGAGAAACGAGAAGCAAAGCTTGGCTATGTCACTGAATACATGACAGAAGCTGACATGCTGGCTAGCAGAGAAGAAGCCAAGAAGAAAGTCCACTACGCCACTTCGGTGTACAAGTGCGAGCTGTGCATTATCGGGTTCTACACACAGCAGGAGGTTGAAGACCACTTCGTGAAGGCGCATCGAGCTcGTCCCGGCGTGGTTCCCTGTCGCGTGTGCTACGTGTACGTGGAGGAGGGCCGGCTGGGCGCGCACGTGGACGGCCACTACACGCGCCACGCCTGCCGCCGGTGCCGACACCGGGACACCAGCGCCGCGCTCATGCTGCGCCACGTGCGCGCGCACCACTCCGCCAACGACGGCATCAACATCGCCCCGCACAAGAACcgaaagaaaaagaaagattCCAGCGAGGTGCCAACAAAACCTGCCGATCTGAGAAAACTGCTCTCCAAAACTACCATAGTCGGCTACAAGTGCCTCGAGTGTGATATGTTCTTTAAGACAACTCGCGCGCGCAAGAACCACGTGGCGAGATTCCACCGCGAGGGATTGCAGTGCGATGTGTGCAAGAAGAGATTCGTTAACAAGACCACCCTGGCCACCCATCTTAGGTTGCACGAGGGTCCCTTGCCCCGGGAGCGTTGCCACATCTGCCACAAGATGGTCCGCAGCGTGCAGCTGAAGTACCACATCCGTCGCCACGAGAGCACCAGCCGTTACGAGTGTCGCGACTGCAACAAGCTGTTCTCCCACCTGGCTACCTACCAGGCGCACCTCAAGTACTCGAGAGCACACGCCACCGATCACGTCCTCAAgTTCCCATGTCCGATGTGCAACAAGGGGTACCCCAGTAAGGAGGCGATGCAAGACCACTTCAACTATCAACATCTTGGCAAGACGGCGCACAAGTGTCCCATCTGTGAAAAGCCGATAGCGTCCCGCGCCAACGTGGACCGTCATATGATGAGGGTCCACGGGGAGAAGAAGGAGAAACCCAGGAACCACGTGTGCCATCTGTGCGGGAAGGCGTTCACAGACAAGAAGGCGCTCACCCAACACGCGGTCATCCACTCCGGTGCGCGGCCTCTCTCCTGCGACGTTTGCCATCAGACCTTCAAGCAGAAAGCTTCTCTGTACACCCATCGCAAGCGCGTCCACAAGTTGATACCGACCAAGCGaatagttacatacatacatgatgAAAAATCTGACCAATAG
Protein Sequence
MEQDVENGFRSVCCTCLSNDRDLFSINNISQIYQIFRLIMYDFAGDRFGETQPEIEQLVCWECMALMKRFVKFKWQVHSAQEHLRVLALSHTQETLEHSYMSQSLSSLEVHTKTDYDKIYFEFPTVPEPRQYIAITSGYSVKNEQLDVAQVVKDNMNIDIDEHLLEVPEIVLENPVTGVMSHIVVDTDALVTPADPFSTVKGELPELTVGPLTGEKIESVIMACAKDTNHEKREAKLGYVTEYMTEADMLASREEAKKKVHYATSVYKCELCIIGFYTQQEVEDHFVKAHRARPGVVPCRVCYVYVEEGRLGAHVDGHYTRHACRRCRHRDTSAALMLRHVRAHHSANDGINIAPHKNRKKKKDSSEVPTKPADLRKLLSKTTIVGYKCLECDMFFKTTRARKNHVARFHREGLQCDVCKKRFVNKTTLATHLRLHEGPLPRERCHICHKMVRSVQLKYHIRRHESTSRYECRDCNKLFSHLATYQAHLKYSRAHATDHVLKFPCPMCNKGYPSKEAMQDHFNYQHLGKTAHKCPICEKPIASRANVDRHMMRVHGEKKEKPRNHVCHLCGKAFTDKKALTQHAVIHSGARPLSCDVCHQTFKQKASLYTHRKRVHKLIPTKRIVTYIHDEKSDQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-